DOI: 10.18129/B9.bioc.birta    

This package is for version 3.8 of Bioconductor; for the stable, up-to-date release version, see birta.

Bayesian Inference of Regulation of Transcriptional Activity

Bioconductor version: 3.8

Expression levels of mRNA molecules are regulated by different processes, comprising inhibition or activation by transcription factors and post-transcriptional degradation by microRNAs. birta (Bayesian Inference of Regulation of Transcriptional Activity) uses the regulatory networks of TFs and miRNAs together with mRNA and miRNA expression data to predict switches in regulatory activity between two conditions. A Bayesian network is used to model the regulatory structure and Markov-Chain-Monte-Carlo is applied to sample the activity states.

Author: Benedikt Zacher, Khalid Abnaof, Stephan Gade, Erfan Younesi, Achim Tresch, Holger Froehlich

Maintainer: Benedikt Zacher <zacher at>, Holger Froehlich <frohlich at>

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biocViews GeneExpression, GraphAndNetwork, Microarray, Sequencing, Software, Transcription
Version 1.26.0
In Bioconductor since BioC 2.10 (R-2.15) (7 years)
License GPL (>= 2)
Depends limma, MASS, R (>= 2.10), Biobase, methods
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