TF ranking plot

TF ranking plot shows statistic log10(Pvalue) assessing the anti-correlation level of TFs expression level with average DNA methylation level at sites with a given motif. By default, the top 3 associated TFs and the TF family members (dots in red) that are associated with that specific motif are labeled in the plot. But there is also a option show highlight only TF sub-family members (TCClass database classification)

TF ranking plot: family classification

Shown are TF ranking plots based on the score (log10(Pvalue)) of association between TF expression and DNA methylation of an enriched motif in the LUSC cancer type. The dashed line indicates the boundary of the top 5% association score. The top 3 associated TFs and the TF family members=(dots in red) that are associated with that specific motif are labeled in the plot

load("result/getTF.hypo.TFs.with.motif.pvalue.rda")
motif <- colnames(TF.meth.cor)[1]
TF.rank.plot(motif.pvalue = TF.meth.cor, 
             motif = motif,
             save = FALSE) 
## Retrieving TFClass family classification from ELMER.data.
## Retrieving TFClass subfamily classification from ELMER.data.
## $HXA9_HUMAN.H11MO.0.B
Shown are TF ranking plots based on the score (-log(P value)) of association between TF expression and DNA methylation of the enriched motif in the LUSC cancer type. The dashed line indicates the boundary of the top 5% association score. The top 3 associated TFs and the TF family members=(dots in red) that are associated with that specific motif are labeled in the plot

Shown are TF ranking plots based on the score (-log(P value)) of association between TF expression and DNA methylation of the enriched motif in the LUSC cancer type. The dashed line indicates the boundary of the top 5% association score. The top 3 associated TFs and the TF family members=(dots in red) that are associated with that specific motif are labeled in the plot