TPP-package | Thermal proteome profiling (TPP) |
.onLoad | Thermal proteome profiling (TPP) |
analyze2DTPP | Analyze 2D-TPP experiment |
analyzeTPPCCR | Analyze TPP-CCR experiment |
analyzeTPPTR | Analyze TPP-TR experiment |
hdacCCR_config | The configuration table to analyze hdacCCR_data. |
hdacCCR_data | TPP-CCR example dataset (replicates 1 and 2) |
hdacCCR_smallExample | Example subsets of a Panobinostat TPP-CCR dataset (replicates 1 and 2) and the corresponding configuration table to start the analysis. |
hdacTR_config | The configuration table to analyze hdacTR_data. |
hdacTR_data | TPP-TR example dataset. |
hdacTR_resultsTable_smallExample | Example of a TPP-TR result table. |
hdacTR_smallExample | Example subset of a Panobinostat TPP-TR dataset and the corresponding configuration table to start the analysis. |
panob2D_isobQuant_example | Example subsets of a Panobinostat 2D-TPP dataset and the corresponding configuration table to start the analysis. |
panobinostat_2DTPP_config | The configuration table to analyze panobinostat_2DTPP_data. |
panobinostat_2DTPP_data | 2D-TPP-CCR example dataset |
resultTable | Example of a TPP-TR result table. |
TPP | Thermal proteome profiling (TPP) |
tpp2dAddAdditionalInfo | Add additional info to 2D-TPP CCR output data |
tpp2dCalcFractAbundance | Calculate fractional abundance and DMSO ratio of successive sumionareas (usage of function is only reasonable when at least two temperatures are multiplexed!) |
tpp2dComputeFoldChanges | Compute 2D-TPP fold changes |
tpp2dCreateCCRConfigFile | Create TPP-CCR config files for 2D-TPP experiment |
tpp2dCreateDataFrameList | Create data frame list for 2D-TPP experiment |
tpp2dCreateReport | Create Report of 2D-TPP analysis |
tpp2dCreateTPPTRreference | Create TPP-TR reference for 2D-TPP experiment |
tpp2dCurveFit | Run TPP-CCR analysis for 2D-TPP experiment |
tpp2dEvalConfigTable | Evaluation of 2D-TPP Configuration File |
tpp2dExport | Produce Excel table of 2D-TPP experiment. |
tpp2dExportPlots | Export plots for 2D-TPP experiment. |
tpp2dImport | Import 2D-TPP data |
tpp2dMerge2dRef | Merge 2D-TPP result data with TPP-TR reference data |
tpp2dNormalize | Median normalization of protein fold changes of 2D-TPP data |
tpp2dPlotCCRAllCurves | Plot all 2D-TPP CCR curves |
tpp2dPlotCCRGoodCurves | Plot 2D-TPP CCR curves meeting the requirements |
tpp2dPlotCCRSingleCurves | Plot single 2D-TPP CCR curves |
tpp2dPlotQChist | Plot quality control histograms |
tpp2dPlotQCpEC50 | Plot quality control pEC50 plots |
tpp2dRemoveNAs | Remove NAs in 2D-TPP data |
tpp2dRemoveZeroSias | Remove rows with zero sumionarea values |
tpp2dReplaceColNames | Replace column names for 2D-TPP data |
tpp2dSplineFitAndTest | Fit splines and perform f-Test |
tpp2dSplinePlot | Fit splines and generate ggplot visualizations |
tpp2dTRReferenceObject | TPP-TR reference object |
tppccrCurveFit | Fit dose response curves |
tppccrImport | Import TPP-CCR dataset for analysis by the 'TPP' package. |
tppccrNormalize | Normalize data from TPP-CCR experiments |
tppccrNormalizeToReference | Normalize fold changes of TPP-CCR experiment to a reference column |
tppccrPlotCurves | Plot dose response curves |
tppccrResultTable | Summarize results of a TPP-CCR study |
tppccrTransform | Transform fold changes of TPP-CCR experiment |
tppDefaultTheme | Default ggplot theme for melting curve plots. |
tppExport | Produce Excel table of TPP-TR or TPP-CCR experiment. |
tppQCPlotsCorrelateExperiments | Visually compare fold changes of different TPP experiments. |
tpptrAnalyzeMeltingCurves | Analyze fitted curve parameters to detect significant shifts in melting points. |
tpptrCurveFit | Fit melting curves to all proteins in a dataset. |
tpptrDefaultNormReqs | Default filter criteria for fold change normalization |
tpptrFitSplines | Perform spline fitting |
tpptrFTest | Analyze spline fits to detect differential behavior over time |
tpptrImport | Import TPP-TR datasets for analysis by the 'TPP' package. |
tpptrNormalize | Normalize protein fold changes |
tpptrPlotSplines | Plot spline fits per protein |
tpptrSplineFitAndTest | Perform spline fitting and analyze by moderated F-test |
tpptrTidyUpESets | Tidy up expressionSets |