sscu

DOI: 10.18129/B9.bioc.sscu    

Strength of Selected Codon Usage

Bioconductor version: Release (3.6)

The package calculates the indexes for selective stength in codon usage in bacteria species. (1) The package can calculate the strength of selected codon usage bias (sscu, also named as s_index) based on Paul Sharp's method. The method take into account of background mutation rate, and focus only on four pairs of codons with universal translational advantages in all bacterial species. Thus the sscu index is comparable among different species. (2) The package can detect the strength of translational accuracy selection by Akashi's test. The test tabulating all codons into four categories with the feature as conserved/variable amino acids and optimal/non-optimal codons. (3) Optimal codon lists (selected codons) can be calculated by either op_highly function (by using the highly expressed genes compared with all genes to identify optimal codons), or op_corre_CodonW/op_corre_NCprime function (by correlative method developed by Hershberg & Petrov). Users will have a list of optimal codons for further analysis, such as input to the Akashi's test. (4) The detailed codon usage information, such as RSCU value, number of optimal codons in the highly/all gene set, as well as the genomic gc3 value, can be calculate by the optimal_codon_statistics and genomic_gc3 function. (5) Furthermore, we added one test function low_frequency_op in the package. The function try to find the low frequency optimal codons, among all the optimal codons identified by the op_highly function.

Author: Yu Sun

Maintainer: Yu Sun <sunyu1357 at gmail.com>

Installation

To install this package, start R and enter:

## try http:// if https:// URLs are not supported
source("https://bioconductor.org/biocLite.R")
biocLite("sscu")

Documentation

PDF		Reference Manual
Text		NEWS

Details

biocViews	GeneExpression, Genetics, Software, WholeGenome
Version	2.8.0
In Bioconductor since	BioC 3.3 (R-3.3) (2 years)
License	GPL (>= 2)
Depends	R (>= 3.3)
Imports	Biostrings(>= 2.36.4), seqinr (>= 3.1-3), BiocGenerics(>= 0.16.1)
LinkingTo
Suggests	knitr, rmarkdown
SystemRequirements
Enhances
URL
Depends On Me
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Build Report

Package Archives

Follow Installation instructions to use this package in your R session.

Source Package	sscu_2.8.0.tar.gz
Windows Binary	sscu_2.8.0.zip
Mac OS X 10.11 (El Capitan)	sscu_2.8.0.tgz
Source Repository	git clone https://git.bioconductor.org/packages/sscu
Package Short Url	http://bioconductor.org/packages/sscu/
Package Downloads Report	Download Stats