Changes in version 1.3.5 (2017-04-25): o Move scater to Imports and add scater version o Remove lingering references to SCESets o Add option to use a normal distribution for library sizes in Splat simulations o Allow Splat dropout parameters to be specified by experiment, batch, group or cell o Add SparseDC simulation o Rename params in metadata slot of simulation to Params for consistency o Improve and colourise Params print output o Improve test coverage o Various other minor updates and bug fixes Changes in version 1.1.8 (2017-10-13): o Now published in Genome Biology! o Converted to the SingleCellExperiment object o Added new simulations: BASiCS, mfa, PhenoPath, ZINB-WaVE o Added batch effects to the Splat simulation. This required a change to the SplatParams object. o Improved scDD estimation o Added and improved comparison functions o Improved default Splat parameters and estimation o Improvements to the Lun2Params object o Added addGeneLength function o Updated simulation references o Various other minor updates and bug fixes Changes in version 0.99.16 (2017-04-23): o Splatter is a package for the simple simulation of single-cell RNA-seq data, including: o Multiple simulation models o Parameter estimation from real data o Functions for comparing simulations and real datasets o Simulation of complex groups and differentiation paths Changes in version 0.99.0 (2016-12-05): o Package prepared for Bioconductor submission.