check_ldsc_format |
Ensures that parameters are compatible with LDSC format |
compute_nsize |
Check for N column if not present and user wants, impute N based on user's sample size. *NOTE* this will be the same value for each SNP which is not necessarily correct and may cause issues down the line. N can also be inputted with "ldsc", "sum", "giant" or "metal" by passing one or multiple of these. |
download_vcf |
Download VCF file and its index file from Open GWAS |
find_sumstats |
Search Open GWAS for datasets matching criteria |
formatted_example |
Formatted example |
format_sumstats |
Check that summary statistics from GWAS are in a homogeneous format |
get_genome_builds |
Infer genome builds |
hg19ToHg38 |
UCSC Chain file hg19 to hg38 |
hg38ToHg19 |
UCSC Chain file hg38 to hg19 |
ieu-a-298 |
Local ieu-a-298 file from IEU Open GWAS |
import_sumstats |
Import full genome-wide GWAS summary statistics from Open GWAS |
index_tabular |
Tabix-index file: table |
is_tabix |
Is tabix |
liftover |
Genome build liftover |
list_sumstats |
List munged summary statistics |
load_ref_genome_data |
Load the reference genome data for SNPs of interest |
load_snp_loc_data |
Loads the SNP locations and alleles for Homo sapiens extracted from NCBI dbSNP Build 144. Reference genome version is dependent on user input. |
parse_logs |
Parse data from log files |
raw_ALSvcf |
GWAS Amyotrophic lateral sclerosis ieu open GWAS project - Subset |
raw_eduAttainOkbay |
GWAS Educational Attainment Okbay 2016 - Subset |
read_sumstats |
Determine summary statistics file type and read them into memory |
read_vcf |
Read in VCF file |
standardise_header |
Standardise the column headers in the Summary Statistics files |
sumstatsColHeaders |
Summary Statistics Column Headers |
write_sumstats |
Write sum stats file to disk |