CHANGES IN VERSION 0.99 ---------------------- NEW FEATURES o Initial release. CHANGES IN VERSION 0.99-1 ---------------------- o Fixed a bug in newSeqCountSet in dealing with the input experimental designs. o Fixed a bug in computing local FDR. o Add options to model the relationship between dispersion and mean expression. CHANGES IN VERSION 1.2.0-1 ---------------------- o Fixed a bug in computing local FDR. o Change the way to deal with genes with all 0 counts. Now the FDRs for these genes are assigned as 0. CHANGES IN VERSION 1.6.0 ---------------------- o Implemented methods for detecting differentially methylated loci (DML). CHANGES IN VERSION 1.7.0 ---------------------- o Added functionalities for multiple factor experimental design. Currently edgeR functions are used for glm fitting and hypothesis testing. DSS only provide functions for dispersion estimation. CHANGES IN VERSION 2.5.0 ---------------------- o Implemented methods for detecting differentially methylated regions (DMR). CHANGES IN VERSION 2.6.0 ---------------------- o Modified the algorithm for computing variances with smoothing. CHANGES IN VERSION 2.8.0 ---------------------- o Add function to detect DML for general experimental design.