Changes in version 1.3.0 Bioc 3.16 release with the addition of a noise analysis function. Changes in version 1.2.0 Same as 1.1.0 but released on Bioc 3.15 Changes in version 1.1.0 Bioc 3.14 release Changes in version 1.0.1 Updated with RLHub update. Added 118 new samples to the database. Changes in version 1.0.0 First official release on bioconductor -- link. Changes in version 0.99.11 Pre-release. This version is prior to the first official release (v1.0.0), anticipated in Oct. 2021. Package - Base class - RLRanges stores R-loop data and RLSeq results. - Workflow -The wrapper function RLSeq() performs all analysis steps. However, individual functions are also accessible. - Model - The model for predicting sample quality label is updated to the latest version, incorporating 231 samples in training. This model showed high accuracy (.9304) on a test set of 115 samples.