IMMAN

Minoo Ashtiani, Payman Nickchi, Abdollah Safari, Mehdi Mirzaie, Mohieddin Jafari

2019-10-29

IMMAN is specified to retrieve the interlog protein network shared across diverse species. For this aim, first we exceed orthology relationships among sequences from various species by iterating over any pair of input species, and using the Needleman-Wunsch alignment algorithm and a best reciprocal hit strategy to reach the orthologues through all versus all pairwise cross-species alignments. From orthology assignment, we derive Orthologous Protein sets (OPSs), an assortment of clusters of orthologues(maximum one per species) which will conform the nodes of the so-called Interolog Protein Network (IPN).

We exceed n species-specific interlog protein networks from STRING database, where each node maps to a single OPS in the IPN, and distinguish the edges of the outcome IPN by choosing only edges linking nodes in the IPN that also are linked in at least species-specific networks (where ‘k’ is set as a parameter).

A scoring system is used by the alignment process, which can be described as a set of values specified for quantifying the likelihood of one residue that has been substituted by another in an alignment. The scoring systems used by alignment procedure is called a substitution matrix and it can be achieved from statistical analysis of residue substitution data from sets of reputable alignments of highly relevent sequences. Using identityU value which ranges from 0 to 100, user would be able to specialize how the IPNs should be larger or not. As the value of identityU gets higher, the algorithm will find much similar orthologs and vice versa. We used gapOpening and gapExtension arguments to figure numeric values of ortholog proteins. For matching alignments of proteins if we skip a protein, gapOpening argument would be incremented. The smaller the amount of gap, protein alignements are more similar to each other. The score_threshold argument is specified for evaluating the similarity values between two proteins in substitutionMatrix. It differs from 0 to 100, however, the common use ranges from 25 to 30. The transference of interactionn among orthologs of different species called the interlog approach. We used Besthit argument to reach proteins which has the most similarity in all versus all protein alignment. If an interaction was exist between each pair of proteins of OPSs, an edge would be linked in the IPN. The coverage_threshold specifies the number of interactions that are exist among pair of proteins of OPSs. It differs from 1 to number of species. As much as the value of coverage_threshold was high, the final IPN would be more robust and usually smaller. NetworkShrinkage argument determine whether two similar OPSs which have ortholog proteins in common should be merged or not. If it was TRUE the resulting IPN would be smaller.

For using this package, we assume that the “CINNA” package has been properly installed into the R environment. After installations, the “CINNA” package can be loaded via

library(IMMAN)

For illustration, we will read two datasets from different species which can be accessed via:

data(Celegance)
data(FruitFly)

Then, we have to make a list of dataset species and set their taxanomy IDs.

ProteinLists = list(as.character(Celegance$V1), as.character(FruitFly$V1))

List1_Species_ID = 6239  # taxonomy ID Celegance
List2_Species_ID = 7227  # taxonomy ID FruitFly

Species_IDs  = c(List1_Species_ID, List2_Species_ID)

To continue, set the parameters to run the analysis. Here is a description of parameters in IMMAN. If you need more information you can refer to the paper.

identityU: Cut off value for selecting proteins whose alignment score is greater or equal than identityU.

substitutionMatrix: Which scoring matrix to be used for alignment setting gapOpening and gapExtension for alignment purposes.

For NetworkShrinkage, coverage, and BestHit refer to paper.

STRINGversion: Indicated which version of STRING database should program search in for the score of PPIs.

Then, we will set the argument values:

identityU = 30
substitutionMatrix = "BLOSUM62"
gapOpening = -8
gapExtension = -8
NetworkShrinkage = FALSE
coverage = 1
BestHit = TRUE
score_threshold = 400
STRINGversion="10"

Finally, we can run the IMMAN function:

output = IMMAN(ProteinLists, fileNames=NULL, Species_IDs,
              identityU, substitutionMatrix,
              gapOpening, gapExtension, BestHit,
              coverage, NetworkShrinkage,
              score_threshold, STRINGversion,
              InputDirectory = getwd())
## Step 1/4:Downloading amino acid sequences...
## Downloading amino acid sequences of List1
## Downloading amino acid sequences of List2
## Step 2/4: Alignment...
## Align List1 with List2
## Step 3/4: Detection in STRING...
## Detecting List1 in STRING
## Detecting List2 in STRING
## Step 4/4: Retrieving String Network...
## Retrieving List1
## Retrieving List2
## Producing IPN...
## DONE!

In order to see some particular parts of the result, you can use:

