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Roleswitch

DOI: 10.18129/B9.bioc.Roleswitch    

Infer miRNA-mRNA interactions using paired expression data from a single sample

Bioconductor version: Release (3.5)

Infer Probabilities of MiRNA-mRNA Interaction Signature (ProMISe) using paired expression data from a single sample. Roleswitch operates in two phases by inferring the probability of mRNA (miRNA) being the targets ("targets") of miRNA (mRNA), taking into account the expression of all of the mRNAs (miRNAs) due to their potential competition for the same miRNA (mRNA). Due to dynamic miRNA repression in the cell, Roleswitch assumes that the total transcribed mRNA levels are higher than the observed (equilibrium) mRNA levels and iteratively updates the total transcription of each mRNA targets based on the above inference. NB: in the paper, we used ProMISe as both the model name and inferred score name.

Author: Yue Li

Maintainer: Yue Li <yueli at cs.toronto.edu>

Citation (from within R, enter citation("Roleswitch")):

Installation

To install this package, start R and enter:

## try http:// if https:// URLs are not supported
source("https://bioconductor.org/biocLite.R")
biocLite("Roleswitch")

Documentation

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browseVignettes("Roleswitch")

 

PDF R Script Roleswitch
PDF   Reference Manual
Text   NEWS

Details

biocViews Software, miRNA
Version 1.14.0
In Bioconductor since BioC 2.13 (R-3.0) (4 years)
License GPL-2
Depends R (>= 2.10), pracma, reshape, plotrix, microRNA, biomaRt, Biostrings, Biobase, DBI
Imports
LinkingTo
Suggests ggplot2
SystemRequirements
Enhances
URL http://www.cs.utoronto.ca/~yueli/roleswitch.html
Depends On Me
Imports Me miRLAB
Suggests Me
Build Report  

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Source Package Roleswitch_1.14.0.tar.gz
Windows Binary Roleswitch_1.14.0.zip
Mac OS X 10.11 (El Capitan) Roleswitch_1.14.0.tgz
Source Repository git clone https://git.bioconductor.org/packages/Roleswitch
Package Short Url http://bioconductor.org/packages/Roleswitch/
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