calcDis {dStruct} | R Documentation |
d score of a nucleotide is a measure of dissimilarity of its normalized reactivity scores. Consider a transcript and its reactivity profiles from a group of samples. Then, the d score of a nucleotide is (2/π) times the arc-tangent of the ratio of the sample standard deviation of its reactivities to their mean.
calcDis(x)
x |
A numeric vector or matrix. |
If input is a numeric vector, a number is returned. For a matrix, a numeric vector is returned.
Krishna Choudhary
Choudhary, K., Lai, Y. H., Tran, E. J., & Aviran, S. (2019). dStruct: identifying differentially reactive regions from RNA structurome profiling data. Genome biology, 20(1), 1-26.
Choudhary K, Shih NP, Deng F, Ledda M, Li B, Aviran S. Metrics for rapid quality control in RNA structure probing experiments. Bioinformatics. 2016; 32(23):3575–3583.
#Lower standard deviation of reactivites results in lower d-score. calcDis(rnorm(10, 1, 0.2)) calcDis(rnorm(10, 1, 0.6))