output$IPNEdges
##         node1   node2
## 41    OPS0001 OPS0004
## 91    OPS0001 OPS0009
## 191   OPS0001 OPS0019
## 211   OPS0001 OPS0021
## 251   OPS0001 OPS0025
## 271   OPS0001 OPS0027
## 301   OPS0001 OPS0030
## 311   OPS0001 OPS0031
## 361   OPS0001 OPS0036
## 371   OPS0001 OPS0037
## 441   OPS0001 OPS0044
## 491   OPS0001 OPS0049
## 551   OPS0001 OPS0055
## 611   OPS0001 OPS0061
## 231   OPS0002 OPS0023
## 561   OPS0002 OPS0056
## 71    OPS0004 OPS0007
## 911   OPS0004 OPS0009
## 111   OPS0004 OPS0011
## 121   OPS0004 OPS0012
## 171   OPS0004 OPS0017
## 241   OPS0004 OPS0024
## 2511  OPS0004 OPS0025
## 421   OPS0004 OPS0042
## 621   OPS0004 OPS0062
## 711   OPS0006 OPS0007
## 81    OPS0006 OPS0008
## 1211  OPS0006 OPS0012
## 151   OPS0006 OPS0015
## 161   OPS0006 OPS0016
## 221   OPS0006 OPS0022
## 2411  OPS0006 OPS0024
## 2512  OPS0006 OPS0025
## 261   OPS0006 OPS0026
## 281   OPS0006 OPS0028
## 291   OPS0006 OPS0029
## 3011  OPS0006 OPS0030
## 3111  OPS0006 OPS0031
## 341   OPS0006 OPS0034
## 3611  OPS0006 OPS0036
## 3711  OPS0006 OPS0037
## 381   OPS0006 OPS0038
## 391   OPS0006 OPS0039
## 461   OPS0006 OPS0046
## 471   OPS0006 OPS0047
## 481   OPS0006 OPS0048
## 501   OPS0006 OPS0050
## 511   OPS0006 OPS0051
## 581   OPS0006 OPS0058
## 591   OPS0006 OPS0059
## 6211  OPS0006 OPS0062
## 811   OPS0007 OPS0008
## 1111  OPS0007 OPS0011
## 1212  OPS0007 OPS0012
## 1511  OPS0007 OPS0015
## 1611  OPS0007 OPS0016
## 181   OPS0007 OPS0018
## 2211  OPS0007 OPS0022
## 2311  OPS0007 OPS0023
## 2412  OPS0007 OPS0024
## 2513  OPS0007 OPS0025
## 2611  OPS0007 OPS0026
## 2811  OPS0007 OPS0028
## 2911  OPS0007 OPS0029
## 3012  OPS0007 OPS0030
## 3112  OPS0007 OPS0031
## 3411  OPS0007 OPS0034
## 3612  OPS0007 OPS0036
## 3712  OPS0007 OPS0037
## 3811  OPS0007 OPS0038
## 3911  OPS0007 OPS0039
## 4711  OPS0007 OPS0047
## 4811  OPS0007 OPS0048
## 5011  OPS0007 OPS0050
## 5111  OPS0007 OPS0051
## 531   OPS0007 OPS0053
## 5811  OPS0007 OPS0058
## 5911  OPS0007 OPS0059
## 6212  OPS0007 OPS0062
## 1112  OPS0008 OPS0011
## 1213  OPS0008 OPS0012
## 1612  OPS0008 OPS0016
## 1811  OPS0008 OPS0018
## 2212  OPS0008 OPS0022
## 2312  OPS0008 OPS0023
## 2413  OPS0008 OPS0024
## 2514  OPS0008 OPS0025
## 2711  OPS0008 OPS0027
## 2912  OPS0008 OPS0029
## 3113  OPS0008 OPS0031
## 3412  OPS0008 OPS0034
## 3713  OPS0008 OPS0037
## 3812  OPS0008 OPS0038
## 3912  OPS0008 OPS0039
## 4211  OPS0008 OPS0042
## 4812  OPS0008 OPS0048
## 5112  OPS0008 OPS0051
## 5311  OPS0008 OPS0053
## 5912  OPS0008 OPS0059
## 6213  OPS0008 OPS0062
## 1113  OPS0009 OPS0011
## 1711  OPS0009 OPS0017
## 2111  OPS0009 OPS0021
## 2712  OPS0009 OPS0027
## 321   OPS0009 OPS0032
## 3613  OPS0009 OPS0036
## 3714  OPS0009 OPS0037
## 4212  OPS0009 OPS0042
## 4411  OPS0009 OPS0044
## 6111  OPS0009 OPS0061
## 4611  OPS0010 OPS0046
## 1214  OPS0011 OPS0012
## 1712  OPS0011 OPS0017
## 2213  OPS0011 OPS0022
## 2313  OPS0011 OPS0023
## 2414  OPS0011 OPS0024
## 2515  OPS0011 OPS0025
## 2713  OPS0011 OPS0027
## 2812  OPS0011 OPS0028
## 2913  OPS0011 OPS0029
## 521   OPS0011 OPS0052
## 6214  OPS0011 OPS0062
## 131   OPS0012 OPS0013
## 1512  OPS0012 OPS0015
## 1613  OPS0012 OPS0016
## 1812  OPS0012 OPS0018
## 2214  OPS0012 OPS0022
## 2314  OPS0012 OPS0023
## 2415  OPS0012 OPS0024
## 2516  OPS0012 OPS0025
## 2714  OPS0012 OPS0027
## 2813  OPS0012 OPS0028
## 2914  OPS0012 OPS0029
## 3013  OPS0012 OPS0030
## 3114  OPS0012 OPS0031
## 3413  OPS0012 OPS0034
## 3614  OPS0012 OPS0036
## 3715  OPS0012 OPS0037
## 3813  OPS0012 OPS0038
## 3913  OPS0012 OPS0039
## 4213  OPS0012 OPS0042
## 4712  OPS0012 OPS0047
## 4813  OPS0012 OPS0048
## 5012  OPS0012 OPS0050
## 5113  OPS0012 OPS0051
## 5312  OPS0012 OPS0053
## 5812  OPS0012 OPS0058
