cn.mops

DOI: 10.18129/B9.bioc.cn.mops    

cn.mops - Mixture of Poissons for CNV detection in NGS data

Bioconductor version: Release (3.6)

cn.mops (Copy Number estimation by a Mixture Of PoissonS) is a data processing pipeline for copy number variations and aberrations (CNVs and CNAs) from next generation sequencing (NGS) data. The package supplies functions to convert BAM files into read count matrices or genomic ranges objects, which are the input objects for cn.mops. cn.mops models the depths of coverage across samples at each genomic position. Therefore, it does not suffer from read count biases along chromosomes. Using a Bayesian approach, cn.mops decomposes read variations across samples into integer copy numbers and noise by its mixture components and Poisson distributions, respectively. cn.mops guarantees a low FDR because wrong detections are indicated by high noise and filtered out. cn.mops is very fast and written in C++.

Author: Guenter Klambauer

Maintainer: Guenter Klambauer <cn.mops at bioinf.jku.at>

Installation

To install this package, start R and enter:

## try http:// if https:// URLs are not supported
source("https://bioconductor.org/biocLite.R")
biocLite("cn.mops")

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("cn.mops")

 

PDF	R Script	cn.mops: Manual for the R package
PDF		Reference Manual

Details

biocViews	CellBiology, CopyNumberVariation, Genetics, HapMap, Homo_sapiens, Sequencing, Software
Version	1.24.0
In Bioconductor since	BioC 2.9 (R-2.14) (6.5 years)
License	LGPL (>= 2.0)
Depends	R (>= 2.12), methods, utils, stats, graphics, parallel, GenomicRanges
Imports	BiocGenerics, Biobase, IRanges, Rsamtools, GenomeInfoDb, S4Vectors, exomeCopy
LinkingTo
Suggests	DNAcopy
SystemRequirements
Enhances
URL	http://www.bioinf.jku.at/software/cnmops/cnmops.html
Depends On Me	panelcn.mops
Imports Me
Suggests Me
Build Report

Package Archives

Follow Installation instructions to use this package in your R session.

Source Package	cn.mops_1.24.0.tar.gz
Windows Binary	cn.mops_1.24.0.zip (32- & 64-bit)
Mac OS X 10.11 (El Capitan)	cn.mops_1.24.0.tgz
Source Repository	git clone https://git.bioconductor.org/packages/cn.mops
Package Short Url	http://bioconductor.org/packages/cn.mops/
Package Downloads Report	Download Stats