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This package is for version 3.4 of Bioconductor; for the stable, up-to-date release version, see sscu.

Strength of Selected Codon Usage

Bioconductor version: 3.4

The package can calculate the indexes for selective stength in codon usage in bacteria species. (1) The package can calculate the strength of selected codon usage bias (sscu, also named as s_index) based on Paul Sharp's method. The method take into account of background mutation rate, and focus only on four pairs of codons with universal translational advantages in all bacterial species. Thus the sscu index is comparable among different species. (2) Translational accuracy selection can be inferred from Akashi's test. The test tabulating all codons into four categories with the feature as conserved/variable amino acids and optimal/non-optimal codons. (3) Optimal codon lists (selected codons) can be calculated by either op_highly function (by using the highly expressed genes compared with all genes to identify optimal codons biased used in the highly expressed genes), or op_corre_CodonW/op_corre_NCprime function (by correlative method developed by Hershberg & Petrov). Users will have a list of optimal codons for further analysis, such as input to the Akashi's test. (4) The detailed codon usage information, such as RSCU value, number of optimal codons in the highly/all gene set, as well as the genomic gc3 value, can be calculate by the optimal_codon_statistics and genomic_gc3 function. (5) Furthermore, we added one test function proportion_index in the package. The function focus on the proportion of optimal codon against its corresponding non-optimal codons for the the four and six codon boxes.

Author: Yu Sun

Maintainer: Yu Sun <sunyu1357 at>

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biocViews GeneExpression, Genetics, Software, WholeGenome
Version 2.2.0
In Bioconductor since BioC 3.3 (R-3.3) (1 year)
License GPL (>= 2)
Depends R (>= 3.3)
Imports Biostrings(>= 2.36.4), seqinr (>= 3.1-3), BiocGenerics(>= 0.16.1)
Suggests knitr, rmarkdown
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