source("http://bioconductor.org/biocLite.R")
biocLite("Roleswitch")

Roleswitch

Infer miRNA-mRNA interactions using paired expression data from a single sample

Bioconductor version: 2.13

Infer Probabilities of MiRNA-mRNA Interaction Signature (ProMISe) using paired expression data from a single sample. Roleswitch operates in two phases by inferring the probability of mRNA (miRNA) being the targets ("targets") of miRNA (mRNA), taking into account the expression of all of the mRNAs (miRNAs) due to their potential competition for the same miRNA (mRNA). Due to dynamic miRNA repression in the cell, Roleswitch assumes that the total transcribed mRNA levels are higher than the observed (equilibrium) mRNA levels and iteratively updates the total transcription of each mRNA targets based on the above inference.

Author: Yue Li

Maintainer: Yue Li <yueli at cs.toronto.edu>

Installation

To install this package, start R and enter:

source("http://bioconductor.org/biocLite.R")
biocLite("Roleswitch")

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("Roleswitch")

 

PDF	R Script	Roleswitch
PDF		Reference Manual

Details

biocViews	Software, microRNA
Version	1.0.0
In Bioconductor since	BioC 2.13 (R-3.0)
License	GPL-2
Depends	R (>= 2.10), pracma, reshape, plotrix, microRNA, biomaRt, Biostrings, Biobase, DBI
Imports
Suggests	ggplot2
System Requirements
URL	http://www.cs.utoronto.ca/~yueli/roleswitch.html
Depends On Me
Imports Me
Suggests Me

Package Archives

Follow Installation instructions to use this package in your R session.

Package Source	Roleswitch_1.0.0.tar.gz
Windows Binary	Roleswitch_1.0.0.zip (32- & 64-bit)
Mac OS X 10.6 (Snow Leopard)	Roleswitch_1.0.0.tgz
Browse/checkout source	(username/password: readonly)
Package Downloads Report	Download Stats