synergyfinder

DOI: 10.18129/B9.bioc.synergyfinder    

This package is for version 3.12 of Bioconductor; for the stable, up-to-date release version, see synergyfinder.

Calculate and Visualize Synergy Scores for Drug Combinations

Bioconductor version: 3.12

Efficient implementations for analyzing pre-clinical multiple drug combination datasets. 1. Synergy scores valuculation via all the popular models, including HSA, Loewe, Bliss and ZIP; 2. Drug Sensitivity Score (CSS) and Relitave Inhibition (RI) for drug sensitivity evaluation; 3. Visualization for drug combination matrices and scores. Based on this package, we also provide a web application (http://synergyfinder.org/) for users who prefer more friendly user interface.

Author: Shuyu Zheng [aut, cre], Jing Tang [aut]

Maintainer: Shuyu Zheng <shuyu.zheng at helsinki.fi>

Installation

To install this package, start R (version "4.0") and enter:

if (!requireNamespace("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("synergyfinder")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

PDF		Reference Manual
Text		NEWS

Details

biocViews	Software, StatisticalMethod
Version	2.4.16
In Bioconductor since	BioC 3.4 (R-3.3) (4.5 years)
License	Mozilla Public License 2.0
Depends	R (>= 4.0.0), drc (>= 3.0-1), reshape2 (>= 1.4.4), tidyverse (>= 1.3.0), dplyr (>= 1.0.3), tidyr (>= 1.1.2), purrr (>= 0.3.4), furrr (>= 0.2.2), ggplot2 (>= 3.3.3), ggforce (>= 0.3.2), grid (>= 4.0.2), vegan (>= 2.5-7), gstat (>= 2.0-6), sp (>= 1.4-5), methods (>= 4.0.2), SpatialExtremes (>= 2.0-9), ggrepel (>= 0.9.1), kriging (>= 1.1), plotly (>= 4.9.3), stringr (>= 1.4.0), future (>= 1.21.0), mice (>= 3.13.0), lattice (>= 0.20-41), nleqslv (>= 3.3.2), stats (>= 4.0.2), graphics (>= 4.0.2), grDevices (>= 4.0.2), magrittr (>= 2.0.1), pbapply (>= 1.4-3), metR (>= 0.9.1)
Imports	drc (>= 3.0-1), reshape2 (>= 1.4.4), tidyverse (>= 1.3.0), dplyr (>= 1.0.3), tidyr (>= 1.1.2), purrr (>= 0.3.4), furrr (>= 0.2.2), ggplot2 (>= 3.3.3), ggforce (>= 0.3.2), grid (>= 4.0.2), vegan (>= 2.5-7), gstat (>= 2.0-6), sp (>= 1.4-5), methods (>= 4.0.2), SpatialExtremes (>= 2.0-9), ggrepel (>= 0.9.1), kriging (>= 1.1), plotly (>= 4.9.3), stringr (>= 1.4.0), future (>= 1.21.0), mice (>= 3.13.0), lattice (>= 0.20-41), nleqslv (>= 3.3.2), stats (>= 4.0.2), graphics (>= 4.0.2), grDevices (>= 4.0.2), magrittr (>= 2.0.1), pbapply (>= 1.4-3), metR (>= 0.9.1)
LinkingTo
Suggests	knitr, rmarkdown
SystemRequirements
Enhances
URL	http://synergyfinder.org/
Depends On Me
Imports Me
Suggests Me
Links To Me
Build Report

Package Archives

Follow Installation instructions to use this package in your R session.

Source Package	synergyfinder_2.4.16.tar.gz
Windows Binary	synergyfinder_2.4.16.zip
macOS 10.13 (High Sierra)	synergyfinder_2.4.16.tgz
Source Repository	git clone https://git.bioconductor.org/packages/synergyfinder
Source Repository (Developer Access)	git clone git@git.bioconductor.org:packages/synergyfinder
Package Short Url	https://bioconductor.org/packages/synergyfinder/
Package Downloads Report	Download Stats