Testing groups of covariates/features for association with a response variable, with applications to gene set testing

Bioconductor version: 2.9

The global test tests groups of covariates (or features) for association with a response variable. This package implements the test with diagnostic plots and multiple testing utilities, along with several functions to facilitate the use of this test for gene set testing of GO and KEGG terms.

Author: Jelle Goeman and Jan Oosting, with contributions by Livio Finos and Aldo Solari

Maintainer: Jelle Goeman <j.j.goeman at>

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PDF R Script Global Test
PDF R Script Global Test (deprecated version 4)
PDF   Reference Manual


biocViews Microarray, OneChannel, Bioinformatics, DifferentialExpression, GO, Pathways
Depends methods
Imports Biobase(>= 2.5.5), survival, AnnotationDbi, annotate, multtest, graphics
Suggests vsn, golubEsets, KEGG.db, hu6800.db, Rgraphviz, GO.db, lungExpression,, annotate, Biobase(>= 2.5.5), survival, GSEABase, penalized, gss, MASS, boot, rpart
System Requirements
License GPL (>= 2)
Depends On Me GlobalAncova
Imports Me SIM
Suggests Me topGO
Version 5.8.1
Since Bioconductor 1.6 (R-2.1) or earlier

Package Downloads

Package Source globaltest_5.8.1.tar.gz
Windows Binary (32- & 64-bit)
MacOS 10.5 (Leopard) binary globaltest_5.8.1.tgz
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