## 5913  OPS0012 OPS0059
## 6215  OPS0012 OPS0062
## 1614  OPS0015 OPS0016
## 1911  OPS0015 OPS0019
## 2215  OPS0015 OPS0022
## 2517  OPS0015 OPS0025
## 2814  OPS0015 OPS0028
## 2915  OPS0015 OPS0029
## 3014  OPS0015 OPS0030
## 3115  OPS0015 OPS0031
## 3615  OPS0015 OPS0036
## 3716  OPS0015 OPS0037
## 3814  OPS0015 OPS0038
## 3914  OPS0015 OPS0039
## 4713  OPS0015 OPS0047
## 4814  OPS0015 OPS0048
## 5013  OPS0015 OPS0050
## 5114  OPS0015 OPS0051
## 5813  OPS0015 OPS0058
## 5914  OPS0015 OPS0059
## 2216  OPS0016 OPS0022
## 2416  OPS0016 OPS0024
## 2612  OPS0016 OPS0026
## 2815  OPS0016 OPS0028
## 2916  OPS0016 OPS0029
## 3015  OPS0016 OPS0030
## 3116  OPS0016 OPS0031
## 3616  OPS0016 OPS0036
## 3717  OPS0016 OPS0037
## 3815  OPS0016 OPS0038
## 3915  OPS0016 OPS0039
## 411   OPS0016 OPS0041
## 4714  OPS0016 OPS0047
## 4815  OPS0016 OPS0048
## 5014  OPS0016 OPS0050
## 5115  OPS0016 OPS0051
## 5814  OPS0016 OPS0058
## 5915  OPS0016 OPS0059
## 6216  OPS0016 OPS0062
## 2715  OPS0017 OPS0027
## 5313  OPS0017 OPS0053
## 6217  OPS0017 OPS0062
## 2417  OPS0018 OPS0024
## 2816  OPS0018 OPS0028
## 2917  OPS0018 OPS0029
## 3211  OPS0018 OPS0032
## 4612  OPS0018 OPS0046
## 5211  OPS0018 OPS0052
## 601   OPS0018 OPS0060
## 201   OPS0019 OPS0020
## 2518  OPS0019 OPS0025
## 2817  OPS0019 OPS0028
## 3016  OPS0019 OPS0030
## 3617  OPS0019 OPS0036
## 3816  OPS0019 OPS0038
## 4715  OPS0019 OPS0047
## 5015  OPS0019 OPS0050
## 5815  OPS0019 OPS0058
## 6218  OPS0019 OPS0062
## 4911  OPS0020 OPS0049
## 2519  OPS0021 OPS0025
## 3017  OPS0021 OPS0030
## 3117  OPS0021 OPS0031
## 3618  OPS0021 OPS0036
## 3718  OPS0021 OPS0037
## 4111  OPS0021 OPS0041
## 4412  OPS0021 OPS0044
## 4912  OPS0021 OPS0049
## 5511  OPS0021 OPS0055
## 6112  OPS0021 OPS0061
## 2315  OPS0022 OPS0023
## 25110 OPS0022 OPS0025
## 2613  OPS0022 OPS0026
## 2716  OPS0022 OPS0027
## 2818  OPS0022 OPS0028
## 2918  OPS0022 OPS0029
## 3018  OPS0022 OPS0030
## 3118  OPS0022 OPS0031
## 3619  OPS0022 OPS0036
## 3719  OPS0022 OPS0037
## 3817  OPS0022 OPS0038
## 3916  OPS0022 OPS0039
## 4716  OPS0022 OPS0047
## 4816  OPS0022 OPS0048
## 5016  OPS0022 OPS0050
## 5116  OPS0022 OPS0051
## 571   OPS0022 OPS0057
## 5816  OPS0022 OPS0058
## 5916  OPS0022 OPS0059
## 6219  OPS0022 OPS0062
## 2418  OPS0023 OPS0024
## 25111 OPS0023 OPS0025
## 3414  OPS0023 OPS0034
## 451   OPS0023 OPS0045
## 4613  OPS0023 OPS0046
## 5314  OPS0023 OPS0053
## 62110 OPS0023 OPS0062
## 25112 OPS0024 OPS0025
## 2919  OPS0024 OPS0029
## 3119  OPS0024 OPS0031
## 3415  OPS0024 OPS0034
## 37110 OPS0024 OPS0037
## 3917  OPS0024 OPS0039
## 4817  OPS0024 OPS0048
## 5117  OPS0024 OPS0051
## 5315  OPS0024 OPS0053
## 5917  OPS0024 OPS0059
## 62111 OPS0024 OPS0062
## 2819  OPS0025 OPS0028
## 3019  OPS0025 OPS0030
## 31110 OPS0025 OPS0031
## 36110 OPS0025 OPS0036
## 3818  OPS0025 OPS0038
## 4717  OPS0025 OPS0047
## 4818  OPS0025 OPS0048
## 5017  OPS0025 OPS0050
## 5316  OPS0025 OPS0053
## 5817  OPS0025 OPS0058
## 62112 OPS0025 OPS0062
## 29110 OPS0026 OPS0029
## 31111 OPS0026 OPS0031
## 37111 OPS0026 OPS0037
## 3918  OPS0026 OPS0039
## 4819  OPS0026 OPS0048
## 5118  OPS0026 OPS0051
## 5918  OPS0026 OPS0059
## 3212  OPS0027 OPS0032
## 4214  OPS0027 OPS0042
## 29111 OPS0028 OPS0029
## 30110 OPS0028 OPS0030
## 31112 OPS0028 OPS0031
## 36111 OPS0028 OPS0036
## 37112 OPS0028 OPS0037
## 3819  OPS0028 OPS0038
## 3919  OPS0028 OPS0039
## 4718  OPS0028 OPS0047
## 48110 OPS0028 OPS0048
## 5018  OPS0028 OPS0050
## 5119  OPS0028 OPS0051
## 5818  OPS0028 OPS0058
## 5919  OPS0028 OPS0059
## 6011  OPS0028 OPS0060
## 30111 OPS0029 OPS0030
## 31113 OPS0029 OPS0031
## 36112 OPS0029 OPS0036
## 37113 OPS0029 OPS0037
## 38110 OPS0029 OPS0038
## 39110 OPS0029 OPS0039
## 4112  OPS0029 OPS0041
## 4719  OPS0029 OPS0047
## 48111 OPS0029 OPS0048
## 5019  OPS0029 OPS0050
## 51110 OPS0029 OPS0051
## 5819  OPS0029 OPS0058
## 59110 OPS0029 OPS0059
## 6012  OPS0029 OPS0060
## 62113 OPS0029 OPS0062
## 31114 OPS0030 OPS0031
## 36113 OPS0030 OPS0036
## 37114 OPS0030 OPS0037
## 38111 OPS0030 OPS0038
## 39111 OPS0030 OPS0039
## 4413  OPS0030 OPS0044
## 47110 OPS0030 OPS0047
## 48112 OPS0030 OPS0048
## 4913  OPS0030 OPS0049
## 50110 OPS0030 OPS0050
## 51111 OPS0030 OPS0051
## 5512  OPS0030 OPS0055
## 58110 OPS0030 OPS0058
## 59111 OPS0030 OPS0059
## 6113  OPS0030 OPS0061
## 36114 OPS0031 OPS0036
## 37115 OPS0031 OPS0037
## 38112 OPS0031 OPS0038
## 39112 OPS0031 OPS0039
## 4113  OPS0031 OPS0041
## 4414  OPS0031 OPS0044
## 47111 OPS0031 OPS0047
## 48113 OPS0031 OPS0048
## 4914  OPS0031 OPS0049
## 50111 OPS0031 OPS0050
## 51112 OPS0031 OPS0051
## 5513  OPS0031 OPS0055
## 58111 OPS0031 OPS0058
## 59112 OPS0031 OPS0059
## 6114  OPS0031 OPS0061
## 62114 OPS0031 OPS0062
## 331   OPS0032 OPS0033
## 5212  OPS0032 OPS0052
## 62115 OPS0032 OPS0062
## 4614  OPS0033 OPS0046
## 5611  OPS0033 OPS0056
## 5317  OPS0034 OPS0053
## 62116 OPS0034 OPS0062
## 62117 OPS0035 OPS0062
## 37116 OPS0036 OPS0037
## 38113 OPS0036 OPS0038
## 39113 OPS0036 OPS0039
## 4415  OPS0036 OPS0044
## 47112 OPS0036 OPS0047
## 48114 OPS0036 OPS0048
## 4915  OPS0036 OPS0049
## 50112 OPS0036 OPS0050
## 51113 OPS0036 OPS0051
## 5514  OPS0036 OPS0055
## 58112 OPS0036 OPS0058
## 59113 OPS0036 OPS0059
## 6115  OPS0036 OPS0061
## 38114 OPS0037 OPS0038
## 39114 OPS0037 OPS0039
## 4114  OPS0037 OPS0041
## 4416  OPS0037 OPS0044
## 47113 OPS0037 OPS0047
## 48115 OPS0037 OPS0048
## 4916  OPS0037 OPS0049
## 50113 OPS0037 OPS0050
## 51114 OPS0037 OPS0051
## 5515  OPS0037 OPS0055
## 58113 OPS0037 OPS0058
## 59114 OPS0037 OPS0059
## 6116  OPS0037 OPS0061
## 62118 OPS0037 OPS0062
## 39115 OPS0038 OPS0039
## 4215  OPS0038 OPS0042
## 47114 OPS0038 OPS0047
## 48116 OPS0038 OPS0048
## 50114 OPS0038 OPS0050
## 51115 OPS0038 OPS0051
## 5516  OPS0038 OPS0055
## 5711  OPS0038 OPS0057
## 58114 OPS0038 OPS0058
## 59115 OPS0038 OPS0059
## 631   OPS0038 OPS0063
## 4115  OPS0039 OPS0041
## 4216  OPS0039 OPS0042
## 47115 OPS0039 OPS0047
## 48117 OPS0039 OPS0048
## 50115 OPS0039 OPS0050
## 51116 OPS0039 OPS0051
## 5517  OPS0039 OPS0055
## 5712  OPS0039 OPS0057
## 58115 OPS0039 OPS0058
## 59116 OPS0039 OPS0059
## 62119 OPS0039 OPS0062
## 6311  OPS0039 OPS0063
## 5213  OPS0040 OPS0052
## 48118 OPS0041 OPS0048
## 50116 OPS0041 OPS0050
## 51117 OPS0041 OPS0051
## 5612  OPS0041 OPS0056
## 59117 OPS0041 OPS0059
## 58116 OPS0042 OPS0058
## 59118 OPS0042 OPS0059
## 4917  OPS0044 OPS0049
## 5518  OPS0044 OPS0055
## 6117  OPS0044 OPS0061
## 4615  OPS0045 OPS0046
## 62120 OPS0045 OPS0062
## 5318  OPS0046 OPS0053
## 6013  OPS0046 OPS0060
## 48119 OPS0047 OPS0048
## 50117 OPS0047 OPS0050
## 51118 OPS0047 OPS0051
## 58117 OPS0047 OPS0058
## 59119 OPS0047 OPS0059
## 6118  OPS0047 OPS0061
## 6312  OPS0047 OPS0063
## 50118 OPS0048 OPS0050
## 51119 OPS0048 OPS0051
## 58118 OPS0048 OPS0058
## 59120 OPS0048 OPS0059
## 6119  OPS0048 OPS0061
## 62121 OPS0048 OPS0062
## 6313  OPS0048 OPS0063
## 5519  OPS0049 OPS0055
## 5713  OPS0049 OPS0057
## 61110 OPS0049 OPS0061
## 51120 OPS0050 OPS0051
## 5613  OPS0050 OPS0056
## 58119 OPS0050 OPS0058
## 59121 OPS0050 OPS0059
## 5614  OPS0051 OPS0056
## 58120 OPS0051 OPS0058
## 59122 OPS0051 OPS0059
## 62122 OPS0051 OPS0062
## 5319  OPS0052 OPS0053
## 6014  OPS0052 OPS0060
## 62123 OPS0053 OPS0062
## 55110 OPS0054 OPS0055
## 5714  OPS0054 OPS0057
## 5715  OPS0055 OPS0057
## 61111 OPS0055 OPS0061
## 61112 OPS0057 OPS0061
## 59123 OPS0058 OPS0059
## 62124 OPS0058 OPS0062
## 6314  OPS0058 OPS0063
## 62125 OPS0059 OPS0062
## 6315  OPS0059 OPS0063
output$IPNNodes
##                node1            node2 OPSLabel
## 1       6239.C18E9.6 7227.FBpp0085338  OPS0001
## 2       6239.R07B7.5 7227.FBpp0088005  OPS0002
## 3     6239.Y67H2A.4a 7227.FBpp0111941  OPS0003
## 4  6239.Y22D7AL.5a.2 7227.FBpp0073290  OPS0004
## 5     6239.R07G3.5.2 7227.FBpp0070350  OPS0005
## 6       6239.MTCE.31 7227.FBpp0100177  OPS0006
## 7     6239.F42A8.2.1 7227.FBpp0085489  OPS0007
## 8     6239.H28O16.1a 7227.FBpp0071794  OPS0008
## 9    6239.C34C12.8.1 7227.FBpp0086795  OPS0009
## 10    6239.ZK370.5.1 7227.FBpp0111805  OPS0010
## 11   6239.F10D11.1.2 7227.FBpp0086226  OPS0011
## 12   6239.C34E10.6.2 7227.FBpp0305828  OPS0012
## 13    6239.M01F1.3.3 7227.FBpp0288705  OPS0013
## 14     6239.Y47G6A.8 7227.FBpp0086223  OPS0014
## 15    6239.E04A4.7.3 7227.FBpp0083137  OPS0015
## 16      6239.MTCE.21 7227.FBpp0083137  OPS0016
## 17    6239.C34B2.6.1 7227.FBpp0271918  OPS0017
## 18  6239.F13D12.4a.2 7227.FBpp0070087  OPS0018
## 19    6239.ZK1248.14 7227.FBpp0070873  OPS0019
## 20   6239.K08F11.5.2 7227.FBpp0302814  OPS0020
## 21    6239.C47G2.3.1 7227.FBpp0083078  OPS0021
## 22  6239.Y37D8A.14.2 7227.FBpp0081947  OPS0022
## 23    6239.C05G5.4.1 7227.FBpp0073010  OPS0023
## 24    6239.C03G5.1.2 7227.FBpp0085736  OPS0024
## 25    6239.R05G6.7.2 7227.FBpp0079772  OPS0025
## 26     6239.H06I04.2 7227.FBpp0076607  OPS0026
## 27    6239.C29E4.8.1 7227.FBpp0072072  OPS0027
## 28    6239.E04A4.7.3 7227.FBpp0086748  OPS0028
## 29      6239.MTCE.21 7227.FBpp0086748  OPS0029
## 30    6239.E04A4.7.3 7227.FBpp0086555  OPS0030
## 31      6239.MTCE.21 7227.FBpp0086555  OPS0031
## 32      6239.B0250.5 7227.FBpp0085821  OPS0032
## 33     6239.F02A9.4a 7227.FBpp0085460  OPS0033
## 34     6239.ZK836.2a 7227.FBpp0085117  OPS0034
## 35   6239.W02B12.9.2 7227.FBpp0084635  OPS0035
## 36    6239.E04A4.7.3 7227.FBpp0082657  OPS0036
## 37      6239.MTCE.21 7227.FBpp0082657  OPS0037
## 38    6239.E04A4.7.3 7227.FBpp0082412  OPS0038
## 39      6239.MTCE.21 7227.FBpp0082412  OPS0039
## 40   6239.ZK1128.1.2 7227.FBpp0081828  OPS0040
## 41   6239.F57B9.4b.1 7227.FBpp0081347  OPS0041
## 42   6239.F29C12.4.2 7227.FBpp0079041  OPS0042
## 43     6239.C08F8.2a 7227.FBpp0271517  OPS0043
## 44    6239.E04A4.5.2 7227.FBpp0078430  OPS0044
## 45    6239.F49E8.5.1 7227.FBpp0077414  OPS0045
## 46    6239.T08G2.3.1 7227.FBpp0076520  OPS0046
## 47    6239.E04A4.7.3 7227.FBpp0291478  OPS0047
## 48      6239.MTCE.21 7227.FBpp0291478  OPS0048
## 49        6239.DY3.1 7227.FBpp0075820  OPS0049
## 50    6239.E04A4.7.3 7227.FBpp0298344  OPS0050
## 51      6239.MTCE.21 7227.FBpp0298344  OPS0051
## 52  6239.C16A3.10a.1 7227.FBpp0074729  OPS0052
## 53    6239.F43G9.1.2 7227.FBpp0300338  OPS0053
## 54  6239.Y55F3AM.1.1 7227.FBpp0073762  OPS0054
## 55    6239.C06G3.11a 7227.FBpp0073606  OPS0055
## 56      6239.ZK652.9 7227.FBpp0073568  OPS0056
## 57    6239.T08B2.8.2 7227.FBpp0303832  OPS0057
## 58    6239.E04A4.7.3 7227.FBpp0072334  OPS0058
## 59      6239.MTCE.21 7227.FBpp0072334  OPS0059
## 60   6239.Y38F1A.6.6 7227.FBpp0071759  OPS0060
## 61 6239.Y66D12A.22.2 7227.FBpp0071593  OPS0061
## 62    6239.T20G5.2.2 7227.FBpp0070871  OPS0062
## 63   6239.B0035.16.1 7227.FBpp0070168  OPS0063
output$Networks
