## ----setup, include=FALSE----------------------------------------------------- knitr::opts_chunk$set(dpi = 300) knitr::opts_chunk$set(cache=FALSE) ## ---- eval = TRUE, echo = FALSE,hide=TRUE, message=FALSE,warning=FALSE-------- devtools::load_all() ## ---- eval = FALSE------------------------------------------------------------ # if (!requireNamespace("BiocManager", quietly=TRUE)) # install.packages("BiocManager") # BiocManager::install("SpidermiR") ## ---- eval = TRUE------------------------------------------------------------- org<-SpidermiRquery_species(species) ## ---- eval = TRUE, echo = FALSE----------------------------------------------- knitr::kable(org, digits = 2, caption = "List of species",row.names = TRUE) ## ---- eval = TRUE------------------------------------------------------------- net_type<-SpidermiRquery_networks_type(organismID=org[9,]) ## ---- eval = TRUE, echo = FALSE----------------------------------------------- net_type ## ---- eval = TRUE------------------------------------------------------------- net_shar_prot<-SpidermiRquery_spec_networks(organismID = org[9,], network = "SHpd") ## ---- eval = TRUE, echo = FALSE----------------------------------------------- net_shar_prot ## ---- eval = TRUE------------------------------------------------------------- out_net<-SpidermiRdownload_net(net_shar_prot) ## ---- eval = TRUE, echo = FALSE----------------------------------------------- str(out_net) ## ---- eval = FALSE------------------------------------------------------------ # mirna<-c('hsa-miR-567','hsa-miR-566') # SpidermiRdownload_miRNAprediction(mirna_list=mirna) ## ---- eval = FALSE------------------------------------------------------------ # list<-SpidermiRdownload_miRNAvalidate(validated) ## ---- eval = FALSE------------------------------------------------------------ # list_circ<-SpidermiRdownload_miRNAextra_cir(miRNAextra_cir) ## ---- eval = TRUE------------------------------------------------------------- list<-SpidermiRdownload_miRNAvalidate(validated) drug="TAMOXIFEN" drug_genetarget<-SpidermiRdownload_pharmacomir(list[1:100,],drug="TAMOXIFEN") ## ---- eval = TRUE, echo = FALSE----------------------------------------------- knitr::kable(drug_genetarget, digits = 2, caption = "miRNA associated with Tamoxifen",row.names = TRUE) ## ---- eval = TRUE------------------------------------------------------------- drug_genetarget<-SpidermiRdownload_drug_gene(drug_gene) ## ---- eval = TRUE------------------------------------------------------------- geneSymb_net<-SpidermiRprepare_NET(organismID = org[9,], data = out_net) ## ---- eval = TRUE, echo = FALSE----------------------------------------------- knitr::kable(geneSymb_net[[1]][1:5,c(1,2,3,5,8)], digits = 2, caption = "shared protein domain",row.names = FALSE) ## ---- eval = TRUE------------------------------------------------------------- biomark_of_interest<-c("hsa-let-7a","CDC34","hsa-miR-27a","PEX7","EPT1","FOX","hsa-miR-5a") miRNA_NET <-data.frame(V1=c('hsa-let-7a','CASP3','BRCA','hsa-miR-7a','hsa-miR-5a','SMAD','SOX'),V2=c('CASP3','TAMOXIFEN','MYC','PTEN','FOX','HIF1','P53'),stringsAsFactors=FALSE) GIdirect_net<-SpidermiRanalyze_direct_net(data=miRNA_NET,BI=biomark_of_interest) ## ---- eval = TRUE, echo = FALSE----------------------------------------------- str(GIdirect_net) ## ---- eval = FALSE------------------------------------------------------------ # # subnet<-SpidermiRanalyze_direct_subnetwork(data=miRNA_NET,BI=biomark_of_interest) # ## ---- eval = FALSE------------------------------------------------------------ # # GIdirect_net_neigh<-SpidermiRanalyze_subnetwork_neigh(data=miRNA_NET,BI=biomark_of_interest) ## ---- eval = FALSE------------------------------------------------------------ # top10_cent_gene<-SpidermiRanalyze_degree_centrality(miRNA_NET) ## ---- eval = FALSE------------------------------------------------------------ # comm<- SpidermiRanalyze_Community_detection(data=miRNA_NET,type="FC") ## ---- eval = FALSE------------------------------------------------------------ # cd_net<-SpidermiRanalyze_Community_detection_net(data=miRNA_NET,comm_det=comm,size=1) ## ---- eval = FALSE------------------------------------------------------------ # gi=c("P53","PTEN","KIT","CCND2") # mol<-SpidermiRanalyze_Community_detection_bi(data=comm,BI=gi) ## ---- eval = TRUE------------------------------------------------------------- SpidermiRvisualize_plot_target(data=miRNA_NET) ## ----fig.width=4, fig.height=4, eval = TRUE----------------------------------- SpidermiRvisualize_degree_dist(data=miRNA_NET) ## ---- fig.width=10, fig.height=10,eval = TRUE--------------------------------- SpidermiRvisualize_adj_matrix(data=miRNA_NET) ## ----fig.width=4, fig.height=4, eval = TRUE----------------------------------- SpidermiRvisualize_3Dbarplot(Edges_1net=1041003,Edges_2net=100016,Edges_3net=3008,Edges_4net=1493,Edges_5net=1598,NODES_1net=16502,NODES_2net=13338,NODES_3net=1429,NODES_4net=675,NODES_5net=712,nmiRNAs_1net=0,nmiRNAs_2net=74,nmiRNAs_3net=0,nmiRNAs_4net=0,nmiRNAs_5net=37) ## ---- eval = TRUE,echo = FALSE------------------------------------------------ B<-matrix( c("Gene network", "Validated miRNA-target","", "Predicted miRNA-target","","","", "Extracellular Circulating microRNAs", "Pharmaco-miR","", "GeneMania", "miRwalk","miRTarBase", "DIANA", "Miranda", "PicTar","TargetScan","miRandola","DGIdb","MATADOR", "Current","miRwalk2","miRTarBase 7","DIANA- 5.0","N/A","N/A","TargetScan7.1","miRandola v 02/2017","N/A","N/A", 2017,2015,2017,2013,2010,"N/A","2016",2017,2018,"N/A", "http://genemania.org/data/current/","http://zmf.umm.uni-heidelberg.de/apps/zmf/mirwalk2/downloads/vtm/hsa-vtm-gene.rdata.zip","http://mirtarbase.mbc.nctu.edu.tw/cache/download/7.0/miRTarBase_SE_WR.xls","https://bioconductor.org/packages/release/bioc/html/miRNAtap.html","https://bioconductor.org/packages/release/bioc/html/miRNAtap.html","https://bioconductor.org/packages/release/bioc/html/miRNAtap.html","https://bioconductor.org/packages/release/bioc/html/miRNAtap.html","http://mirandola.iit.cnr.it/download/miRandola_version_02_2017.txt","http://dgidb.org/data/interactions.tsv", "http://matador.embl.de/media/download/matador.tsv.gz" ), nrow=10, ncol=5) colnames(B)<-c("CATEGORY","EXTERNAL DATABASE","VERSION","LAST UPDATE","LINK") ## ---- eval = TRUE, echo = FALSE----------------------------------------------- knitr::kable(B, digits = 2, caption = "Features",row.names = FALSE) ## ----sessionInfo-------------------------------------------------------------- sessionInfo()