Changes in version 1.8.0: o Improved computational performance and RTN workflows. Changes in version 1.6.0: o Improved computational performance for permutation analysis and other parallel processing pipelines. o Fix a phyper function issue. Changes in version 1.4.0: o Introduced 2-tailed GSEA and other related methods. Changes in version 1.2.0: o Introduced variant set enrichment analysis for regulons. Changes in version 1.0.0: o 1st Bioconductor release of RTN [2013-10-15].