DOI: 10.18129/B9.bioc.NPARC  

This package is for version 3.17 of Bioconductor; for the stable, up-to-date release version, see NPARC.

Non-parametric analysis of response curves for thermal proteome profiling experiments

Bioconductor version: 3.17

Perform non-parametric analysis of response curves as described by Childs, Bach, Franken et al. (2019): Non-parametric analysis of thermal proteome profiles reveals novel drug-binding proteins.

Author: Dorothee Childs, Nils Kurzawa

Maintainer: Nils Kurzawa <nilskurzawa at>

Citation (from within R, enter citation("NPARC")):


To install this package, start R (version "4.3") and enter:

if (!require("BiocManager", quietly = TRUE))


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:



HTML R Script Analysing thermal proteome profiling data with the NPARC package
PDF   Reference Manual
Text   NEWS


biocViews Proteomics, Software
Version 1.12.0
In Bioconductor since BioC 3.11 (R-4.0) (3.5 years)
License GPL-3
Depends R (>= 4.0.0)
Imports dplyr, tidyr, BiocParallel, broom, MASS, rlang, magrittr, stats, methods
Suggests testthat, devtools, knitr, rprojroot, rmarkdown, ggplot2, BiocStyle
Depends On Me
Imports Me
Suggests Me
Links To Me
Build Report  

Package Archives

Follow Installation instructions to use this package in your R session.

Source Package NPARC_1.12.0.tar.gz
Windows Binary
macOS Binary (x86_64) NPARC_1.12.0.tgz
macOS Binary (arm64) NPARC_1.12.0.tgz
Source Repository git clone
Source Repository (Developer Access) git clone
Bioc Package Browser
Package Short Url
Package Downloads Report Download Stats

Documentation »


R / CRAN packages and documentation

Support »

Please read the posting guide. Post questions about Bioconductor to one of the following locations: