Package: geneXtendeR
Type: Package
Version: 1.36.0
Title: Optimized Functional Annotation Of ChIP-seq Data
Description: geneXtendeR optimizes the functional annotation of
        ChIP-seq peaks by exploring relative differences in annotating
        ChIP-seq peak sets to variable-length gene bodies.  In contrast
        to prior techniques, geneXtendeR considers peak annotations
        beyond just the closest gene, allowing users to see peak
        summary statistics for the first-closest gene, second-closest
        gene, ..., n-closest gene whilst ranking the output according
        to biologically relevant events and iteratively comparing the
        fidelity of peak-to-gene overlap across a user-defined range of
        upstream and downstream extensions on the original boundaries
        of each gene's coordinates.  Since different ChIP-seq peak
        callers produce different differentially enriched peaks with a
        large variance in peak length distribution and total peak
        count, annotating peak lists with their nearest genes can often
        be a noisy process.  As such, the goal of geneXtendeR is to
        robustly link differentially enriched peaks with their
        respective genes, thereby aiding experimental follow-up and
        validation in designing primers for a set of prospective gene
        candidates during qPCR.
Authors@R: c(
        person("Bohdan", "Khomtchouk", email = "khomtchoukmed@gmail.com", role = c("aut", "cre")), 
        person("William", "Koehler", email = "williamk03hler@gmail.com", role = c("aut"))
            )
Maintainer: Bohdan Khomtchouk <khomtchoukmed@gmail.com>
URL: https://github.com/Bohdan-Khomtchouk/geneXtendeR
BugReports: https://github.com/Bohdan-Khomtchouk/geneXtendeR/issues
Depends: rtracklayer, GO.db, R (>= 3.5.0)
Imports: data.table, dplyr, graphics, networkD3, RColorBrewer,
        SnowballC, tm, utils, wordcloud, AnnotationDbi, BiocStyle,
        org.Rn.eg.db
Suggests: knitr, rmarkdown, testthat, org.Ag.eg.db, org.Bt.eg.db,
        org.Ce.eg.db, org.Cf.eg.db, org.Dm.eg.db, org.Dr.eg.db,
        org.Gg.eg.db, org.Hs.eg.db, org.Mm.eg.db, org.Pt.eg.db,
        org.Sc.sgd.db, org.Ss.eg.db, org.Xl.eg.db, rtracklayer
VignetteBuilder: knitr
License: GPL (>= 3)
LazyData: TRUE
biocViews: ChIPSeq, Genetics, Annotation, GenomeAnnotation,
        DifferentialPeakCalling, Coverage, PeakDetection, ChipOnChip,
        HistoneModification, DataImport, NaturalLanguageProcessing,
        Visualization, GO, Software
RoxygenNote: 6.1.0
NeedsCompilation: yes
Encoding: UTF-8
Config/pak/sysreqs: libglpk-dev make libbz2-dev libicu-dev liblzma-dev
        libpng-dev libxml2-dev libssl-dev
Repository: https://bioc-release.r-universe.dev
Date/Publication: 2025-10-29 14:34:47 UTC
RemoteUrl: https://github.com/bioc/geneXtendeR
RemoteRef: RELEASE_3_22
RemoteSha: d65d2af0a8651f3b896f8ad56878462d3c7c6116
Packaged: 2025-11-11 19:20:00 UTC; root
Author: Bohdan Khomtchouk [aut, cre],
  William Koehler [aut]
Built: R 4.5.2; x86_64-w64-mingw32; 2025-11-11 19:26:43 UTC; windows
Archs: x64
