Welcome to MiDAS. This tutorial is supposed to help you get started with your analyses of immunogenetic associations. We will work with a simulated data set of 500 patients and 500 controls with a binary disease diagnosis.
We also have high resolution HLA alleles (4 - 6 digit), and presence/absence calls for KIR genes.
First, let’s import the phenotype data and HLA calls using MiDAS import functions. MiDAS will check for correct nomenclature of HLA. We can also define 4-digit resolution for HLA alleles as import format, which means that alleles with higher resolution will be reduced.
dat_pheno <-
read.table(
file = system.file("extdata", "MiDAS_tut_pheno.txt", package = "midasHLA"),
header = TRUE
)
dat_HLA <-
readHlaCalls(
file = system.file("extdata", "MiDAS_tut_HLA.txt", package = "midasHLA"),
resolution = 4
)
Let’s take a look at the imported HLA data tables:
ID | A_1 | A_2 | B_1 | B_2 | C_1 | C_2 | DPA1_1 | DPA1_2 | DPB1_1 | DPB1_2 | DQA1_1 | DQA1_2 | DQB1_1 | DQB1_2 | DRA_1 | DRA_2 | DRB1_1 | DRB1_2 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
C001 | A*25:01 | A*26:01 | B*07:02 | B*18:01 | C*12:03 | C*07:02 | DPA1*01:03 | DPA1*01:03 | DPB1*02:01 | DPB1*04:01 | DQA1*05:05 | DQA1*01:02 | DQB1*06:02 | DQB1*03:01 | DRA*01:02 | DRA*01:02 | DRB1*15:01 | DRB1*12:01 |
C002 | A*02:01 | A*02:324 | B*50:01 | B*18:01 | C*06:02 | C*12:03 | DPA1*01:03 | DPA1*01:03 | DPB1*04:02 | DPB1*04:02 | DQA1*02:01 | DQA1*05:05 | DQB1*02:02 | DQB1*03:01 | DRA*01:01 | DRA*01:01 | DRB1*07:01 | DRB1*11:04 |
C003 | A*24:02 | A*24:04 | B*46:01 | B*40:06 | C*01:03 | C*15:02 | DPA1*02:02 | DPA1*02:01 | DPB1*05:01 | DPB1*14:01 | DQA1*01:04 | DQA1*01:03 | DQB1*06:01 | DQB1*05:02 | DRA*01:02 | DRA*01:01 | DRB1*14:07 | DRB1*08:03 |
C004 | A*01:01 | A*24:02 | B*08:01 | B*15:01 | C*07:01 | C*03:03 | DPA1*01:03 | DPA1*01:03 | DPB1*04:01 | DPB1*03:01 | DQA1*01:03 | DQA1*01:02 | DQB1*06:04 | DQB1*06:03 | DRA*01:02 | DRA*01:01 | DRB1*13:01 | DRB1*13:02 |
C005 | A*01:01 | A*25:01 | B*18:01 | B*08:01 | C*12:03 | C*07:01 | DPA1*01:03 | DPA1*01:03 | DPB1*04:01 | DPB1*23:01 | DQA1*05:01 | DQA1*01:02 | DQB1*02:01 | DQB1*06:02 | DRA*01:02 | DRA*01:02 | DRB1*03:01 | DRB1*15:01 |
C006 | A*03:01 | A*01:01 | B*07:02 | B*08:01 | C*07:01 | C*07:02 | DPA1*01:03 | DPA1*01:03 | DPB1*57:01 | DPB1*271:01 | DQA1*01:02 | DQA1*01:01 | DQB1*06:04 | DQB1*05:01 | DRA*01:01 | DRA*01:02 | DRB1*13:02 | DRB1*01:02 |
C007 | A*01:01 | A*02:01 | B*15:01 | B*08:01 | C*07:01 | C*03:03 | DPA1*02:01 | DPA1*01:03 | DPB1*04:02 | DPB1*13:01 | DQA1*05:01 | DQA1*03:01 | DQB1*02:01 | DQB1*03:02 | DRA*01:01 | DRA*01:02 | DRB1*03:01 | DRB1*04:01 |
C008 | A*11:01 | A*02:01 | B*35:01 | B*27:05 | C*03:04 | C*04:01 | DPA1*01:03 | DPA1*01:03 | DPB1*04:01 | DPB1*04:01 | DQA1*03:03 | DQA1*01:02 | DQB1*06:04 | DQB1*03:01 | DRA*01:02 | DRA*01:01 | DRB1*13:02 | DRB1*04:01 |
C009 | A*23:01 | A*01:01 | B*13:02 | B*18:01 | C*07:01 | C*07:02 | DPA1*02:01 | DPA1*01:03 | DPB1*01:01 | DPB1*04:02 | DQA1*05:05 | DQA1*03:01 | DQB1*03:01 | DQB1*03:02 | DRA*01:01 | DRA*01:01 | DRB1*11:04 | DRB1*04:03 |
C010 | A*31:01 | A*02:06 | B*15:01 | B*56:01 | C*04:01 | C*03:03 | DPA1*02:02 | DPA1*02:02 | DPB1*05:01 | DPB1*05:01 | DQA1*03:02 | DQA1*03:02 | DQB1*03:03 | DQB1*03:96 | DRA*01:01 | DRA*01:01 | DRB1*09:01 | DRB1*09:01 |
C011 | A*02:01 | A*01:01 | B*07:02 | B*13:02 | C*06:02 | C*07:02 | DPA1*02:01 | DPA1*02:01 | DPB1*17:01 | DPB1*10:01 | DQA1*02:01 | DQA1*01:01 | DQB1*02:02 | DQB1*05:01 | DRA*01:01 | DRA*01:01 | DRB1*07:01 | DRB1*01:01 |
C012 | A*02:01 | A*02:01 | B*15:01 | B*27:02 | C*02:02 | C*03:03 | DPA1*01:03 | DPA1*01:03 | DPB1*04:01 | DPB1*04:01 | DQA1*01:02 | DQA1*03:01 | DQB1*03:02 | DQB1*05:02 | DRA*01:01 | DRA*01:01 | DRB1*04:04 | DRB1*16:01 |
C013 | A*02:05 | A*01:01 | B*49:01 | B*57:01 | C*07:01 | C*07:01 | DPA1*01:03 | DPA1*01:03 | DPB1*04:01 | DPB1*04:01 | DQA1*02:01 | DQA1*03:03 | DQB1*03:02 | DQB1*03:03 | DRA*01:01 | DRA*01:01 | DRB1*04:05 | DRB1*07:01 |
C014 | A*30:02 | A*01:01 | B*37:01 | B*27:05 | C*06:02 | C*02:02 | DPA1*02:01 | DPA1*01:03 | DPB1*02:01 | DPB1*10:01 | DQA1*03:01 | DQA1*03:03 | DQB1*04:02 | DQB1*03:02 | DRA*01:01 | DRA*01:01 | DRB1*04:03 | DRB1*04:04 |
C015 | A*02:642 | A*03:01 | B*07:02 | B*07:02 | C*07:02 | C*07:02 | DPA1*01:03 | DPA1*01:03 | DPB1*04:01 | DPB1*16:01 | DQA1*01:02 | DQA1*01:02 | DQB1*06:02 | DQB1*06:02 | DRA*01:02 | DRA*01:02 | DRB1*15:01 | DRB1*15:01 |
C016 | A*01:01 | A*68:01 | B*42:01 | B*08:156 | C*07:02 | C*07:01 | DPA1*01:03 | DPA1*01:03 | DPB1*04:01 | DPB1*02:01 | DQA1*05:01 | DQA1*01:02 | DQB1*02:01 | DQB1*06:02 | DRA*01:02 | DRA*01:02 | DRB1*03:01 | DRB1*15:01 |
C017 | A*03:01 | A*11:01 | B*08:01 | B*18:01 | C*05:01 | C*07:01 | DPA1*02:01 | DPA1*01:03 | DPB1*04:01 | DPB1*01:01 | DQA1*05:01 | DQA1*05:01 | DQB1*02:01 | DQB1*02:01 | DRA*01:01 | DRA*01:02 | DRB1*03:01 | DRB1*03:01 |
C018 | A*11:01 | A*02:01 | B*15:01 | B*37:01 | C*06:02 | C*04:01 | DPA1*01:03 | DPA1*02:02 | DPB1*04:01 | DPB1*05:01 | DQA1*01:03 | DQA1*01:05 | DQB1*06:01 | DQB1*05:01 | DRA*01:01 | DRA*01:02 | DRB1*10:01 | DRB1*08:03 |
C019 | A*02:10 | A*31:01 | B*54:01 | B*40:06 | C*08:01 | C*01:02 | DPA1*02:02 | DPA1*01:03 | DPB1*04:02 | DPB1*05:01 | DQA1*03:02 | DQA1*03:01 | DQB1*04:01 | DQB1*03:96 | DRA*01:01 | DRA*01:01 | DRB1*09:01 | DRB1*04:05 |
C020 | A*01:01 | A*29:02 | B*44:03 | B*08:01 | C*07:01 | C*16:01 | DPA1*02:01 | DPA1*02:02 | DPB1*01:01 | DPB1*10:01 | DQA1*02:01 | DQA1*05:01 | DQB1*02:01 | DQB1*02:02 | DRA*01:02 | DRA*01:01 | DRB1*07:01 | DRB1*03:01 |
Next, we want to check our HLA allele frequencies, and compare them to known frequencies from major populations. Here, we only include alleles with an allele frequency of 5% or higher in our study cohort. By default, MiDAS will output comparisons including the following populations, based on published data from allelefrequencies.net:
MiDAS comes with some pre-defined reference populations, but it is possible to customize these comparisons (see documentation).
allele | Counts | Freq | USA NMDP African American pop 2 | USA NMDP Chinese | USA NMDP European Caucasian | USA NMDP Hispanic South or Central American | USA NMDP Japanese | USA NMDP North American Amerindian | USA NMDP South Asian Indian |
---|---|---|---|---|---|---|---|---|---|
A*01:01 | 236 | 0.1180 | 0.0467 | 0.0145 | 0.1646 | 0.0726 | 0.0100 | 0.1202 | 0.1545 |
A*02:01 | 486 | 0.2430 | 0.1235 | 0.0946 | 0.2755 | 0.2095 | 0.1480 | 0.2776 | 0.0492 |
A*02:06 | 22 | 0.0110 | 0.0007 | 0.0349 | 0.0018 | 0.0198 | 0.0748 | 0.0275 | 0.0175 |
A*03:01 | 199 | 0.0995 | 0.0839 | 0.0140 | 0.1399 | 0.0738 | 0.0090 | 0.1044 | 0.0636 |
A*11:01 | 114 | 0.0570 | 0.0142 | 0.2752 | 0.0609 | 0.0456 | 0.0874 | 0.0488 | 0.1396 |
A*23:01 | 47 | 0.0235 | 0.1099 | 0.0021 | 0.0197 | 0.0368 | 0.0011 | 0.0181 | 0.0066 |
Let’s assume our cohort is of predominantly European ancestry. We can plot the following comparison to see if allele frequencies in our data are distributed as expected, for example by visualizing common HLA-A allele frequencies in comparison with European, Chinese, and African American reference populations:
freq_HLA_long <- gather(
data = freq_HLA,
key = "population",
value = "freq",
"Freq",
"USA NMDP European Caucasian",
"USA NMDP Chinese",
"USA NMDP African American pop 2",
factor_key = TRUE
) %>%
filter(grepl("^A", allele))
plot_HLAfreq <-
ggplot(data = freq_HLA_long, aes(x = allele, y = freq, fill = population)) +
geom_bar(
stat = "identity",
position = position_dodge(0.7),
width = 0.7,
colour = "black"
) +
coord_flip() +
scale_y_continuous(labels = formattable::percent)
plot_HLAfreq
The following function prepares our data for analysis, combining HLA and phenotypic data into one object. Here, we are interested in analyzing our data on the level of classical HLA alleles.
