2017-12-18 Updating! Refine qtotal (R funtion: qtotalNormalized) 2017-07-18 Updating! Adapt aFold model for complex design with linear model (R funtion: ABSSeqlm) 2017-06-02 1) Updating! Introduce a new approach for normalization as qtotal (R funtion: qtotalNormalized) 2) aFold now moderates fold changes upon overall dispersion and gene-specific dispersion 2017-02-14 Updating! Adding new method: aFold to call DE via fold-change 2016-02-29 Updating! Enable the paired comparison by seting up 'paired' parameter in 'ABSDataSet' object 2015-08-24 This is the second version of ABSSeq. 1) Use NB distribution insead of GP to model the counts difference between conditions 2) Introduce an efficient outlier detection method: moderated MAD 3) Introduce penalty for dispersion estimation 4) Provide moderation of log2 fold-change at expression level and gene-specific dispersion