GOfuncR

Gene ontology enrichment using FUNC


Bioconductor version: Release (3.19)

GOfuncR performs a gene ontology enrichment analysis based on the ontology enrichment software FUNC. GO-annotations are obtained from OrganismDb or OrgDb packages ('Homo.sapiens' by default); the GO-graph is included in the package and updated regularly (01-May-2021). GOfuncR provides the standard candidate vs. background enrichment analysis using the hypergeometric test, as well as three additional tests: (i) the Wilcoxon rank-sum test that is used when genes are ranked, (ii) a binomial test that is used when genes are associated with two counts and (iii) a Chi-square or Fisher's exact test that is used in cases when genes are associated with four counts. To correct for multiple testing and interdependency of the tests, family-wise error rates are computed based on random permutations of the gene-associated variables. GOfuncR also provides tools for exploring the ontology graph and the annotations, and options to take gene-length or spatial clustering of genes into account. It is also possible to provide custom gene coordinates, annotations and ontologies.

Author: Steffi Grote

Maintainer: Steffi Grote <grote.steffi at gmail.com>

Citation (from within R, enter citation("GOfuncR")):

Installation

To install this package, start R (version "4.4") and enter:


if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("GOfuncR")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("GOfuncR")
Introduction to GOfuncR HTML R Script
Reference Manual PDF
NEWS Text

Details

biocViews GO, GeneSetEnrichment, Software
Version 1.24.0
In Bioconductor since BioC 3.7 (R-3.5) (6.5 years)
License GPL (>= 2)
Depends R (>= 3.4), vioplot (>= 0.2)
Imports Rcpp (>= 0.11.5), mapplots (>= 1.5), gtools (>= 3.5.0), GenomicRanges(>= 1.28.4), IRanges, AnnotationDbi, utils, grDevices, graphics, stats
System Requirements
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Suggests Homo.sapiens, BiocStyle, knitr, markdown, rmarkdown, testthat
Linking To Rcpp
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Depends On Me
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Package Archives

Follow Installation instructions to use this package in your R session.

Source Package GOfuncR_1.24.0.tar.gz
Windows Binary GOfuncR_1.24.0.zip
macOS Binary (x86_64) GOfuncR_1.24.0.tgz
macOS Binary (arm64) GOfuncR_1.24.0.tgz
Source Repository git clone https://git.bioconductor.org/packages/GOfuncR
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/GOfuncR
Bioc Package Browser https://code.bioconductor.org/browse/GOfuncR/
Package Short Url https://bioconductor.org/packages/GOfuncR/
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