We can now test our HLA data for deviations from Hardy-Weinberg-Equilibrium (HWE) to filter out alleles that strongly deviate from HWE expectations (imputation or genotyping errors, …). Here, let’s remove alleles with a HWE p-value below 0.05 divided by the number of alleles tested / present in our data (N=447). We can create a filtered MiDAS object right away (as.MiDAS = TRUE
), as done in this example, or output actual HWE test results.
HLA <- HWETest(
object = HLA,
experiment = "hla_alleles",
HWE_cutoff = 0.05 / 447,
as.MiDAS = TRUE
)
Now, we define our statistical model and run the analysis. Since we want to test for association with disease status, we use a logistic regression approach. The term
is necessary as placeholder for the tested HLA alleles and needs to be included. It will become handy when for example defining more complex interaction models.
In the runMiDAS
function, we then refer to this model, choose our analysis type and define a inheritance model. Here we use dominant model, meaning that individuals will be defined as non-carriers (0) vs. carriers (1) for a given allele. Alternatively, it is also possible to choose recessive (0 = non-carrier or heterozygous carrier, 1 = homozygous carrier), overdominant (assuming heterozygous (dis)advantage: 0 = non-carrier or homozygous carrier, 1 = heterozygous carrier), or additive (N of alleles) inheritance models. Moreover, we define allele inclusion criteria, such that we only consider alleles frequencies above 2% and below 98%. We also apply the Bonferroni method to not only get nominal P values, but also such adjusted for multiple testing. For alternative multiple testing correction methods, as well as the option to choose a custom number of tests, please refer to the documentation. exponentiate = TRUE
means that the effect estimate will already be shown as odds ratio, since we use a logistic regression model.
HLA_model <- glm(disease ~ term, data = HLA, family = binomial())
HLA_results <- runMiDAS(
object = HLA_model,
experiment = "hla_alleles",
inheritance_model = "dominant",
lower_frequency_cutoff = 0.02,
upper_frequency_cutoff = 0.98,
correction = "bonferroni",
exponentiate = TRUE
)
kableResults(HLA_results)
allele | p.value | p.adjusted | estimate | std.error | conf.low | conf.high | statistic | Ntotal | Ntotal [%] | N(disease=0) | N(disease=0) [%] | N(disease=1) | N(disease=1) [%] |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DQB1*06:02 | 2.600e-06 | 2.290e-04 | 2.1719 | 0.1651 | 1.5764 | 3.0138 | 4.698e+00 | 198 | 9.90% | 69 | 6.90% | 129 | 12.90% |
DRB1*15:01 | 7.300e-06 | 6.386e-04 | 2.0649 | 0.1617 | 1.5081 | 2.8450 | 4.484e+00 | 206 | 10.30% | 74 | 7.40% | 132 | 13.20% |
B*57:01 | 3.080e-05 | 2.682e-03 | 2.9931 | 0.2631 | 1.8157 | 5.1189 | 4.167e+00 | 79 | 3.95% | 21 | 2.10% | 58 | 5.80% |
C*07:02 | 1.859e-04 | 1.618e-02 | 1.8227 | 0.1606 | 1.3334 | 2.5044 | 3.737e+00 | 204 | 10.20% | 78 | 7.80% | 126 | 12.60% |
B*18:01 | 6.012e-04 | 5.230e-02 | 0.5014 | 0.2012 | 0.3357 | 0.7400 | -3.431e+00 | 122 | 6.10% | 79 | 7.90% | 43 | 4.30% |
DRA*01:02 | 2.701e-03 | 2.350e-01 | 1.4703 | 0.1285 | 1.1435 | 1.8926 | 3.000e+00 | 573 | 28.65% | 263 | 26.30% | 310 | 31.00% |
DQB1*02:02 | 4.569e-03 | 3.975e-01 | 0.6257 | 0.1654 | 0.4513 | 0.8635 | -2.836e+00 | 185 | 9.25% | 110 | 11.00% | 75 | 7.50% |
B*51:01 | 4.863e-03 | 4.231e-01 | 1.7271 | 0.1941 | 1.1849 | 2.5396 | 2.816e+00 | 128 | 6.40% | 49 | 4.90% | 79 | 7.90% |
DRA*01:01 | 1.073e-02 | 9.331e-01 | 0.6210 | 0.1867 | 0.4289 | 0.8930 | -2.552e+00 | 862 | 43.10% | 445 | 44.50% | 417 | 41.70% |
B*44:02 | 2.068e-02 | 1.000e+00 | 1.4963 | 0.1742 | 1.0655 | 2.1111 | 2.314e+00 | 161 | 8.05% | 67 | 6.70% | 94 | 9.40% |
C*08:02 | 2.076e-02 | 1.000e+00 | 1.8030 | 0.2549 | 1.1023 | 3.0076 | 2.312e+00 | 71 | 3.55% | 26 | 2.60% | 45 | 4.50% |
DQA1*04:01 | 2.235e-02 | 1.000e+00 | 1.9179 | 0.2851 | 1.1089 | 3.4120 | 2.284e+00 | 57 | 2.85% | 20 | 2.00% | 37 | 3.70% |
DQB1*05:02 | 3.106e-02 | 1.000e+00 | 0.5645 | 0.2652 | 0.3313 | 0.9417 | -2.156e+00 | 65 | 3.25% | 41 | 4.10% | 24 | 2.40% |
DRB1*11:01 | 3.188e-02 | 1.000e+00 | 0.6651 | 0.1900 | 0.4565 | 0.9630 | -2.146e+00 | 131 | 6.55% | 77 | 7.70% | 54 | 5.40% |
DRB1*07:01 | 3.518e-02 | 1.000e+00 | 0.7266 | 0.1517 | 0.5390 | 0.9772 | -2.106e+00 | 228 | 11.40% | 128 | 12.80% | 100 | 10.00% |
A*31:01 | 6.065e-02 | 1.000e+00 | 1.6857 | 0.2784 | 0.9846 | 2.9492 | 1.876e+00 | 58 | 2.90% | 22 | 2.20% | 36 | 3.60% |
B*08:01 | 8.299e-02 | 1.000e+00 | 0.7130 | 0.1951 | 0.4847 | 1.0431 | -1.734e+00 | 122 | 6.10% | 70 | 7.00% | 52 | 5.20% |
DQA1*01:02 | 9.218e-02 | 1.000e+00 | 1.2555 | 0.1351 | 0.9637 | 1.6371 | 1.684e+00 | 327 | 16.35% | 151 | 15.10% | 176 | 17.60% |
B*07:02 | 1.037e-01 | 1.000e+00 | 1.3456 | 0.1825 | 0.9424 | 1.9292 | 1.627e+00 | 142 | 7.10% | 62 | 6.20% | 80 | 8.00% |
B*35:01 | 1.043e-01 | 1.000e+00 | 0.6811 | 0.2365 | 0.4254 | 1.0787 | -1.624e+00 | 80 | 4.00% | 47 | 4.70% | 33 | 3.30% |
DQB1*04:02 | 1.069e-01 | 1.000e+00 | 1.5610 | 0.2762 | 0.9141 | 2.7147 | 1.612e+00 | 58 | 2.90% | 23 | 2.30% | 35 | 3.50% |
DRB1*03:01 | 1.102e-01 | 1.000e+00 | 0.7737 | 0.1606 | 0.5639 | 1.0592 | -1.597e+00 | 194 | 9.70% | 107 | 10.70% | 87 | 8.70% |
DQA1*02:01 | 1.177e-01 | 1.000e+00 | 0.7913 | 0.1496 | 0.5895 | 1.0604 | -1.565e+00 | 235 | 11.75% | 128 | 12.80% | 107 | 10.70% |
C*03:03 | 1.291e-01 | 1.000e+00 | 0.6974 | 0.2374 | 0.4349 | 1.1070 | -1.518e+00 | 79 | 3.95% | 46 | 4.60% | 33 | 3.30% |
C*07:01 | 1.309e-01 | 1.000e+00 | 0.7952 | 0.1517 | 0.5901 | 1.0700 | -1.511e+00 | 226 | 11.30% | 123 | 12.30% | 103 | 10.30% |
DQB1*02:01 | 1.314e-01 | 1.000e+00 | 0.7860 | 0.1596 | 0.5740 | 1.0739 | -1.509e+00 | 197 | 9.85% | 108 | 10.80% | 89 | 8.90% |
DPB1*104:01 | 1.341e-01 | 1.000e+00 | 0.6295 | 0.3089 | 0.3380 | 1.1441 | -1.498e+00 | 46 | 2.30% | 28 | 2.80% | 18 | 1.80% |
DQA1*01:01 | 1.613e-01 | 1.000e+00 | 1.2610 | 0.1656 | 0.9122 | 1.7473 | 1.401e+00 | 179 | 8.95% | 81 | 8.10% | 98 | 9.80% |
DQB1*03:01 | 1.699e-01 | 1.000e+00 | 0.8355 | 0.1309 | 0.6461 | 1.0797 | -1.373e+00 | 373 | 18.65% | 197 | 19.70% | 176 | 17.60% |
A*02:01 | 1.796e-01 | 1.000e+00 | 1.1874 | 0.1280 | 0.9241 | 1.5265 | 1.342e+00 | 427 | 21.35% | 203 | 20.30% | 224 | 22.40% |
DQA1*05:05 | 2.041e-01 | 1.000e+00 | 0.8356 | 0.1414 | 0.6330 | 1.1022 | -1.270e+00 | 278 | 13.90% | 148 | 14.80% | 130 | 13.00% |
A*11:01 | 2.223e-01 | 1.000e+00 | 0.7788 | 0.2049 | 0.5194 | 1.1620 | -1.220e+00 | 108 | 5.40% | 60 | 6.00% | 48 | 4.80% |
DPA1*01:03 | 2.340e-01 | 1.000e+00 | 1.3315 | 0.2406 | 0.8330 | 2.1466 | 1.190e+00 | 924 | 46.20% | 457 | 45.70% | 467 | 46.70% |
DQB1*03:03 | 2.340e-01 | 1.000e+00 | 1.3315 | 0.2406 | 0.8330 | 2.1466 | 1.190e+00 | 76 | 3.80% | 33 | 3.30% | 43 | 4.30% |
DQA1*05:01 | 2.369e-01 | 1.000e+00 | 0.8294 | 0.1582 | 0.6076 | 1.1303 | -1.183e+00 | 201 | 10.05% | 108 | 10.80% | 93 | 9.30% |
A*25:01 | 2.563e-01 | 1.000e+00 | 0.7211 | 0.2881 | 0.4056 | 1.2630 | -1.135e+00 | 52 | 2.60% | 30 | 3.00% | 22 | 2.20% |
B*27:05 | 2.728e-01 | 1.000e+00 | 0.7374 | 0.2778 | 0.4239 | 1.2666 | -1.097e+00 | 56 | 2.80% | 32 | 3.20% | 24 | 2.40% |
DPB1*04:02 | 2.921e-01 | 1.000e+00 | 0.8426 | 0.1625 | 0.6120 | 1.1582 | -1.054e+00 | 187 | 9.35% | 100 | 10.00% | 87 | 8.70% |
A*03:01 | 2.960e-01 | 1.000e+00 | 1.1835 | 0.1612 | 0.8632 | 1.6250 | 1.045e+00 | 191 | 9.55% | 89 | 8.90% | 102 | 10.20% |
DPB1*17:01 | 2.973e-01 | 1.000e+00 | 0.7299 | 0.3020 | 0.3991 | 1.3139 | -1.042e+00 | 47 | 2.35% | 27 | 2.70% | 20 | 2.00% |
C*03:04 | 2.978e-01 | 1.000e+00 | 1.2747 | 0.2331 | 0.8086 | 2.0229 | 1.041e+00 | 81 | 4.05% | 36 | 3.60% | 45 | 4.50% |
DQA1*03:01 | 2.986e-01 | 1.000e+00 | 1.1981 | 0.1738 | 0.8526 | 1.6870 | 1.040e+00 | 158 | 7.90% | 73 | 7.30% | 85 | 8.50% |
DPB1*13:01 | 3.067e-01 | 1.000e+00 | 0.7390 | 0.2959 | 0.4093 | 1.3149 | -1.022e+00 | 49 | 2.45% | 28 | 2.80% | 21 | 2.10% |
DQA1*01:03 | 3.208e-01 | 1.000e+00 | 1.1970 | 0.1811 | 0.8398 | 1.7102 | 9.928e-01 | 143 | 7.15% | 66 | 6.60% | 77 | 7.70% |
DRB1*04:01 | 3.369e-01 | 1.000e+00 | 1.2288 | 0.2145 | 0.8079 | 1.8775 | 9.604e-01 | 97 | 4.85% | 44 | 4.40% | 53 | 5.30% |
DQB1*05:03 | 3.760e-01 | 1.000e+00 | 0.7680 | 0.2981 | 0.4239 | 1.3736 | -8.854e-01 | 48 | 2.40% | 27 | 2.70% | 21 | 2.10% |
DQA1*01:04 | 3.938e-01 | 1.000e+00 | 0.7831 | 0.2867 | 0.4426 | 1.3704 | -8.528e-01 | 52 | 2.60% | 29 | 2.90% | 23 | 2.30% |
A*32:01 | 4.177e-01 | 1.000e+00 | 0.8022 | 0.2720 | 0.4674 | 1.3647 | -8.104e-01 | 58 | 2.90% | 32 | 3.20% | 26 | 2.60% |
A*23:01 | 4.558e-01 | 1.000e+00 | 0.7993 | 0.3005 | 0.4394 | 1.4375 | -7.457e-01 | 47 | 2.35% | 26 | 2.60% | 21 | 2.10% |
DQB1*06:01 | 4.558e-01 | 1.000e+00 | 1.2512 | 0.3005 | 0.6956 | 2.2759 | 7.457e-01 | 47 | 2.35% | 21 | 2.10% | 26 | 2.60% |
B*40:01 | 4.958e-01 | 1.000e+00 | 1.2050 | 0.2738 | 0.7053 | 2.0743 | 6.812e-01 | 57 | 2.85% | 26 | 2.60% | 31 | 3.10% |
C*12:03 | 5.147e-01 | 1.000e+00 | 0.8856 | 0.1865 | 0.6135 | 1.2760 | -6.516e-01 | 133 | 6.65% | 70 | 7.00% | 63 | 6.30% |
DRB1*13:01 | 5.273e-01 | 1.000e+00 | 1.1428 | 0.2112 | 0.7557 | 1.7330 | 6.321e-01 | 100 | 5.00% | 47 | 4.70% | 53 | 5.30% |
A*29:02 | 5.379e-01 | 1.000e+00 | 0.8264 | 0.3096 | 0.4463 | 1.5145 | -6.159e-01 | 44 | 2.20% | 24 | 2.40% | 20 | 2.00% |
DRB1*01:01 | 5.622e-01 | 1.000e+00 | 0.8939 | 0.1934 | 0.6108 | 1.3059 | -5.795e-01 | 122 | 6.10% | 64 | 6.40% | 58 | 5.80% |
A*68:01 | 5.692e-01 | 1.000e+00 | 0.8499 | 0.2857 | 0.4823 | 1.4870 | -5.692e-01 | 52 | 2.60% | 28 | 2.80% | 24 | 2.40% |
B*44:03 | 5.709e-01 | 1.000e+00 | 0.8792 | 0.2271 | 0.5616 | 1.3720 | -5.667e-01 | 85 | 4.25% | 45 | 4.50% | 40 | 4.00% |
DRB1*13:02 | 5.750e-01 | 1.000e+00 | 1.1343 | 0.2247 | 0.7303 | 1.7673 | 5.607e-01 | 87 | 4.35% | 41 | 4.10% | 46 | 4.60% |
DRB1*11:04 | 5.789e-01 | 1.000e+00 | 0.8839 | 0.2224 | 0.5699 | 1.3666 | -5.550e-01 | 89 | 4.45% | 47 | 4.70% | 42 | 4.20% |
DQB1*03:02 | 6.084e-01 | 1.000e+00 | 1.0915 | 0.1709 | 0.7808 | 1.5273 | 5.123e-01 | 164 | 8.20% | 79 | 7.90% | 85 | 8.50% |
B*13:02 | 6.202e-01 | 1.000e+00 | 0.8843 | 0.2483 | 0.5415 | 1.4384 | -4.955e-01 | 70 | 3.50% | 37 | 3.70% | 33 | 3.30% |
DPA1*02:01 | 6.217e-01 | 1.000e+00 | 0.9328 | 0.1410 | 0.7072 | 1.2298 | -4.935e-01 | 279 | 13.95% | 143 | 14.30% | 136 | 13.60% |
B*15:01 | 6.412e-01 | 1.000e+00 | 0.8969 | 0.2334 | 0.5659 | 1.4173 | -4.661e-01 | 80 | 4.00% | 42 | 4.20% | 38 | 3.80% |
DRB1*04:04 | 6.542e-01 | 1.000e+00 | 0.8745 | 0.2994 | 0.4829 | 1.5731 | -4.480e-01 | 47 | 2.35% | 25 | 2.50% | 22 | 2.20% |
B*38:01 | 6.665e-01 | 1.000e+00 | 0.8833 | 0.2880 | 0.4993 | 1.5537 | -4.310e-01 | 51 | 2.55% | 27 | 2.70% | 24 | 2.40% |
DQB1*06:04 | 7.083e-01 | 1.000e+00 | 1.0980 | 0.2498 | 0.6727 | 1.7976 | 3.742e-01 | 69 | 3.45% | 33 | 3.30% | 36 | 3.60% |
DPB1*03:01 | 7.087e-01 | 1.000e+00 | 0.9325 | 0.1869 | 0.6457 | 1.3454 | -3.736e-01 | 132 | 6.60% | 68 | 6.80% | 64 | 6.40% |
DPB1*02:01 | 7.233e-01 | 1.000e+00 | 0.9511 | 0.1417 | 0.7203 | 1.2555 | -3.541e-01 | 275 | 13.75% | 140 | 14.00% | 135 | 13.50% |
C*12:02 | 7.526e-01 | 1.000e+00 | 0.9053 | 0.3156 | 0.4842 | 1.6832 | -3.152e-01 | 42 | 2.10% | 22 | 2.20% | 20 | 2.00% |
A*24:02 | 7.586e-01 | 1.000e+00 | 1.0484 | 0.1537 | 0.7756 | 1.4176 | 3.074e-01 | 216 | 10.80% | 106 | 10.60% | 110 | 11.00% |
C*05:01 | 7.899e-01 | 1.000e+00 | 0.9538 | 0.1776 | 0.6728 | 1.3513 | -2.664e-01 | 149 | 7.45% | 76 | 7.60% | 73 | 7.30% |
DPB1*01:01 | 8.067e-01 | 1.000e+00 | 0.9419 | 0.2448 | 0.5814 | 1.5231 | -2.446e-01 | 72 | 3.60% | 37 | 3.70% | 35 | 3.50% |
C*02:02 | 8.215e-01 | 1.000e+00 | 1.0522 | 0.2256 | 0.6756 | 1.6408 | 2.256e-01 | 86 | 4.30% | 42 | 4.20% | 44 | 4.40% |
C*01:02 | 8.316e-01 | 1.000e+00 | 1.0463 | 0.2128 | 0.6891 | 1.5902 | 2.127e-01 | 98 | 4.90% | 48 | 4.80% | 50 | 5.00% |
DQB1*06:03 | 8.385e-01 | 1.000e+00 | 1.0424 | 0.2038 | 0.6987 | 1.5563 | 2.038e-01 | 108 | 5.40% | 53 | 5.30% | 55 | 5.50% |
DQB1*05:01 | 8.724e-01 | 1.000e+00 | 1.0261 | 0.1606 | 0.7489 | 1.4063 | 1.606e-01 | 192 | 9.60% | 95 | 9.50% | 97 | 9.70% |
A*30:02 | 8.761e-01 | 1.000e+00 | 0.9526 | 0.3119 | 0.5141 | 1.7603 | -1.559e-01 | 43 | 2.15% | 22 | 2.20% | 21 | 2.10% |
DRB1*04:05 | 8.812e-01 | 1.000e+00 | 1.0457 | 0.2989 | 0.5806 | 1.8875 | 1.494e-01 | 47 | 2.35% | 23 | 2.30% | 24 | 2.40% |
C*15:02 | 8.812e-01 | 1.000e+00 | 0.9563 | 0.2989 | 0.5298 | 1.7224 | -1.494e-01 | 47 | 2.35% | 24 | 2.40% | 23 | 2.30% |
C*16:01 | 8.835e-01 | 1.000e+00 | 0.9580 | 0.2930 | 0.5370 | 1.7054 | -1.465e-01 | 49 | 2.45% | 25 | 2.50% | 24 | 2.40% |
DQA1*03:03 | 9.248e-01 | 1.000e+00 | 0.9824 | 0.1887 | 0.6781 | 1.4227 | -9.434e-02 | 129 | 6.45% | 65 | 6.50% | 64 | 6.40% |
C*06:02 | 9.348e-01 | 1.000e+00 | 0.9867 | 0.1636 | 0.7158 | 1.3601 | -8.178e-02 | 183 | 9.15% | 92 | 9.20% | 91 | 9.10% |
C*04:01 | 9.396e-01 | 1.000e+00 | 1.0115 | 0.1515 | 0.7516 | 1.3615 | 7.573e-02 | 225 | 11.25% | 112 | 11.20% | 113 | 11.30% |
B*49:01 | 1.000e+00 | 1.000e+00 | 1.0000 | 0.3153 | 0.5367 | 1.8633 | 0.000e+00 | 42 | 2.10% | 21 | 2.10% | 21 | 2.10% |
A*26:01 | 1.000e+00 | 1.000e+00 | 1.0000 | 0.2232 | 0.6447 | 1.5510 | 0.000e+00 | 88 | 4.40% | 44 | 4.40% | 44 | 4.40% |
B*52:01 | 1.000e+00 | 1.000e+00 | 1.0000 | 0.3153 | 0.5367 | 1.8633 | 0.000e+00 | 42 | 2.10% | 21 | 2.10% | 21 | 2.10% |
A*01:01 | 1.000e+00 | 1.000e+00 | 1.0000 | 0.1522 | 0.7419 | 1.3479 | 0.000e+00 | 222 | 11.10% | 111 | 11.10% | 111 | 11.10% |
Three HLA alleles show significant association with the disease after multiple testing adjustment. Due to the complex linkage disequilibrium structure in the MHC, it is likely that associations are not statistically independent. The two alleles HLA-DRB1*15:01 and HLA-DQB1*06:02 are a common class II haplotype. We can therefore test if there are associations that are statistically independent of our top-associated allele, by setting the conditional
flag to TRUE
. MiDAS will now perform stepwise conditional testing until the top associated allele does not reach a defined significance threshold (here th = 0.05
, based on adjusted p value).