## [[1]]
##                 from                to
## 1     6239.C03G5.1.2    6239.C05G5.4.1
## 2       6239.B0250.5  6239.C16A3.10a.1
## 3     6239.C06G3.11a      6239.C18E9.6
## 4       6239.C18E9.6    6239.C29E4.8.1
## 5     6239.C29E4.8.1    6239.C34B2.6.1
## 6       6239.B0250.5   6239.C34C12.8.1
## 7       6239.C18E9.6   6239.C34C12.8.1
## 8     6239.C29E4.8.1   6239.C34C12.8.1
## 9     6239.C34B2.6.1   6239.C34C12.8.1
## 10    6239.C03G5.1.2   6239.C34E10.6.2
## 11    6239.C05G5.4.1   6239.C34E10.6.2
## 12    6239.C29E4.8.1   6239.C34E10.6.2
## 13    6239.C06G3.11a    6239.C47G2.3.1
## 14      6239.C18E9.6    6239.C47G2.3.1
## 15   6239.C34C12.8.1    6239.C47G2.3.1
## 16    6239.C06G3.11a        6239.DY3.1
## 17      6239.C18E9.6        6239.DY3.1
## 18    6239.C47G2.3.1        6239.DY3.1
## 19    6239.C06G3.11a    6239.E04A4.5.2
## 20      6239.C18E9.6    6239.E04A4.5.2
## 21   6239.C34C12.8.1    6239.E04A4.5.2
## 22    6239.C47G2.3.1    6239.E04A4.5.2
## 23        6239.DY3.1    6239.E04A4.5.2
## 24   6239.C34E10.6.2    6239.E04A4.7.3
## 25  6239.C16A3.10a.1   6239.F10D11.1.2
## 26    6239.C34B2.6.1   6239.F10D11.1.2
## 27   6239.C34C12.8.1   6239.F10D11.1.2
## 28      6239.B0250.5  6239.F13D12.4a.2
## 29    6239.C03G5.1.2  6239.F13D12.4a.2
## 30   6239.C34E10.6.2  6239.F13D12.4a.2
## 31    6239.C29E4.8.1   6239.F29C12.4.2
## 32   6239.C34C12.8.1   6239.F29C12.4.2
## 33   6239.C34E10.6.2   6239.F29C12.4.2
## 34    6239.C03G5.1.2    6239.F42A8.2.1
## 35    6239.C05G5.4.1    6239.F42A8.2.1
## 36   6239.C34E10.6.2    6239.F42A8.2.1
## 37    6239.E04A4.7.3    6239.F42A8.2.1
## 38   6239.F10D11.1.2    6239.F42A8.2.1
## 39  6239.F13D12.4a.2    6239.F42A8.2.1
## 40    6239.C03G5.1.2    6239.F43G9.1.2
## 41    6239.C05G5.4.1    6239.F43G9.1.2
## 42  6239.C16A3.10a.1    6239.F43G9.1.2
## 43    6239.C34B2.6.1    6239.F43G9.1.2
## 44   6239.C34E10.6.2    6239.F43G9.1.2
## 45    6239.F42A8.2.1    6239.F43G9.1.2
## 46    6239.C47G2.3.1   6239.F57B9.4b.1
## 47    6239.C03G5.1.2    6239.H28O16.1a
## 48    6239.C05G5.4.1    6239.H28O16.1a
## 49    6239.C29E4.8.1    6239.H28O16.1a
## 50   6239.C34E10.6.2    6239.H28O16.1a
## 51   6239.F10D11.1.2    6239.H28O16.1a
## 52   6239.F29C12.4.2    6239.H28O16.1a
## 53    6239.F42A8.2.1    6239.H28O16.1a
## 54    6239.F43G9.1.2    6239.H28O16.1a
## 55   6239.C34E10.6.2    6239.M01F1.3.3
## 56    6239.C03G5.1.2      6239.MTCE.21
## 57   6239.C34E10.6.2      6239.MTCE.21
## 58    6239.E04A4.7.3      6239.MTCE.21
## 59    6239.F42A8.2.1      6239.MTCE.21
## 60   6239.F57B9.4b.1      6239.MTCE.21
## 61     6239.H06I04.2      6239.MTCE.21
## 62    6239.H28O16.1a      6239.MTCE.21
## 63    6239.C03G5.1.2      6239.MTCE.31
## 64   6239.C34E10.6.2      6239.MTCE.31
## 65    6239.E04A4.7.3      6239.MTCE.31
## 66    6239.F42A8.2.1      6239.MTCE.31
## 67     6239.H06I04.2      6239.MTCE.31
## 68    6239.H28O16.1a      6239.MTCE.31
## 69      6239.MTCE.21      6239.MTCE.31
## 70    6239.C03G5.1.2    6239.R05G6.7.2
## 71      6239.C18E9.6    6239.R05G6.7.2
## 72   6239.C34E10.6.2    6239.R05G6.7.2
## 73    6239.C47G2.3.1    6239.R05G6.7.2
## 74    6239.E04A4.7.3    6239.R05G6.7.2
## 75    6239.F42A8.2.1    6239.R05G6.7.2
## 76    6239.H28O16.1a    6239.R05G6.7.2
## 77      6239.MTCE.31    6239.R05G6.7.2
## 78    6239.C05G5.4.1      6239.R07B7.5
## 79    6239.C06G3.11a    6239.T08B2.8.2
## 80        6239.DY3.1    6239.T08B2.8.2
## 81    6239.C05G5.4.1    6239.T08G2.3.1
## 82     6239.F02A9.4a    6239.T08G2.3.1
## 83    6239.F43G9.1.2    6239.T08G2.3.1
## 84    6239.C03G5.1.2    6239.T20G5.2.2
## 85    6239.C05G5.4.1    6239.T20G5.2.2
## 86    6239.C34B2.6.1    6239.T20G5.2.2
## 87   6239.C34E10.6.2    6239.T20G5.2.2
## 88   6239.F10D11.1.2    6239.T20G5.2.2
## 89    6239.F42A8.2.1    6239.T20G5.2.2
## 90    6239.F43G9.1.2    6239.T20G5.2.2
## 91    6239.F49E8.5.1    6239.T20G5.2.2
## 92    6239.H28O16.1a    6239.T20G5.2.2
## 93      6239.MTCE.21    6239.T20G5.2.2
## 94    6239.R05G6.7.2    6239.T20G5.2.2
## 95    6239.T20G5.2.2   6239.W02B12.9.2
## 96    6239.C03G5.1.2 6239.Y22D7AL.5a.2
## 97      6239.C18E9.6 6239.Y22D7AL.5a.2
## 98    6239.C34B2.6.1 6239.Y22D7AL.5a.2
