Package: KBoost
Type: Package
Title: Inference of gene regulatory networks from gene expression data
Version: 1.18.0
Authors@R: c(
    person(given = "Luis F.",
           family = "Iglesias-Martinez",
           role = c("aut", "cre"),
           email = "luis.iglesiasmartinez@ucd.ie",
           comment = c(ORCID = "0000-0002-9110-2189")),
    person(given = "Barbara",
           family = "de Kegel",
           role = "aut"),
    person(given = "Walter",
           family = "Kolch",
           role = "aut"))
Description: Reconstructing gene regulatory networks and transcription
        factor activity is crucial to understand biological processes
        and holds potential for developing personalized treatment. Yet,
        it is still an open problem as state-of-art algorithm are often
        not able to handle large amounts of data. Furthermore, many of
        the present methods predict numerous false positives and are
        unable to integrate other sources of information such as
        previously known interactions. Here we introduce KBoost, an
        algorithm that uses kernel PCA regression, boosting and
        Bayesian model averaging for fast and accurate reconstruction
        of gene regulatory networks. KBoost can also use a prior
        network built on previously known transcription factor targets.
        We have benchmarked KBoost using three different datasets
        against other high performing algorithms. The results show that
        our method compares favourably to other methods across
        datasets.
Depends: R (>= 4.1), stats, utils
License: GPL-2 | GPL-3
Encoding: UTF-8
LazyData: true
RoxygenNote: 7.1.1
URL: https://github.com/Luisiglm/KBoost
biocViews: Network, GraphAndNetwork, Bayesian, NetworkInference,
        GeneRegulation, Transcriptomics, SystemsBiology, Transcription,
        GeneExpression, Regression, PrincipalComponent
Suggests: knitr, rmarkdown, testthat
VignetteBuilder: knitr
Repository: https://bioc-release.r-universe.dev
Date/Publication: 2025-10-29 15:09:43 UTC
RemoteUrl: https://github.com/bioc/KBoost
RemoteRef: RELEASE_3_22
RemoteSha: c7af30f43d74500b2053781251cabb5c214af155
NeedsCompilation: no
Packaged: 2026-02-03 08:18:01 UTC; root
Author: Luis F. Iglesias-Martinez [aut, cre] (ORCID:
    <https://orcid.org/0000-0002-9110-2189>),
  Barbara de Kegel [aut],
  Walter Kolch [aut]
Maintainer: Luis F. Iglesias-Martinez <luis.iglesiasmartinez@ucd.ie>
Built: R 4.5.2; ; 2026-02-03 08:19:08 UTC; windows