HLA_results_cond <- runMiDAS(
object = HLA_model,
experiment = "hla_alleles",
inheritance_model = "dominant",
conditional = TRUE,
lower_frequency_cutoff = 0.02,
upper_frequency_cutoff = 0.98,
correction = "bonferroni",
exponentiate = TRUE
)
kableResults(HLA_results_cond, scroll_box_height = "200px")
allele | p.value | p.adjusted | estimate | std.error | conf.low | conf.high | statistic | covariates | Ntotal | Ntotal [%] | N(disease=0) | N(disease=0) [%] | N(disease=1) | N(disease=1) [%] |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DQB1*06:02 | 2.60e-06 | 2.290e-04 | 2.172 | 0.1651 | 1.576 | 3.014 | 4.698 | 198 | 9.90% | 69 | 6.90% | 129 | 12.90% | |
B*57:01 | 2.64e-05 | 2.269e-03 | 3.049 | 0.2653 | 1.841 | 5.235 | 4.203 | DQB1*06:02 | 79 | 3.95% | 21 | 2.10% | 58 | 5.80% |
The results for conditional testing are displayed in a way that for each step the top associated allele is shown, along with a list of alleles conditioned on.
As we can see, HLA-DRB1*15:01 was not independently associated with the disease when correcting for our top-associated allele HLA-DQB1*06:02. However, HLA-B*57:01 can be considered an independent association signal.
Next, we want to find out what are the strongest associated amino acid positions, corresponding to our allele-level associations. This can help fine-mapping the associated variants to e.g. the peptide binding region or other functionally distinct parts of the protein. We thus prepare a MiDAS object with experiment type “hla_aa”, which includes the inference of amino acid variation from allele calls.
Amino acid data will be stored in a MiDAS object, but we can extract it to a data frame and select a couple of variables to display how this looks like:
dat_HLA_AA <- HLA_AA[["hla_aa"]] %>%
assay() %>%
t() %>%
as.data.frame() %>%
select(starts_with("B_97_")) %>%
head()
B_97_S | B_97_R | B_97_T | B_97_N | B_97_V | B_97_W | |
---|---|---|---|---|---|---|
C001 | 1 | 1 | 0 | 0 | 0 | 0 |
C002 | 0 | 2 | 0 | 0 | 0 | 0 |
C003 | 0 | 1 | 1 | 0 | 0 | 0 |
C004 | 1 | 1 | 0 | 0 | 0 | 0 |
C005 | 1 | 1 | 0 | 0 | 0 | 0 |
C006 | 2 | 0 | 0 | 0 | 0 | 0 |
Now, we run the association test based on amino acid variation. To first identify the most relevant associated amino acid positions, we run a likelihood ratio (omnibus) test, which groups all residues at each amino acid position.
HLA_AA_model <- glm(disease ~ term, data = HLA_AA, family = binomial())
HLA_AA_omnibus_results <- runMiDAS(
HLA_AA_model,
experiment = "hla_aa",
inheritance_model = "dominant",
conditional = FALSE,
omnibus = TRUE,
lower_frequency_cutoff = 0.02,
upper_frequency_cutoff = 0.98,
correction = "bonferroni"
)
kableResults(HLA_AA_omnibus_results)
aa_pos | residues | df | statistic | p.value | p.adjusted |
---|---|---|---|---|---|
B_97 | S, R, T, N, V, W | 6 | 3.532e+01 | 3.700e-06 | 1.689e-03 |
DQB1_9 | F, Y, L | 3 | 2.645e+01 | 7.700e-06 | 3.476e-03 |
DRB1_-1 | S, A | 2 | 1.706e+01 | 1.973e-04 | 8.937e-02 |
B_81 | L, A | 2 | 1.689e+01 | 2.154e-04 | 9.760e-02 |
B_80 | N, T, I | 3 | 1.866e+01 | 3.209e-04 | 1.454e-01 |
B_82 | R, L | 2 | 1.582e+01 | 3.674e-04 | 1.664e-01 |
B_83 | G, R | 2 | 1.582e+01 | 3.674e-04 | 1.664e-01 |
B_282 | V, I | 2 | 1.518e+01 | 5.044e-04 | 2.285e-01 |
B_62 | R, G | 2 | 1.511e+01 | 5.232e-04 | 2.370e-01 |
DRB1_71 | A, R, E, K | 4 | 1.984e+01 | 5.362e-04 | 2.429e-01 |
B_77 | S, N, D | 3 | 1.717e+01 | 6.530e-04 | 2.958e-01 |
B_65 | Q, R | 2 | 1.385e+01 | 9.828e-04 | 4.452e-01 |
B_70 | Q, N, K, S | 4 | 1.849e+01 | 9.909e-04 | 4.489e-01 |
B_306 | A, T | 2 | 1.357e+01 | 1.128e-03 | 5.110e-01 |
B_66 | I, N | 2 | 1.330e+01 | 1.294e-03 | 5.861e-01 |
DQB1_135 | D, G | 2 | 1.323e+01 | 1.342e-03 | 6.080e-01 |
B_103 | V, L | 2 | 1.296e+01 | 1.537e-03 | 6.961e-01 |
B_326 | C, S | 2 | 1.286e+01 | 1.616e-03 | 7.320e-01 |
B_30 | D, G | 2 | 1.283e+01 | 1.637e-03 | 7.414e-01 |
DQB1_-18 | V, A | 2 | 1.267e+01 | 1.772e-03 | 8.029e-01 |
DQB1_55 | R, L, P | 3 | 1.420e+01 | 2.647e-03 | 1.000e+00 |
C_99 | Y, C, F, S | 4 | 1.624e+01 | 2.714e-03 | 1.000e+00 |
DRA_217 | L, V | 2 | 1.173e+01 | 2.830e-03 | 1.000e+00 |
DQB1_77 | T, R | 2 | 1.170e+01 | 2.886e-03 | 1.000e+00 |
B_9 | Y, H, D | 3 | 1.370e+01 | 3.340e-03 | 1.000e+00 |
B_69 | A, T | 2 | 1.122e+01 | 3.661e-03 | 1.000e+00 |
DQB1_38 | A, V | 2 | 1.081e+01 | 4.489e-03 | 1.000e+00 |
DQB1_-5 | L, P, S | 3 | 1.300e+01 | 4.636e-03 | 1.000e+00 |
B_67 | Y, S, F, C, M | 5 | 1.666e+01 | 5.181e-03 | 1.000e+00 |
B_71 | A, T | 2 | 1.044e+01 | 5.405e-03 | 1.000e+00 |
DQB1_87 | F, L, Y | 3 | 1.258e+01 | 5.649e-03 | 1.000e+00 |
DQB1_125 | G, A, S | 3 | 1.249e+01 | 5.868e-03 | 1.000e+00 |
DRB1_133 | L, R | 2 | 9.754e+00 | 7.618e-03 | 1.000e+00 |
DRB1_142 | M, V | 2 | 9.754e+00 | 7.618e-03 | 1.000e+00 |
DQB1_30 | Y, S, H | 3 | 1.148e+01 | 9.382e-03 | 1.000e+00 |
DQB1_-10 | A, S | 2 | 9.311e+00 | 9.509e-03 | 1.000e+00 |
DQB1_28 | T, S | 2 | 9.008e+00 | 1.106e-02 | 1.000e+00 |
DQB1_46 | V, E | 2 | 9.008e+00 | 1.106e-02 | 1.000e+00 |
DQB1_47 | Y, F | 2 | 9.008e+00 | 1.106e-02 | 1.000e+00 |
DQB1_52 | P, L | 2 | 9.008e+00 | 1.106e-02 | 1.000e+00 |
DQB1_74 | E, A, S | 3 | 1.094e+01 | 1.206e-02 | 1.000e+00 |
DQA1_-16 | M, L | 2 | 8.506e+00 | 1.422e-02 | 1.000e+00 |
DQB1_75 | L, V | 2 | 8.352e+00 | 1.536e-02 | 1.000e+00 |
B_163 | E, L, T | 3 | 1.031e+01 | 1.610e-02 | 1.000e+00 |
DRB1_-17 | T, A | 2 | 7.971e+00 | 1.859e-02 | 1.000e+00 |
DQB1_71 | T, K, D, A | 4 | 1.182e+01 | 1.874e-02 | 1.000e+00 |
DRB1_13 | R, Y, S, F, H, G | 6 | 1.515e+01 | 1.914e-02 | 1.000e+00 |
DRB1_96 | Q, H, Y, E | 4 | 1.167e+01 | 1.999e-02 | 1.000e+00 |
DQB1_57 | D, A, V, S | 4 | 1.140e+01 | 2.237e-02 | 1.000e+00 |
DQB1_37 | Y, I, D | 3 | 9.592e+00 | 2.237e-02 | 1.000e+00 |
DQA1_129 | H, Q | 2 | 7.539e+00 | 2.306e-02 | 1.000e+00 |
DRB1_14 | E, K | 2 | 7.501e+00 | 2.350e-02 | 1.000e+00 |
DRB1_25 | R, Q | 2 | 7.501e+00 | 2.350e-02 | 1.000e+00 |
DRB1_233 | T, R | 2 | 7.265e+00 | 2.645e-02 | 1.000e+00 |
DQA1_75 | S, I | 2 | 7.203e+00 | 2.729e-02 | 1.000e+00 |
DPB1_85 | G, E | 2 | 7.165e+00 | 2.781e-02 | 1.000e+00 |
DPB1_86 | P, A | 2 | 7.165e+00 | 2.781e-02 | 1.000e+00 |
DPB1_87 | M, V | 2 | 7.165e+00 | 2.781e-02 | 1.000e+00 |
DQA1_107 | I, T | 2 | 6.892e+00 | 3.187e-02 | 1.000e+00 |
DQA1_156 | L, F | 2 | 6.892e+00 | 3.187e-02 | 1.000e+00 |
DQA1_161 | E, D | 2 | 6.892e+00 | 3.187e-02 | 1.000e+00 |
DQA1_163 | S, I | 2 | 6.892e+00 | 3.187e-02 | 1.000e+00 |
DQA1_69 | L, A, T | 3 | 8.813e+00 | 3.189e-02 | 1.000e+00 |
DQB1_126 | Q, H | 2 | 6.885e+00 | 3.199e-02 | 1.000e+00 |
DRB1_11 | P, G, S, V, L | 5 | 1.221e+01 | 3.207e-02 | 1.000e+00 |
DPB1_56 | E, A | 2 | 6.804e+00 | 3.331e-02 | 1.000e+00 |
DRB1_73 | A, G | 2 | 6.484e+00 | 3.909e-02 | 1.000e+00 |
DQA1_56 | ., G, R | 3 | 8.283e+00 | 4.051e-02 | 1.000e+00 |
DQA1_76 | L, M, V | 3 | 8.283e+00 | 4.051e-02 | 1.000e+00 |
B_245 | A | 1 | 4.168e+00 | 4.120e-02 | 1.000e+00 |
B_275 | E | 1 | 4.168e+00 | 4.120e-02 | 1.000e+00 |
B_295 | . | 1 | 4.168e+00 | 4.120e-02 | 1.000e+00 |
B_296 | A | 1 | 4.168e+00 | 4.120e-02 | 1.000e+00 |
B_297 | V | 1 | 4.168e+00 | 4.120e-02 | 1.000e+00 |
B_299 | V | 1 | 4.168e+00 | 4.120e-02 | 1.000e+00 |
B_300 | I | 1 | 4.168e+00 | 4.120e-02 | 1.000e+00 |
B_301 | G | 1 | 4.168e+00 | 4.120e-02 | 1.000e+00 |
B_308 | M | 1 | 4.168e+00 | 4.120e-02 | 1.000e+00 |
B_339 | A | 1 | 4.168e+00 | 4.120e-02 | 1.000e+00 |
B_63 | N, E | 2 | 6.264e+00 | 4.363e-02 | 1.000e+00 |
B_143 | T, S | 2 | 6.242e+00 | 4.412e-02 | 1.000e+00 |
B_147 | W, L | 2 | 6.242e+00 | 4.412e-02 | 1.000e+00 |
DQB1_53 | Q, L | 2 | 6.167e+00 | 4.581e-02 | 1.000e+00 |
DQB1_84 | E, Q | 2 | 6.167e+00 | 4.581e-02 | 1.000e+00 |
DQB1_85 | V, L | 2 | 6.167e+00 | 4.581e-02 | 1.000e+00 |
DQB1_89 | G, T | 2 | 6.167e+00 | 4.581e-02 | 1.000e+00 |
DQB1_90 | I, T | 2 | 6.167e+00 | 4.581e-02 | 1.000e+00 |
DQB1_220 | R, H | 2 | 6.150e+00 | 4.618e-02 | 1.000e+00 |
DQB1_221 | Q, H | 2 | 6.150e+00 | 4.618e-02 | 1.000e+00 |
DRB1_70 | Q, D, R | 3 | 7.952e+00 | 4.701e-02 | 1.000e+00 |
B_178 | K, T | 2 | 6.097e+00 | 4.744e-02 | 1.000e+00 |
DQA1_175 | K, E, Q | 3 | 7.652e+00 | 5.378e-02 | 1.000e+00 |
DRB1_4 | R, Q | 2 | 5.806e+00 | 5.486e-02 | 1.000e+00 |
DRB1_78 | Y, V | 2 | 5.806e+00 | 5.486e-02 | 1.000e+00 |
B_45 | E, K, M, T | 4 | 9.174e+00 | 5.689e-02 | 1.000e+00 |
B_152 | E, V | 2 | 5.717e+00 | 5.736e-02 | 1.000e+00 |
DQB1_-21 | D, G | 2 | 5.706e+00 | 5.767e-02 | 1.000e+00 |
DQB1_-6 | S, T | 2 | 5.706e+00 | 5.767e-02 | 1.000e+00 |
DQB1_-4 | L, V | 2 | 5.706e+00 | 5.767e-02 | 1.000e+00 |
DQB1_203 | V, I | 2 | 5.706e+00 | 5.767e-02 | 1.000e+00 |
A_156 | W, L, Q, R | 4 | 9.095e+00 | 5.876e-02 | 1.000e+00 |
DPB1_84 | G, D | 2 | 5.518e+00 | 6.335e-02 | 1.000e+00 |
DQB1_185 | T, I | 2 | 5.511e+00 | 6.358e-02 | 1.000e+00 |
DQA1_47 | C, K, R, Q | 4 | 8.866e+00 | 6.454e-02 | 1.000e+00 |
B_167 | W, S | 2 | 5.462e+00 | 6.514e-02 | 1.000e+00 |
DPB1_69 | E, K, R | 3 | 7.206e+00 | 6.560e-02 | 1.000e+00 |
DRB1_58 | A, E | 2 | 5.167e+00 | 7.550e-02 | 1.000e+00 |
DRB1_-25 | K, R | 2 | 5.156e+00 | 7.591e-02 | 1.000e+00 |
DRB1_-16 | A, V | 2 | 5.156e+00 | 7.591e-02 | 1.000e+00 |
DQB1_70 | G, R, E | 3 | 6.858e+00 | 7.656e-02 | 1.000e+00 |
DQA1_54 | F, L | 2 | 4.945e+00 | 8.436e-02 | 1.000e+00 |
DQB1_56 | P, L | 2 | 4.874e+00 | 8.743e-02 | 1.000e+00 |
DPA1_111 | K, R | 2 | 4.806e+00 | 9.043e-02 | 1.000e+00 |
DRB1_181 | T, M | 2 | 4.799e+00 | 9.076e-02 | 1.000e+00 |
DQA1_207 | V, M | 2 | 4.785e+00 | 9.142e-02 | 1.000e+00 |
DRB1_74 | A, Q, E, R, L | 5 | 9.459e+00 | 9.208e-02 | 1.000e+00 |
B_116 | Y, L, S, F, D | 5 | 9.438e+00 | 9.281e-02 | 1.000e+00 |
DRB1_77 | T, N | 2 | 4.705e+00 | 9.511e-02 | 1.000e+00 |
DQB1_66 | E, D | 2 | 4.696e+00 | 9.554e-02 | 1.000e+00 |
DQB1_67 | V, I | 2 | 4.696e+00 | 9.554e-02 | 1.000e+00 |
A_186 | K | 1 | 2.777e+00 | 9.565e-02 | 1.000e+00 |
B_-9 | A | 1 | 2.777e+00 | 9.565e-02 | 1.000e+00 |
B_211 | A | 1 | 2.777e+00 | 9.565e-02 | 1.000e+00 |
B_239 | R | 1 | 2.777e+00 | 9.565e-02 | 1.000e+00 |
B_253 | E | 1 | 2.777e+00 | 9.565e-02 | 1.000e+00 |
B_267 | P | 1 | 2.777e+00 | 9.565e-02 | 1.000e+00 |
B_268 | K | 1 | 2.777e+00 | 9.565e-02 | 1.000e+00 |
B_270 | L | 1 | 2.777e+00 | 9.565e-02 | 1.000e+00 |
DQB1_23 | R | 1 | 2.777e+00 | 9.565e-02 | 1.000e+00 |
B_199 | A, V | 2 | 4.597e+00 | 1.004e-01 | 1.000e+00 |
B_46 | E, A | 2 | 4.545e+00 | 1.030e-01 | 1.000e+00 |
DQA1_11 | Y, C | 2 | 4.503e+00 | 1.052e-01 | 1.000e+00 |
DQA1_18 | S, F | 2 | 4.503e+00 | 1.052e-01 | 1.000e+00 |
DQA1_45 | V, A | 2 | 4.503e+00 | 1.052e-01 | 1.000e+00 |
DQA1_48 | L, W | 2 | 4.503e+00 | 1.052e-01 | 1.000e+00 |
DQA1_55 | R, G | 2 | 4.503e+00 | 1.052e-01 | 1.000e+00 |
DQA1_61 | F, G | 2 | 4.503e+00 | 1.052e-01 | 1.000e+00 |
DQA1_64 | T, R | 2 | 4.503e+00 | 1.052e-01 | 1.000e+00 |
DQA1_66 | I, M | 2 | 4.503e+00 | 1.052e-01 | 1.000e+00 |
DQA1_80 | S, Y | 2 | 4.503e+00 | 1.052e-01 | 1.000e+00 |
A_163 | R, T | 2 | 4.467e+00 | 1.072e-01 | 1.000e+00 |
A_90 | D, A | 2 | 4.340e+00 | 1.142e-01 | 1.000e+00 |
DRB1_149 | Q, H | 2 | 4.337e+00 | 1.143e-01 | 1.000e+00 |
DPA1_31 | M, Q | 2 | 4.297e+00 | 1.167e-01 | 1.000e+00 |
DPA1_50 | Q, R | 2 | 4.237e+00 | 1.202e-01 | 1.000e+00 |
DPA1_127 | L, P | 2 | 4.237e+00 | 1.202e-01 | 1.000e+00 |
DPA1_160 | F, V | 2 | 4.237e+00 | 1.202e-01 | 1.000e+00 |
DPA1_228 | T, P | 2 | 4.237e+00 | 1.202e-01 | 1.000e+00 |
DQA1_218 | R, Q | 2 | 4.214e+00 | 1.216e-01 | 1.000e+00 |
B_171 | Y, H | 2 | 4.132e+00 | 1.267e-01 | 1.000e+00 |
DPB1_36 | V, A | 2 | 4.077e+00 | 1.302e-01 | 1.000e+00 |
DRB1_37 | S, F, N, Y, L | 5 | 8.451e+00 | 1.331e-01 | 1.000e+00 |
DQB1_13 | G, A | 2 | 3.986e+00 | 1.363e-01 | 1.000e+00 |
DQB1_167 | R, H | 2 | 3.986e+00 | 1.363e-01 | 1.000e+00 |
DQA1_50 | V, L, E | 3 | 5.421e+00 | 1.435e-01 | 1.000e+00 |
DQA1_53 | Q, R, K | 3 | 5.421e+00 | 1.435e-01 | 1.000e+00 |
DRB1_10 | Q, Y | 2 | 3.868e+00 | 1.446e-01 | 1.000e+00 |
DQA1_52 | R, H, S | 3 | 5.388e+00 | 1.455e-01 | 1.000e+00 |
A_105 | P, S | 2 | 3.819e+00 | 1.482e-01 | 1.000e+00 |
DQB1_86 | A, E, G | 3 | 5.340e+00 | 1.485e-01 | 1.000e+00 |
DPA1_83 | T, A | 2 | 3.592e+00 | 1.660e-01 | 1.000e+00 |
A_77 | S, D, N | 3 | 4.931e+00 | 1.770e-01 | 1.000e+00 |
C_66 | K, N | 2 | 3.422e+00 | 1.807e-01 | 1.000e+00 |
DRB1_60 | Y, S, H | 3 | 4.810e+00 | 1.863e-01 | 1.000e+00 |
DQB1_45 | G, E | 2 | 3.314e+00 | 1.907e-01 | 1.000e+00 |
DRB1_12 | K, T | 2 | 3.314e+00 | 1.907e-01 | 1.000e+00 |
DRB1_30 | Y, L, C, H | 4 | 6.083e+00 | 1.930e-01 | 1.000e+00 |
DPB1_96 | R, K | 2 | 3.268e+00 | 1.951e-01 | 1.000e+00 |
DPB1_170 | T, I | 2 | 3.268e+00 | 1.951e-01 | 1.000e+00 |
DQA1_40 | G, E | 2 | 3.267e+00 | 1.953e-01 | 1.000e+00 |
DQA1_51 | L, F | 2 | 3.267e+00 | 1.953e-01 | 1.000e+00 |
DRB1_180 | V, L | 2 | 3.262e+00 | 1.958e-01 | 1.000e+00 |
C_152 | E, A | 2 | 3.198e+00 | 2.021e-01 | 1.000e+00 |
C_77 | S, N | 2 | 3.197e+00 | 2.022e-01 | 1.000e+00 |
C_80 | N, K | 2 | 3.197e+00 | 2.022e-01 | 1.000e+00 |
DRB1_16 | H, Y | 2 | 3.090e+00 | 2.133e-01 | 1.000e+00 |
C_1 | C, G | 2 | 3.081e+00 | 2.142e-01 | 1.000e+00 |
B_113 | H, Y | 2 | 3.079e+00 | 2.145e-01 | 1.000e+00 |
DRB1_-24 | L, F | 2 | 3.057e+00 | 2.169e-01 | 1.000e+00 |
A_73 | T, I | 2 | 3.047e+00 | 2.180e-01 | 1.000e+00 |
DRB1_28 | D, E | 2 | 3.036e+00 | 2.192e-01 | 1.000e+00 |
DPB1_55 | D, E, A | 3 | 4.338e+00 | 2.272e-01 | 1.000e+00 |