## 99   6239.C34C12.8.1 6239.Y22D7AL.5a.2
## 100  6239.C34E10.6.2 6239.Y22D7AL.5a.2
## 101  6239.F10D11.1.2 6239.Y22D7AL.5a.2
## 102  6239.F29C12.4.2 6239.Y22D7AL.5a.2
## 103   6239.F42A8.2.1 6239.Y22D7AL.5a.2
## 104   6239.R05G6.7.2 6239.Y22D7AL.5a.2
## 105   6239.T20G5.2.2 6239.Y22D7AL.5a.2
## 106  6239.C34E10.6.2  6239.Y37D8A.14.2
## 107   6239.E04A4.7.3  6239.Y37D8A.14.2
## 108  6239.F10D11.1.2  6239.Y37D8A.14.2
## 109   6239.F42A8.2.1  6239.Y37D8A.14.2
## 110    6239.H06I04.2  6239.Y37D8A.14.2
## 111   6239.H28O16.1a  6239.Y37D8A.14.2
## 112     6239.MTCE.21  6239.Y37D8A.14.2
## 113     6239.MTCE.31  6239.Y37D8A.14.2
## 114   6239.R05G6.7.2  6239.Y37D8A.14.2
## 115   6239.T20G5.2.2  6239.Y37D8A.14.2
## 116 6239.C16A3.10a.1   6239.Y38F1A.6.6
## 117 6239.F13D12.4a.2   6239.Y38F1A.6.6
## 118   6239.T08G2.3.1   6239.Y38F1A.6.6
## 119   6239.C06G3.11a 6239.Y66D12A.22.2
## 120     6239.C18E9.6 6239.Y66D12A.22.2
## 121  6239.C34C12.8.1 6239.Y66D12A.22.2
## 122   6239.C47G2.3.1 6239.Y66D12A.22.2
## 123       6239.DY3.1 6239.Y66D12A.22.2
## 124   6239.E04A4.5.2 6239.Y66D12A.22.2
## 125   6239.T08B2.8.2 6239.Y66D12A.22.2
## 126     6239.C18E9.6    6239.ZK1248.14
## 127   6239.E04A4.7.3    6239.ZK1248.14
## 128  6239.K08F11.5.2    6239.ZK1248.14
## 129   6239.R05G6.7.2    6239.ZK1248.14
## 130   6239.C03G5.1.2     6239.ZK836.2a
## 131   6239.C05G5.4.1     6239.ZK836.2a
## 132  6239.C34E10.6.2     6239.ZK836.2a
## 133   6239.F42A8.2.1     6239.ZK836.2a
## 134   6239.F43G9.1.2     6239.ZK836.2a
## 135   6239.H28O16.1a     6239.ZK836.2a
## 136     6239.MTCE.31     6239.ZK836.2a
## 137   6239.T20G5.2.2     6239.ZK836.2a
## 138    6239.F02A9.4a      6239.ZK652.9
## 139  6239.F57B9.4b.1      6239.ZK652.9
## 140     6239.R07B7.5      6239.ZK652.9
## 141 6239.C16A3.10a.1   6239.ZK1128.1.2
## 
## [[2]]
##                 from               to
## 1   7227.FBpp0070871 7227.FBpp0070873
## 2   7227.FBpp0070087 7227.FBpp0071759
## 3   7227.FBpp0070087 7227.FBpp0071794
## 4   7227.FBpp0070871 7227.FBpp0071794
## 5   7227.FBpp0071794 7227.FBpp0072072
## 6   7227.FBpp0070168 7227.FBpp0072334
## 7   7227.FBpp0070871 7227.FBpp0072334
## 8   7227.FBpp0070871 7227.FBpp0073010
## 9   7227.FBpp0071794 7227.FBpp0073010
## 10  7227.FBpp0070871 7227.FBpp0073290
## 11  7227.FBpp0071593 7227.FBpp0073606
## 12  7227.FBpp0073606 7227.FBpp0073762
## 13  7227.FBpp0070087 7227.FBpp0074729
## 14  7227.FBpp0071759 7227.FBpp0074729
## 15  7227.FBpp0071593 7227.FBpp0075820
## 16  7227.FBpp0073606 7227.FBpp0075820
## 17  7227.FBpp0070087 7227.FBpp0076520
## 18  7227.FBpp0071759 7227.FBpp0076520
## 19  7227.FBpp0073010 7227.FBpp0076520
## 20  7227.FBpp0070871 7227.FBpp0077414
## 21  7227.FBpp0073010 7227.FBpp0077414
## 22  7227.FBpp0076520 7227.FBpp0077414
## 23  7227.FBpp0071593 7227.FBpp0078430
## 24  7227.FBpp0073606 7227.FBpp0078430
## 25  7227.FBpp0075820 7227.FBpp0078430
## 26  7227.FBpp0071794 7227.FBpp0079041
## 27  7227.FBpp0072072 7227.FBpp0079041
## 28  7227.FBpp0072334 7227.FBpp0079041
## 29  7227.FBpp0073290 7227.FBpp0079041
## 30  7227.FBpp0070871 7227.FBpp0079772
## 31  7227.FBpp0070873 7227.FBpp0079772
## 32  7227.FBpp0071794 7227.FBpp0079772
## 33  7227.FBpp0073010 7227.FBpp0079772
## 34  7227.FBpp0073290 7227.FBpp0079772
## 35  7227.FBpp0073568 7227.FBpp0081347
## 36  7227.FBpp0070871 7227.FBpp0081947
## 37  7227.FBpp0071794 7227.FBpp0081947
## 38  7227.FBpp0072072 7227.FBpp0081947
## 39  7227.FBpp0073010 7227.FBpp0081947
## 40  7227.FBpp0076607 7227.FBpp0081947
## 41  7227.FBpp0079772 7227.FBpp0081947
## 42  7227.FBpp0070168 7227.FBpp0082412
## 43  7227.FBpp0071794 7227.FBpp0082412
## 44  7227.FBpp0073606 7227.FBpp0082412
## 45  7227.FBpp0079041 7227.FBpp0082412
## 46  