CHANGES IN VERSION 1.3.3 ----------------------- NEW FEATURES o Add a new function ('xPierROCR') for assessing the dTarget performance via ROC and Precision-Recall (PR) analysis CHANGES IN VERSION 1.3.2 ----------------------- NEW FEATURES o Define S3 classes ('pNode', 'eTarget', 'dTarget', 'sTarget', 'cTarget', etc) CHANGES IN VERSION 1.1.5 ----------------------- NEW FEATURES o Add new functions ('xMLdotplot', 'xMLdensity', 'xMLzoom') for visualising machine learning results o Add a new function ('xGSsimulator') for simulating gold standard negatives o Add new functions ('xPierGSEA', 'xGSEAdotplot', 'xGSEAbarplot') for gene set enrichment analysis of prioritisation results CHANGES IN VERSION 1.1.3 ----------------------- NEW FEATURES o Initialise integral functions ('xMLrandomforest') for machine learning o Allow parallel computing on Windows o Speed up the calculation of defining and scoring seed genes from SNP or genomic regions CHANGES IN VERSION 1.1.1 ----------------------- NEW FEATURES o Add new functions ('xPredictROCR', 'xPredictCompare', 'xContour') for performance evaluation o Add new functions ('xSNPhic.r', 'xPCHiCplot.r') for dealing with promoter capture HiC data o Modify the function 'xPierSNPs.r' to incorporate promoter capture HiC data CHANGES IN VERSION 1.0.0 ----------------------- NEW FEATURES o A genomic-led target prioritisation system o Leveraging genetic data to prioritise targets at the gene, pathway and network level