Power_Disc {POWSC} | R Documentation |
Run DE analysis by using MAST. Here we output two result tables corresponding to two forms of DE genes. These parameters include four gene-wise parameters and two cell-wise parameters.
Power_Disc( DErslt, simData, alpha = 0.1, delta = 0.1, strata = seq(0, 1, by = 0.2) )
DErslt |
is from the DE analysis by MAST |
simData |
is the corresponding simulated scRNA-seq dataset (SingCellExperiment) |
alpha |
is the cutoff for the fdr which can be modified |
delta |
or the zero ratio change is the cutoff (=0.1) used to determined the high DE genes for Form II |
strata |
can be modified by the user. By default, it is (0, 0.2], (0.2, 0.4], (0.4, 0.6], (0.6, 0.8], (0.8, 1] |
a list of metrics for power analysis such as: stratified targeted power and marginal power.
data("es_mef_sce") sce = es_mef_sce[, colData(es_mef_sce)$cellTypes == "fibro"] set.seed(123) rix = sample(1:nrow(sce), 500) sce = sce[rix, ] estParas = Est2Phase(sce) simData = Simulate2SCE(n=1000, estParas1 = estParas, estParas2 = estParas) DErslt = runDE(simData$sce) Disc_pow = Power_Disc(DErslt, simData)