Rank Constrained Similarity Learning for single cell RNA sequencing data


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Documentation for package ‘RCSL’ version 1.16.0

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ann Cell type annotations of 'yan' datasets by Yan et al.
BDSM Calculate the bolock-diagnal matrix B min_B>=0, B*1=1, F'*F=I ||B - A||_1 + r*||B||^2 + 2*lambda*trace(F'*L*F)
EProjSimplexdiag Solve the problem: min 1/2*x'*L*x-x'*d s.t. x>=0, 1'x=1
EstClusters Estimate the optimal number of clusters C for clustering
EucDist Solve the problem: ||A-B||^2 = ||A||^2 + ||B||^2 - 2*A'*B
GenesFilter Perform the step of gene filtering to normalizaed gene expression data
getLineage Infer the development lineage based on the clustering results from RCSL and the pseudotime
NeigRepresent Calculate the neighbor representation of cells to the low-dimensional gene expression matrix
PlotMST Plot the visualization of constructed Minimum Spanning Tree based on the clustering results of RCSL
PlotPseudoTime Infer the pseudo-temporal ordering between the cell types using the distance from a cell type to the predefined starting cell type.
PlotTrajectory Infer the developmental trajectories based on the clustering results from RCSL
RCSL Perform the RCSL program
SimS Calculate the initial similarity matrix
TrajectoryAnalysis Trajectory analysis
yan A public scRNA-seq dataset by Yan et al.