DOI: 10.18129/B9.bioc.PGPC    

This package is for version 3.8 of Bioconductor; for the stable, up-to-date release version, see PGPC.

Experimental data and analysis of the chemical-genetic interaction screen in isogenic HCT116 cell lines

Bioconductor version: 3.8

This package contains the experimental data and a vignette guiding through the analysis of a chemical-genenetic interaction screen in isogenic HCT116 cell lines. The code can be executed to generate all results and figures for the manuscript "A chemical-genetic interaction map of small molecules using high-throughput imaging in cancer cells" accepted for publicaton at Molecular Systems Biology. Data availability: Complementary views on this dataset are available through different repositories. The image data files are available from the BioStudies database at the European Bioinformatics Institute (EMBL-EBI) under the accession S-BSMS-PGPC1 ( An interactive front-end for exploration of the images is provided by the IDR database The authors are hosting an interactive webpage to browse images and interaction profiles at

Author: Felix Klein

Maintainer: Felix Klein <daggoth at>

Citation (from within R, enter citation("PGPC")):


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biocViews CancerData, ColonCancerData, ExperimentData
Version 1.10.0
License Artistic-2.0
Depends R (>= 3.0), EBImage, imageHTS, SearchTrees, limma, RColorBrewer, gplots, splots, ggplot2, geneplotter, ChemmineR, reshape2, plyr
Suggests BiocStyle, knitr
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