computeFc {bnem} | R Documentation |
computes differential effects given an activation pattern (absolute gene expression or truth table)
computeFc(CNOlist, y)
CNOlist |
CNOlist object (see package CellNOptR), if available. |
y |
activation pattern according to the annotation in CNOlist |
numeric matrix with annotated response scheme
Martin Pirkl
sifMatrix <- rbind(c("A", 1, "B"), c("A", 1, "C"), c("B", 1, "D"), c("C", 1, "D")) temp.file <- tempfile(pattern="interaction",fileext=".sif") write.table(sifMatrix, file = temp.file, sep = "\t", row.names = FALSE, col.names = FALSE, quote = FALSE) PKN <- CellNOptR::readSIF(temp.file) CNOlist <- dummyCNOlist("A", c("B","C","D"), maxStim = 1, maxInhibit = 2, signals = c("A", "B","C","D")) model <- CellNOptR::preprocessing(CNOlist, PKN, maxInputsPerGate = 100) expression <- matrix(rnorm(nrow(slot(CNOlist, "cues"))*10), 10, nrow(slot(CNOlist, "cues"))) fc <- computeFc(CNOlist, expression)