DRB1_33 | N, H | 2 | 2.928e+00 | 2.313e-01 | 1.000e+00 |
DRB1_140 | A, T | 2 | 2.904e+00 | 2.341e-01 | 1.000e+00 |
DQA1_41 | R, K | 2 | 2.893e+00 | 2.354e-01 | 1.000e+00 |
DQA1_130 | S, A | 2 | 2.893e+00 | 2.354e-01 | 1.000e+00 |
A_43 | Q | 1 | 1.387e+00 | 2.389e-01 | 1.000e+00 |
A_219 | R | 1 | 1.387e+00 | 2.389e-01 | 1.000e+00 |
A_231 | V | 1 | 1.387e+00 | 2.389e-01 | 1.000e+00 |
B_109 | L | 1 | 1.387e+00 | 2.389e-01 | 1.000e+00 |
C_175 | G | 1 | 1.387e+00 | 2.389e-01 | 1.000e+00 |
C_173 | E, K | 2 | 2.722e+00 | 2.564e-01 | 1.000e+00 |
DQB1_-27 | A, S | 2 | 2.715e+00 | 2.574e-01 | 1.000e+00 |
DQB1_-9 | M, I | 2 | 2.715e+00 | 2.574e-01 | 1.000e+00 |
DQB1_224 | Q, R | 2 | 2.715e+00 | 2.574e-01 | 1.000e+00 |
C_103 | L, V | 2 | 2.700e+00 | 2.592e-01 | 1.000e+00 |
C_91 | G, R | 2 | 2.649e+00 | 2.659e-01 | 1.000e+00 |
B_-16 | V, L | 2 | 2.571e+00 | 2.765e-01 | 1.000e+00 |
B_194 | I, V | 2 | 2.556e+00 | 2.785e-01 | 1.000e+00 |
DRB1_57 | D, V, A, S | 4 | 5.068e+00 | 2.804e-01 | 1.000e+00 |
DQA1_26 | T, S | 2 | 2.541e+00 | 2.807e-01 | 1.000e+00 |
DQA1_187 | A, T | 2 | 2.541e+00 | 2.807e-01 | 1.000e+00 |
DRB1_189 | R, S | 2 | 2.532e+00 | 2.820e-01 | 1.000e+00 |
DQA1_-7 | V, M | 1 | 1.142e+00 | 2.852e-01 | 1.000e+00 |
DQA1_2 | G | 1 | 1.142e+00 | 2.852e-01 | 1.000e+00 |
DRB1_32 | Y, H | 2 | 2.498e+00 | 2.868e-01 | 1.000e+00 |
B_94 | T, I | 2 | 2.473e+00 | 2.904e-01 | 1.000e+00 |
C_24 | A, S | 2 | 2.431e+00 | 2.966e-01 | 1.000e+00 |
A_-22 | V | 1 | 1.051e+00 | 3.054e-01 | 1.000e+00 |
A_-21 | M | 1 | 1.051e+00 | 3.054e-01 | 1.000e+00 |
A_-18 | R | 1 | 1.051e+00 | 3.054e-01 | 1.000e+00 |
A_-16 | L | 1 | 1.051e+00 | 3.054e-01 | 1.000e+00 |
A_-5 | T | 1 | 1.051e+00 | 3.054e-01 | 1.000e+00 |
A_-2 | W | 1 | 1.051e+00 | 3.054e-01 | 1.000e+00 |
A_284 | I | 1 | 1.051e+00 | 3.054e-01 | 1.000e+00 |
A_288 | I | 1 | 1.051e+00 | 3.054e-01 | 1.000e+00 |
DRB1_120 | S, N | 2 | 2.317e+00 | 3.140e-01 | 1.000e+00 |
DRB1_47 | F, Y | 2 | 2.287e+00 | 3.187e-01 | 1.000e+00 |
DPB1_205 | V, M | 2 | 2.274e+00 | 3.208e-01 | 1.000e+00 |
A_9 | Y, F, S, T | 4 | 4.680e+00 | 3.218e-01 | 1.000e+00 |
C_193 | P, L | 2 | 2.256e+00 | 3.237e-01 | 1.000e+00 |
DQB1_14 | M, L | 2 | 2.236e+00 | 3.270e-01 | 1.000e+00 |
DQB1_116 | V, I | 2 | 2.236e+00 | 3.270e-01 | 1.000e+00 |
A_283 | P, H | 2 | 2.214e+00 | 3.306e-01 | 1.000e+00 |
B_12 | V, M | 2 | 2.186e+00 | 3.352e-01 | 1.000e+00 |
C_309 | V, M | 2 | 2.171e+00 | 3.377e-01 | 1.000e+00 |
DRB1_67 | I, L, F | 3 | 3.360e+00 | 3.394e-01 | 1.000e+00 |
B_11 | S, A | 2 | 2.145e+00 | 3.421e-01 | 1.000e+00 |
DPB1_11 | G, L | 2 | 2.127e+00 | 3.452e-01 | 1.000e+00 |
C_113 | Y, H | 2 | 2.014e+00 | 3.653e-01 | 1.000e+00 |
A_109 | L | 1 | 8.077e-01 | 3.688e-01 | 1.000e+00 |
B_145 | R, L | 2 | 1.976e+00 | 3.723e-01 | 1.000e+00 |
DPB1_8 | L, V | 2 | 1.958e+00 | 3.758e-01 | 1.000e+00 |
A_297 | V, M | 2 | 1.889e+00 | 3.889e-01 | 1.000e+00 |
DQA1_199 | T | 1 | 7.318e-01 | 3.923e-01 | 1.000e+00 |
C_14 | R, W | 2 | 1.834e+00 | 3.998e-01 | 1.000e+00 |
C_49 | A, E | 2 | 1.834e+00 | 3.998e-01 | 1.000e+00 |
A_76 | E, V, A | 3 | 2.935e+00 | 4.018e-01 | 1.000e+00 |
B_32 | Q, L | 2 | 1.766e+00 | 4.136e-01 | 1.000e+00 |
C_-17 | T, A | 2 | 1.725e+00 | 4.221e-01 | 1.000e+00 |
A_144 | Q, K | 2 | 1.719e+00 | 4.234e-01 | 1.000e+00 |
B_-23 | L, R | 2 | 1.687e+00 | 4.302e-01 | 1.000e+00 |
DQA1_-13 | T, A | 2 | 1.635e+00 | 4.414e-01 | 1.000e+00 |
C_114 | D, N | 2 | 1.576e+00 | 4.547e-01 | 1.000e+00 |
C_-9 | A, G | 2 | 1.573e+00 | 4.555e-01 | 1.000e+00 |
DPB1_76 | M, V, I | 3 | 2.568e+00 | 4.631e-01 | 1.000e+00 |
A_246 | S, A | 2 | 1.532e+00 | 4.648e-01 | 1.000e+00 |
C_219 | R, W | 2 | 1.528e+00 | 4.657e-01 | 1.000e+00 |
C_147 | W, L | 2 | 1.511e+00 | 4.697e-01 | 1.000e+00 |
C_35 | R, Q | 2 | 1.502e+00 | 4.718e-01 | 1.000e+00 |
DRB1_9 | W, E | 2 | 1.495e+00 | 4.735e-01 | 1.000e+00 |
DPB1_-14 | T | 1 | 5.094e-01 | 4.754e-01 | 1.000e+00 |
DQA1_160 | A, D | 2 | 1.482e+00 | 4.767e-01 | 1.000e+00 |
DPB1_33 | Q | 1 | 4.988e-01 | 4.800e-01 | 1.000e+00 |
A_299 | A, T | 2 | 1.466e+00 | 4.805e-01 | 1.000e+00 |
A_334 | M, V | 2 | 1.466e+00 | 4.805e-01 | 1.000e+00 |
DRB1_86 | V, G | 2 | 1.448e+00 | 4.847e-01 | 1.000e+00 |
C_21 | R, H | 2 | 1.394e+00 | 4.980e-01 | 1.000e+00 |
C_73 | A, T | 2 | 1.376e+00 | 5.027e-01 | 1.000e+00 |
C_332 | S, C | 2 | 1.339e+00 | 5.120e-01 | 1.000e+00 |
B_-21 | M, T | 2 | 1.330e+00 | 5.144e-01 | 1.000e+00 |
C_253 | E, Q | 2 | 1.321e+00 | 5.166e-01 | 1.000e+00 |
C_267 | P, Q | 2 | 1.321e+00 | 5.166e-01 | 1.000e+00 |
C_312 | V, A | 2 | 1.321e+00 | 5.166e-01 | 1.000e+00 |
C_163 | T, L, E | 3 | 2.260e+00 | 5.203e-01 | 1.000e+00 |
DPA1_11 | A, M | 2 | 1.299e+00 | 5.224e-01 | 1.000e+00 |
A_149 | T, A | 2 | 1.254e+00 | 5.343e-01 | 1.000e+00 |
C_194 | V, L | 2 | 1.236e+00 | 5.391e-01 | 1.000e+00 |
C_261 | V, M | 2 | 1.236e+00 | 5.391e-01 | 1.000e+00 |
C_273 | R, S | 2 | 1.236e+00 | 5.391e-01 | 1.000e+00 |
C_295 | A, V | 2 | 1.236e+00 | 5.391e-01 | 1.000e+00 |
C_311 | A, T | 2 | 1.236e+00 | 5.391e-01 | 1.000e+00 |
C_313 | V, M | 2 | 1.236e+00 | 5.391e-01 | 1.000e+00 |
C_345 | A, T | 2 | 1.236e+00 | 5.391e-01 | 1.000e+00 |
A_56 | G, R | 2 | 1.228e+00 | 5.411e-01 | 1.000e+00 |
B_41 | A, T | 2 | 1.228e+00 | 5.412e-01 | 1.000e+00 |
A_161 | E, D | 2 | 1.204e+00 | 5.478e-01 | 1.000e+00 |
A_276 | P, L | 2 | 1.198e+00 | 5.493e-01 | 1.000e+00 |
A_321 | S, T | 2 | 1.198e+00 | 5.493e-01 | 1.000e+00 |
DPB1_9 | F, Y, H | 3 | 2.109e+00 | 5.501e-01 | 1.000e+00 |
DQB1_-17 | A, P | 2 | 1.187e+00 | 5.525e-01 | 1.000e+00 |
DQB1_3 | S, P | 2 | 1.187e+00 | 5.525e-01 | 1.000e+00 |
DQB1_197 | S, N | 2 | 1.187e+00 | 5.525e-01 | 1.000e+00 |
C_138 | T, K | 2 | 1.169e+00 | 5.573e-01 | 1.000e+00 |
C_-18 | R | 1 | 3.408e-01 | 5.594e-01 | 1.000e+00 |
C_-5 | T | 1 | 3.408e-01 | 5.594e-01 | 1.000e+00 |
C_-1 | A | 1 | 3.408e-01 | 5.594e-01 | 1.000e+00 |
C_186 | K | 1 | 3.408e-01 | 5.594e-01 | 1.000e+00 |
C_270 | L | 1 | 3.408e-01 | 5.594e-01 | 1.000e+00 |
C_284 | I | 1 | 3.408e-01 | 5.594e-01 | 1.000e+00 |
C_289 | A | 1 | 3.408e-01 | 5.594e-01 | 1.000e+00 |
C_291 | L | 1 | 3.408e-01 | 5.594e-01 | 1.000e+00 |
C_314 | M | 1 | 3.408e-01 | 5.594e-01 | 1.000e+00 |
C_315 | C | 1 | 3.408e-01 | 5.594e-01 | 1.000e+00 |
C_327 | C | 1 | 3.408e-01 | 5.594e-01 | 1.000e+00 |
C_330 | A | 1 | 3.408e-01 | 5.594e-01 | 1.000e+00 |
DPB1_215 | I | 1 | 3.408e-01 | 5.594e-01 | 1.000e+00 |
A_151 | H, R | 2 | 1.161e+00 | 5.597e-01 | 1.000e+00 |
C_184 | H, P | 2 | 1.093e+00 | 5.789e-01 | 1.000e+00 |
C_285 | V, M | 2 | 1.093e+00 | 5.789e-01 | 1.000e+00 |
DQB1_227 | ., P | 2 | 1.091e+00 | 5.796e-01 | 1.000e+00 |
