Package: RPBC
Title: Region-Preserving Batch Correction for Paired Region-Resolved
        Single-Cell Data
Version: 0.99.1
Authors@R: 
    person(
        given = "Elizabeth B.",
        family = "Amona",
        email = "amonaelizabeth1@gmail.com",
        role = c("aut", "cre"),
        comment = c(ORCID = "0000-0002-7575-788X")
    )
Description: Implements Region-Preserving Batch Correction (RPBC), an
    empirical-Bayes location-scale framework for paired region-resolved
    single-cell and spatial-omics data. RPBC preserves a patient-balanced
    population-average regional contrast while harmonizing patient-wide
    location shifts, patient-specific regional deviations, and patient-region
    scale heterogeneity. The package also provides Adaptive RPBC for
    group-size-dependent stabilization of patient-region scale variation and
    covariate-adjusted RPBC for preserving prespecified patient-level
    covariate-associated variation during harmonization. RPBC is designed
    to interoperate with Bioconductor data structures for single-cell and
    spatial experiments.
License: MIT + file LICENSE
Encoding: UTF-8
Roxygen: list(markdown = TRUE)
Config/roxygen2/version: 8.1.0
biocViews: BatchEffect, Preprocessing, SingleCell, Spatial,
        StatisticalMethod
Suggests: BiocStyle, knitr, rmarkdown, testthat (>= 3.0.0)
Config/testthat/edition: 3
Imports: matrixStats, SingleCellExperiment, SpatialExperiment,
        SummarizedExperiment
Depends: R (>= 4.6.0)
VignetteBuilder: knitr
git_url: https://git.bioconductor.org/packages/RPBC
git_branch: devel
git_last_commit: 9d9dc19
git_last_commit_date: 2026-11-05
Repository: Bioconductor 3.24
Date/Publication: 2026-11-09
NeedsCompilation: no
Packaged: 2026-11-10 03:40:29 UTC; biocbuild
Author: Elizabeth B. Amona [aut, cre] (ORCID:
    <https://orcid.org/0000-0002-7575-788X>)
Maintainer: Elizabeth B. Amona <amonaelizabeth1@gmail.com>
