DOI: 10.18129/B9.bioc.BUScorrect    

This package is for version 3.8 of Bioconductor; for the stable, up-to-date release version, see BUScorrect.

Batch Effects Correction with Unknown Subtypes

Bioconductor version: 3.8

High-throughput experimental data are accumulating exponentially in public databases. However, mining valid scientific discoveries from these abundant resources is hampered by technical artifacts and inherent biological heterogeneity. The former are usually termed "batch effects," and the latter is often modelled by "subtypes." The R package BUScorrect fits a Bayesian hierarchical model, the Batch-effects-correction-with-Unknown-Subtypes model (BUS), to correct batch effects in the presence of unknown subtypes. BUS is capable of (a) correcting batch effects explicitly, (b) grouping samples that share similar characteristics into subtypes, (c) identifying features that distinguish subtypes, and (d) enjoying a linear-order computation complexity.

Author: Xiangyu Luo <xyluo1991 at gmail.com>, Yingying Wei <yweicuhk at gmail.com>

Maintainer: Xiangyu Luo <xyluo1991 at gmail.com>

Citation (from within R, enter citation("BUScorrect")):


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biocViews BatchEffect, Bayesian, Clustering, FeatureExtraction, GeneExpression, Software, StatisticalMethod
Version 1.0.0
In Bioconductor since BioC 3.8 (R-3.5) (0.5 years)
License GPL (>= 2)
Depends R (>= 3.5.0)
Imports gplots, methods, grDevices, stats, SummarizedExperiment
Suggests BiocStyle, knitr, RUnit, BiocGenerics
Depends On Me
Imports Me
Suggests Me
Links To Me
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Source Package BUScorrect_1.0.0.tar.gz
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Package Short Url http://bioconductor.org/packages/BUScorrect/
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