Harman

DOI: 10.18129/B9.bioc.Harman    

The removal of batch effects from datasets using a PCA and constrained optimisation based technique

Bioconductor version: Release (3.6)

Harman is a PCA and constrained optimisation based technique that maximises the removal of batch effects from datasets, with the constraint that the probability of overcorrection (i.e. removing genuine biological signal along with batch noise) is kept to a fraction which is set by the end-user.

Author: Josh Bowden [aut], Jason Ross [aut, cre], Yalchin Oytam [aut]

Maintainer: Jason Ross <jason.ross at csiro.au>

Installation

To install this package, start R and enter:

## try http:// if https:// URLs are not supported
source("https://bioconductor.org/biocLite.R")
biocLite("Harman")

Documentation

HTML	R Script	IntroductionToHarman
PDF		Reference Manual
Text		NEWS

Details

biocViews	BatchEffect, DNAMethylation, Microarray, MultipleComparison, Normalization, Preprocessing, PrincipalComponent, Software, StatisticalMethod, Transcription
Version	1.6.0
In Bioconductor since	BioC 3.3 (R-3.3) (2 years)
License	GPL-3 + file LICENCE
Depends	R (>= 3.3)
Imports	Rcpp (>= 0.11.2), graphics, stats
LinkingTo	Rcpp
Suggests	HarmanData, BiocGenerics, BiocStyle, knitr, rmarkdown, RUnit, RColorBrewer, bladderbatch, limma, minfi, lumi, msmsEDA, affydata, minfiData, sva
SystemRequirements
Enhances
URL	http://www.bioinformatics.csiro.au/harman/
BugReports	https://github.com/JasonR055/Harman/issues
Depends On Me
Imports Me
Suggests Me
Build Report

Package Archives

Follow Installation instructions to use this package in your R session.

Source Package	Harman_1.6.0.tar.gz
Windows Binary	Harman_1.6.0.zip (32- & 64-bit)
Mac OS X 10.11 (El Capitan)	Harman_1.6.0.tgz
Source Repository	git clone https://git.bioconductor.org/packages/Harman
Package Short Url	http://bioconductor.org/packages/Harman/
Package Downloads Report	Download Stats