DQB1_228 | ., Q | 2 | 1.091e+00 | 5.796e-01 | 1.000e+00 |
DQB1_229 | ., G | 2 | 1.091e+00 | 5.796e-01 | 1.000e+00 |
DQB1_230 | ., P | 2 | 1.091e+00 | 5.796e-01 | 1.000e+00 |
DQB1_231 | ., P | 2 | 1.091e+00 | 5.796e-01 | 1.000e+00 |
DQB1_232 | ., P | 2 | 1.091e+00 | 5.796e-01 | 1.000e+00 |
DQB1_233 | ., A | 2 | 1.091e+00 | 5.796e-01 | 1.000e+00 |
DQB1_234 | ., G | 2 | 1.091e+00 | 5.796e-01 | 1.000e+00 |
B_131 | R, S | 2 | 1.054e+00 | 5.902e-01 | 1.000e+00 |
A_245 | A, V | 2 | 1.052e+00 | 5.909e-01 | 1.000e+00 |
A_107 | G, W | 2 | 1.047e+00 | 5.926e-01 | 1.000e+00 |
C_94 | T, I | 2 | 1.044e+00 | 5.935e-01 | 1.000e+00 |
A_63 | N, E, Q | 3 | 1.882e+00 | 5.973e-01 | 1.000e+00 |
DRB1_26 | F, Y, L | 3 | 1.844e+00 | 6.054e-01 | 1.000e+00 |
A_74 | D, H | 2 | 1.002e+00 | 6.059e-01 | 1.000e+00 |
C_275 | E, K, G | 3 | 1.833e+00 | 6.078e-01 | 1.000e+00 |
C_90 | A, D | 2 | 9.661e-01 | 6.169e-01 | 1.000e+00 |
C_95 | L, I | 2 | 9.617e-01 | 6.183e-01 | 1.000e+00 |
C_11 | A, S | 2 | 9.525e-01 | 6.211e-01 | 1.000e+00 |
DQB1_140 | A, T | 2 | 9.334e-01 | 6.271e-01 | 1.000e+00 |
DQB1_182 | S, N | 2 | 9.334e-01 | 6.271e-01 | 1.000e+00 |
B_158 | A, T | 2 | 9.012e-01 | 6.372e-01 | 1.000e+00 |
B_-8 | L, V | 2 | 8.907e-01 | 6.406e-01 | 1.000e+00 |
B_114 | D, N, H | 3 | 1.682e+00 | 6.410e-01 | 1.000e+00 |
C_156 | W, R, L, Q | 4 | 2.473e+00 | 6.495e-01 | 1.000e+00 |
A_66 | N, K | 2 | 8.571e-01 | 6.515e-01 | 1.000e+00 |
A_142 | I, T | 2 | 8.559e-01 | 6.519e-01 | 1.000e+00 |
A_145 | R, H | 2 | 8.559e-01 | 6.519e-01 | 1.000e+00 |
A_79 | R, G | 2 | 8.418e-01 | 6.565e-01 | 1.000e+00 |
A_80 | I, T | 2 | 8.418e-01 | 6.565e-01 | 1.000e+00 |
A_81 | A, L | 2 | 8.418e-01 | 6.565e-01 | 1.000e+00 |
A_82 | L, R | 2 | 8.418e-01 | 6.565e-01 | 1.000e+00 |
A_83 | R, G | 2 | 8.418e-01 | 6.565e-01 | 1.000e+00 |
A_99 | Y, F | 2 | 8.308e-01 | 6.601e-01 | 1.000e+00 |
C_-15 | I, L | 2 | 8.302e-01 | 6.603e-01 | 1.000e+00 |
B_177 | D, E | 2 | 8.213e-01 | 6.632e-01 | 1.000e+00 |
B_180 | E, Q | 2 | 8.213e-01 | 6.632e-01 | 1.000e+00 |
B_24 | S, T, A | 3 | 1.536e+00 | 6.740e-01 | 1.000e+00 |
DRB1_31 | F, I | 2 | 7.443e-01 | 6.893e-01 | 1.000e+00 |
B_156 | R, L, W, D | 4 | 2.250e+00 | 6.899e-01 | 1.000e+00 |
A_282 | I, V | 2 | 7.338e-01 | 6.929e-01 | 1.000e+00 |
A_311 | K, N | 2 | 7.338e-01 | 6.929e-01 | 1.000e+00 |
DPB1_178 | L, M | 2 | 7.240e-01 | 6.963e-01 | 1.000e+00 |
A_65 | R, G | 2 | 6.831e-01 | 7.107e-01 | 1.000e+00 |
DPB1_57 | E, D | 2 | 6.767e-01 | 7.129e-01 | 1.000e+00 |
A_95 | I, V, L | 3 | 1.360e+00 | 7.148e-01 | 1.000e+00 |
A_127 | N, K | 2 | 6.643e-01 | 7.174e-01 | 1.000e+00 |
C_177 | E, K | 2 | 6.392e-01 | 7.264e-01 | 1.000e+00 |
C_97 | W, R | 2 | 6.277e-01 | 7.306e-01 | 1.000e+00 |
A_44 | R, K | 2 | 6.239e-01 | 7.320e-01 | 1.000e+00 |
A_67 | V, M | 2 | 6.239e-01 | 7.320e-01 | 1.000e+00 |
A_150 | A, V | 2 | 6.239e-01 | 7.320e-01 | 1.000e+00 |
A_158 | A, V | 2 | 6.239e-01 | 7.320e-01 | 1.000e+00 |
DRB1_85 | V, A | 2 | 4.685e-01 | 7.912e-01 | 1.000e+00 |
A_70 | H, Q | 2 | 4.549e-01 | 7.965e-01 | 1.000e+00 |
DQA1_25 | Y, F | 2 | 4.525e-01 | 7.975e-01 | 1.000e+00 |
B_95 | L, W, I | 3 | 9.848e-01 | 8.049e-01 | 1.000e+00 |
DQB1_130 | R, Q | 2 | 4.226e-01 | 8.095e-01 | 1.000e+00 |
C_310 | M, V | 2 | 4.225e-01 | 8.096e-01 | 1.000e+00 |
A_116 | D, Y, H | 3 | 8.461e-01 | 8.384e-01 | 1.000e+00 |
DPB1_65 | I, L | 2 | 3.524e-01 | 8.385e-01 | 1.000e+00 |
DPB1_35 | F, L, Y | 3 | 8.446e-01 | 8.388e-01 | 1.000e+00 |
C_6 | R, K | 2 | 3.499e-01 | 8.395e-01 | 1.000e+00 |
A_17 | R, S | 2 | 3.409e-01 | 8.433e-01 | 1.000e+00 |
A_62 | R, G, E, Q, L | 5 | 2.026e+00 | 8.456e-01 | 1.000e+00 |
C_9 | Y, D, F, S | 4 | 1.236e+00 | 8.722e-01 | 1.000e+00 |
DPB1_194 | R, Q | 2 | 2.279e-01 | 8.923e-01 | 1.000e+00 |
DQB1_26 | L, Y, G | 3 | 6.006e-01 | 8.963e-01 | 1.000e+00 |
A_294 | F, L | 2 | 2.100e-01 | 9.003e-01 | 1.000e+00 |
C_211 | A, T | 2 | 2.036e-01 | 9.032e-01 | 1.000e+00 |
A_184 | A, P | 2 | 1.853e-01 | 9.115e-01 | 1.000e+00 |
DQA1_34 | Q, E | 2 | 1.851e-01 | 9.116e-01 | 1.000e+00 |
A_152 | E, V, A, R | 4 | 9.529e-01 | 9.169e-01 | 1.000e+00 |
A_-15 | V, L | 2 | 1.668e-01 | 9.200e-01 | 1.000e+00 |
B_74 | D, Y | 2 | 1.542e-01 | 9.258e-01 | 1.000e+00 |
B_-10 | A, G | 2 | 1.507e-01 | 9.274e-01 | 1.000e+00 |
A_193 | A, P | 2 | 1.472e-01 | 9.291e-01 | 1.000e+00 |
A_194 | V, I | 2 | 1.472e-01 | 9.291e-01 | 1.000e+00 |
A_207 | S, G | 2 | 1.472e-01 | 9.291e-01 | 1.000e+00 |
A_253 | Q, E | 2 | 1.472e-01 | 9.291e-01 | 1.000e+00 |
C_116 | S, F, Y, L | 4 | 7.424e-01 | 9.460e-01 | 1.000e+00 |
DRB1_98 | K, E | 2 | 1.057e-01 | 9.485e-01 | 1.000e+00 |
DRB1_104 | S, A | 2 | 1.057e-01 | 9.485e-01 | 1.000e+00 |
C_16 | G, S | 2 | 1.028e-01 | 9.499e-01 | 1.000e+00 |
A_298 | I, F | 2 | 8.113e-02 | 9.602e-01 | 1.000e+00 |
A_307 | M, R | 2 | 8.113e-02 | 9.602e-01 | 1.000e+00 |
DQA1_215 | F, L | 2 | 5.353e-02 | 9.736e-01 | 1.000e+00 |
A_97 | R, M, I | 3 | 2.072e-01 | 9.764e-01 | 1.000e+00 |
A_166 | E, D | 2 | 2.644e-02 | 9.869e-01 | 1.000e+00 |
A_167 | W, G | 2 | 2.644e-02 | 9.869e-01 | 1.000e+00 |
A_-11 | S, L | 2 | 2.558e-02 | 9.873e-01 | 1.000e+00 |
A_114 | Q, H, R, E | 4 | 2.952e-01 | 9.901e-01 | 1.000e+00 |
C_248 | V, M | 2 | 1.113e-02 | 9.944e-01 | 1.000e+00 |
B_-11 | S, W | 2 | 7.986e-03 | 9.960e-01 | 1.000e+00 |
DQA1_-6 | M | 1 | 0.000e+00 | 1.000e+00 | 1.000e+00 |
DRB1_38 | V, L | 2 | 0.000e+00 | 1.000e+00 | 1.000e+00 |
Next, we can investigate how effect estimates are distributed for a given associated amino acid position, e.g. DQB1_9:
HLA_AA_DQB1_9_results <- runMiDAS(
HLA_AA_model,
experiment = "hla_aa",
inheritance_model = "dominant",
omnibus_groups_filter = "DQB1_9",
lower_frequency_cutoff = 0.02,
upper_frequency_cutoff = 0.98,
correction = "bonferroni",
exponentiate = TRUE
)
kableResults(HLA_AA_DQB1_9_results, scroll_box_height = "250px")
aa | p.value | p.adjusted | estimate | std.error | conf.low | conf.high | statistic | Ntotal | Ntotal [%] | N(disease=0) | N(disease=0) [%] | N(disease=1) | N(disease=1) [%] |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DQB1_9_F | 7.000e-07 | 2.000e-06 | 2.0572 | 0.1451 | 1.5509 | 2.740 | 4.9729 | 277 | 13.85% | 103 | 10.30% | 174 | 17.40% |
DQB1_9_Y | 1.780e-01 | 5.339e-01 | 0.6259 | 0.3479 | 0.3095 | 1.225 | -1.3470 | 964 | 48.20% | 486 | 48.60% | 478 | 47.80% |
DQB1_9_L | 4.558e-01 | 1.000e+00 | 1.2512 | 0.3005 | 0.6956 | 2.276 | 0.7457 | 47 | 2.35% | 21 | 2.10% | 26 | 2.60% |
This shows us that individuals carrying a Phenylalanine (F) at position 9 of DQB1 have a significantly increased risk, whereas individuals carrying a Tyrosine (Y) at the same amino acid position have a decreased risk.
