Changes in version 1.1.4: o Added the clearSpikes() function to remove all spike-in information. o Added the clearSizeFactors() function to remove all size factor information. o Added the sizeFactorNames() function to query the available (named) size factor sets. o isSpike() with an unknown spike-in set in type= will no longer throw an error, and will quietly return NULL. o isSpike<- with type=NULL is deprecated in favour of clearSpikes() for removing existing spike-in information. All spike-in sets must also be explicitly named during assignment. o Added the LinearEmbeddingMatrix class for storing dimensionality reduction with loadings. Changes in version 1.0.0: o New package SingleCellExperiment, for representation of single-cell genomics data.