Clustering and Visualizing RNA-Seq Expression Data using Grade of Membership Models


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Documentation for package ‘CountClust’ version 1.18.0

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AbundanceGoM GoM model fit for abundance data
BatchCorrectedCounts Obtain Batch effect Corrected counts
compare_omega Re-ordering cluster membership proportion matrices and Information calculation
compGoM compGoM: compare GoM model fits across K or across different runs through log-likelihood, BIC and null loglikelihood
ex.counts counts data for GTEx V6 Brain data for 200 genes
ExtractHighCorFeatures Extracting most highly correlated genes with GoM topics/clusters
ExtractTopFeatures Extracting top driving genes of GoM clusters
FitGoM Run Grade of Membership (GoM) model with multiple starting points !
GTExV6Brain.FitGoM GoM model fit for GTEx V6 Brain bulk-RNA data
handleNA Deal with NAs in the dataset!
MouseDeng2014.FitGoM GoM model fit for Deng et al 2014 single cell RNA-seq data on mouse
MouseJaitinSpleen.FitGoM GoM model fit for Jaitin et al 2014 single cell RNA-seq data on mouse
nullmodel_GoM Null models for Grade of Membership (GoM) cluster validation
RemoveSparseFeatures Removes features with a lot of 0 counts
StructureGGplot Struture plot using ggplot2