It is logical to hypothesize that the risk residue is found on HLA-DQB1*06:02, the previously associated HLA risk allele. MiDAS thus provides the function getAllelesforAA
to map amino acid residues back to the respective HLA alleles.
HLA-DQB1 (9) | HLA-DQB1 alleles | count | frequency |
---|---|---|---|
F | 04:01, 04:02, 04:23, 06:02 | 302 | 15.10% |
L | *06:01 | 49 | 2.45% |
Y | 02:01, 02:02, 02:10, 03:01, 03:02, 03:03, 03:04, 03:05, 03:19, 03:22, 03:251, 03:96, 05:01, 05:02, 05:03, 05:04, 05:107, 06:03, 06:04, 06:07, *06:09 | 1649 | 82.45% |
Finally, it is also interesting to note that there are several amino acid positions coming up that determine the Bw4 binding motif (e.g. B_81), which is a determinant for interactions of HLA class I alleles with KIR on Natural Killer cells.
Now that we have performed KIR genotyping, or e.g. inferred KIR types from available whole-genome sequencing data, we can import this information, and check the gene frequencies. In our example, we could successfully infer KIR gene presence status for 935 out of the 1,000 individuals in our data set.
ID | KIR3DL3 | KIR2DS2 | KIR2DL2 | KIR2DL3 | KIR2DP1 | KIR2DL1 | KIR3DP1 | KIR2DL4 | KIR3DL1 | KIR3DS1 | KIR2DL5 | KIR2DS3 | KIR2DS5 | KIR2DS4 | KIR2DS1 | KIR3DL2 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
C001 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C002 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C003 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
C004 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
C005 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C006 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C007 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C008 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C009 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
C010 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
C011 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
C012 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
C013 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
C014 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
C015 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
C016 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
C017 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
C018 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
C019 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
C020 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
C021 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
C022 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
C023 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
C024 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
C025 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
C026 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
C027 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
C028 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
C029 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
C030 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
C031 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
C032 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C033 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C034 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C035 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C036 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C037 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
C038 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C039 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
C040 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C041 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C042 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C043 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C044 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C045 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C046 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C047 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
C048 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
C049 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
C050 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
C051 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
C052 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
C053 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
C054 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
C055 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
C056 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
C057 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
C058 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
C059 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
C060 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
C061 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
C062 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
C063 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
C064 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
C065 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
C066 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
C067 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C068 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C069 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C070 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C071 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
C072 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
C073 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C074 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C075 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C076 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
C077 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C078 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
C079 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C080 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C081 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C082 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C083 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C084 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C085 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C086 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
C087 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C088 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
C089 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
C090 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C091 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C092 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C093 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C094 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C095 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C096 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C097 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
C098 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C099 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C100 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
C101 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
C102 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C103 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C104 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C105 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C106 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C107 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
C108 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C109 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C110 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C111 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C112 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
C113 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C114 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
C115 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C116 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C117 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C118 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
C119 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C120 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
C121 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C122 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C123 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C124 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C125 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C126 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C127 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C128 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C129 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C130 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C131 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C132 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C133 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C134 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
C135 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
C136 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C137 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
C138 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C139 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C140 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C141 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C142 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C143 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C144 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C145 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
C146 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
C147 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C148 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C149 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C150 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C151 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
C152 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C153 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C154 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C155 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C156 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C157 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C158 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C159 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C160 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
C161 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C162 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C163 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C164 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
C165 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C166 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C167 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C168 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
C169 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C170 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C171 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
C172 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C173 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C174 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
C175 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C176 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C177 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C178 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
C179 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C180 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C181 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C182 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C183 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
C184 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C185 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C186 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C187 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C188 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C189 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C190 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C191 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C192 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
C193 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C194 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
C195 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C196 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
C197 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
C198 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
C199 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C200 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
C201 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
C202 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C203 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
C204 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C205 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C206 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 |
C207 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C208 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C209 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
C210 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C211 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
C212 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C213 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 |
C214 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C215 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
C216 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C217 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
C218 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C219 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C220 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C221 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C222 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C223 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C224 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C225 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C226 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C227 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C228 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C229 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
C230 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C231 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C232 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C233 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C234 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C235 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
C236 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C237 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C238 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C239 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C240 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C241 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C242 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C243 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C244 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C245 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C246 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C247 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C248 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
C249 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C250 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C251 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C252 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C253 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C254 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C255 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
C256 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
C257 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C258 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C259 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C260 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
C261 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C262 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
C263 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C264 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C265 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C266 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
C267 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C268 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
C269 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C270 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C271 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C272 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
C273 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C274 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C275 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
C276 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C277 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C278 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C279 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C280 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C281 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C282 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C283 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C284 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
C285 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C286 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C287 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
C288 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
C289 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
C290 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C291 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C292 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C293 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
C294 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C295 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C296 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
C297 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C298 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
C299 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C300 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C301 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C302 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
C303 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
C304 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C305 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C306 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
C307 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C308 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C309 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C310 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C311 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C312 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C313 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C314 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C315 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C316 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
C317 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C318 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C319 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C320 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C321 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C322 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
C323 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C324 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C325 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C326 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C327 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 |
C328 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C329 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C330 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C331 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
C332 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C333 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C334 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
C335 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C336 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C337 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C338 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C339 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
C340 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C341 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C342 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
C343 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C344 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C345 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
C346 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
C347 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C348 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C349 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C350 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C351 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
C352 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C353 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C354 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C355 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C356 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C357 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C358 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C359 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
C360 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
C361 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C362 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C363 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
C364 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
C365 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C366 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C367 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
C368 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
C369 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C370 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C371 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C372 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C373 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C374 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C375 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C376 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C377 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
C378 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C379 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C380 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C381 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C382 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C383 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
C384 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C385 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C386 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C387 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
C388 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
C389 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C390 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C391 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
C392 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
C393 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C394 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C395 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C396 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C397 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C398 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
C399 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C400 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C401 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C402 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C403 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C404 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C405 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C406 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
C407 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C408 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C409 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C410 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C411 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
C412 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
C413 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C414 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
C415 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C416 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C417 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C418 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C419 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C420 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C421 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C422 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
C423 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C424 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C425 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C426 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C427 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C428 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C429 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C430 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C431 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C432 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
C433 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C434 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
C435 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C436 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
C437 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
C438 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
C439 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C440 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C441 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C442 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C443 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C444 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C445 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
C446 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C447 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C448 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C449 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
C450 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
C451 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C452 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C453 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C454 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
C455 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C456 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C457 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 |
C458 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C459 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C460 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C461 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
C462 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C463 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C464 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C465 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C466 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C467 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C468 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C469 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C470 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C471 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
C472 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C473 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C474 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C475 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C476 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C477 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C478 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C479 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C480 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
C481 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C482 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
C483 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C484 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C485 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C486 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C487 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
C488 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C489 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C490 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C491 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
C492 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C493 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C494 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
C495 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C496 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C497 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
C498 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C499 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
C500 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
P001 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P002 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P003 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P004 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P005 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
P006 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P007 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P008 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
P009 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P010 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P011 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P012 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
P013 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P014 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P015 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P016 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P017 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P018 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
P019 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P020 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
P021 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P022 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P023 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
P024 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P025 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P026 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P027 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P028 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P029 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P030 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P031 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
P032 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
P033 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
P034 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P035 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P036 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
P037 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P038 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P039 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P040 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P041 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
P042 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P043 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P044 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P045 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
P046 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P047 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P048 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
P049 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P050 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P051 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P052 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P053 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P054 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P055 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
P056 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P057 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
P058 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
P059 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
P060 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P061 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P062 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
P063 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P064 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
P065 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P066 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P067 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P068 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P069 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P070 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P071 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
P072 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P073 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P074 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P075 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P076 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
P077 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P078 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
P079 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P080 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
P081 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P082 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
P083 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P084 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
P085 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
P086 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
P087 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
P088 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P089 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P090 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P091 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P092 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P093 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P094 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P095 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 |
P096 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P097 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P098 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P099 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
P100 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P101 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P102 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P103 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
P104 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P105 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P106 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P107 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
P108 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P109 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
P110 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P111 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P112 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
P113 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P114 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
P115 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P116 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
P117 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
P118 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P119 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P120 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P121 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P122 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P123 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P124 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P125 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P126 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P127 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P128 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P129 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P130 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P131 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P132 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
P133 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
P134 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P135 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P136 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
P137 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P138 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
P139 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P140 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P141 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P142 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P143 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P144 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P145 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P146 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P147 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P148 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P149 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P150 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P151 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P152 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
P153 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P154 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P155 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P156 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P157 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P158 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P159 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P160 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P161 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P162 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P163 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P164 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
P165 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P166 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
P167 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
P168 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
P169 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
P170 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P171 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P172 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P173 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
P174 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P175 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P176 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P177 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P178 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
P179 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P180 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P181 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
P182 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P183 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P184 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P185 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P186 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P187 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P188 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P189 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
P190 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
P191 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
P192 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P193 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
P194 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P195 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P196 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P197 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P198 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P199 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P200 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P201 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P202 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P203 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 |
P204 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P205 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 |
P206 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
P207 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P208 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P209 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P210 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P211 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P212 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P213 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P214 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P215 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P216 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
P217 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P218 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P219 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P220 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P221 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
P222 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P223 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P224 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 |
P225 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P226 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P227 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
P228 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P229 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P230 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P231 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
P232 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P233 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P234 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P235 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P236 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P237 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
P238 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P239 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P240 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P241 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P242 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P243 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P244 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P245 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P246 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
P247 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
P248 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P249 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
P250 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
P251 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 |
P252 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P253 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
P254 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P255 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P256 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 |
P257 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
P258 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
P259 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P260 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P261 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P262 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
P263 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P264 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
P265 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
P266 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
P267 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P268 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
P269 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
P270 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P271 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P272 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
P273 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
P274 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
P275 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
P276 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P277 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
P278 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P279 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 |
P280 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P281 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P282 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
P283 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P284 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
P285 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
P286 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P287 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P288 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P289 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
P290 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P291 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P292 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P293 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
P294 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
P295 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P296 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P297 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P298 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P299 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P300 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P301 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P302 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P303 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
P304 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 |
P305 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P306 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P307 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P308 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P309 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P310 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P311 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P312 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P313 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P314 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P315 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P316 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
P317 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
P318 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
P319 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
P320 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P321 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
P322 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P323 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
P324 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P325 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
P326 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P327 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P328 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P329 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
P330 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P331 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P332 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P333 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P334 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
P335 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P336 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P337 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
P338 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
P339 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
P340 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P341 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P342 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P343 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P344 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P345 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P346 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P347 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P348 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
P349 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P350 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P351 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P352 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P353 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P354 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P355 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P356 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P357 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P358 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P359 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
P360 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P361 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P362 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P363 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P364 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P365 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P366 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
P367 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P368 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
P369 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P370 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P371 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P372 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P373 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P374 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P375 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P376 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P377 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P378 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
P379 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
P380 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P381 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P382 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P383 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P384 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P385 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P386 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P387 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P388 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
P389 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P390 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
P391 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P392 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P393 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P394 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P395 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P396 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P397 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
P398 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
P399 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P400 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P401 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P402 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P403 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P404 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
P405 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P406 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P407 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P408 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
P409 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P410 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P411 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
P412 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P413 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
P414 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P415 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P416 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P417 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P418 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 |
P419 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P420 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P421 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
P422 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P423 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P424 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P425 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
P426 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
P427 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P428 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P429 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P430 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P431 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P432 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P433 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P434 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
P435 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 |
P436 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
P437 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
P438 | 1 | 0 | 0 | 1 |