7227.FBpp0071593 7227.FBpp0082657
## 47  7227.FBpp0073606 7227.FBpp0082657
## 48  7227.FBpp0075820 7227.FBpp0082657
## 49  7227.FBpp0078430 7227.FBpp0082657
## 50  7227.FBpp0071593 7227.FBpp0083078
## 51  7227.FBpp0073606 7227.FBpp0083078
## 52  7227.FBpp0075820 7227.FBpp0083078
## 53  7227.FBpp0078430 7227.FBpp0083078
## 54  7227.FBpp0079772 7227.FBpp0083078
## 55  7227.FBpp0081347 7227.FBpp0083078
## 56  7227.FBpp0082657 7227.FBpp0083078
## 57  7227.FBpp0070871 7227.FBpp0085117
## 58  7227.FBpp0071794 7227.FBpp0085117
## 59  7227.FBpp0073010 7227.FBpp0085117
## 60  7227.FBpp0070873 7227.FBpp0085338
## 61  7227.FBpp0071593 7227.FBpp0085338
## 62  7227.FBpp0073606 7227.FBpp0085338
## 63  7227.FBpp0075820 7227.FBpp0085338
## 64  7227.FBpp0078430 7227.FBpp0085338
## 65  7227.FBpp0079772 7227.FBpp0085338
## 66  7227.FBpp0082657 7227.FBpp0085338
## 67  7227.FBpp0083078 7227.FBpp0085338
## 68  7227.FBpp0073568 7227.FBpp0085460
## 69  7227.FBpp0076520 7227.FBpp0085460
## 70  7227.FBpp0070087 7227.FBpp0085489
## 71  7227.FBpp0070871 7227.FBpp0085489
## 72  7227.FBpp0071794 7227.FBpp0085489
## 73  7227.FBpp0073010 7227.FBpp0085489
## 74  7227.FBpp0076607 7227.FBpp0085489
## 75  7227.FBpp0079772 7227.FBpp0085489
## 76  7227.FBpp0081947 7227.FBpp0085489
## 77  7227.FBpp0085117 7227.FBpp0085489
## 78  7227.FBpp0070087 7227.FBpp0085736
## 79  7227.FBpp0070871 7227.FBpp0085736
## 80  7227.FBpp0071794 7227.FBpp0085736
## 81  7227.FBpp0073010 7227.FBpp0085736
## 82  7227.FBpp0079772 7227.FBpp0085736
## 83  7227.FBpp0085117 7227.FBpp0085736
## 84  7227.FBpp0085489 7227.FBpp0085736
## 85  7227.FBpp0070087 7227.FBpp0085821
## 86  7227.FBpp0070871 7227.FBpp0085821
## 87  7227.FBpp0072072 7227.FBpp0085821
## 88  7227.FBpp0074729 7227.FBpp0085821
## 89  7227.FBpp0085460 7227.FBpp0085821
## 90  7227.FBpp0070871 7227.FBpp0086226
## 91  7227.FBpp0071794 7227.FBpp0086226
## 92  7227.FBpp0072072 7227.FBpp0086226
## 93  7227.FBpp0073010 7227.FBpp0086226
## 94  7227.FBpp0073290 7227.FBpp0086226
## 95  7227.FBpp0079772 7227.FBpp0086226
## 96  7227.FBpp0081947 7227.FBpp0086226
## 97  7227.FBpp0085489 7227.FBpp0086226
## 98  7227.FBpp0085736 7227.FBpp0086226
## 99  7227.FBpp0071593 7227.FBpp0086555
## 100 7227.FBpp0073606 7227.FBpp0086555
## 101 7227.FBpp0075820 7227.FBpp0086555
## 102 7227.FBpp0078430 7227.FBpp0086555
## 103 7227.FBpp0079772 7227.FBpp0086555
## 104 7227.FBpp0083078 7227.FBpp0086555
## 105 7227.FBpp0085338 7227.FBpp0086555
## 106 7227.FBpp0070087 7227.FBpp0086748
## 107 7227.FBpp0071759 7227.FBpp0086748
## 108 7227.FBpp0085489 7227.FBpp0086748
## 109 7227.FBpp0086226 7227.FBpp0086748
## 110 7227.FBpp0071593 7227.FBpp0086795
## 111 7227.FBpp0073290 7227.FBpp0086795
## 112 7227.FBpp0078430 7227.FBpp0086795
## 113 7227.FBpp0079041 7227.FBpp0086795
## 114 7227.FBpp0082657 7227.FBpp0086795
## 115 7227.FBpp0083078 7227.FBpp0086795
## 116 7227.FBpp0085338 7227.FBpp0086795
## 117 7227.FBpp0085821 7227.FBpp0086795
## 118 7227.FBpp0086226 7227.FBpp0086795
## 119 7227.FBpp0073010 7227.FBpp0088005
## 120 7227.FBpp0073568 7227.FBpp0088005
## 121 7227.FBpp0070871 7227.FBpp0100177
## 122 7227.FBpp0071794 7227.FBpp0100177
## 123 7227.FBpp0076520 7227.FBpp0100177
## 124 7227.FBpp0076607 7227.FBpp0100177
## 125 7227.FBpp0079772 7227.FBpp0100177
## 126 7227.FBpp0081947 7227.FBpp0100177
## 127 7227.FBpp0085117 7227.FBpp0100177
## 128 7227.FBpp0085489 7227.FBpp0100177
## 129 7227.FBpp0085736 7227.FBpp0100177
## 130 7227.FBpp0076520 7227.FBpp0111805
## 131 7227.FBpp0073290 7227.FBpp0271918
## 132 7227.FBpp0086795 7227.FBpp0271918
## 133 7227.FBpp0070168 7227.FBpp0291478
## 134 7227.FBpp0071593 7227.FBpp0291478
## 135 7227.FBpp0079772 7227.FBpp0291478
## 136 7227.FBpp0082412 7227.FBpp0291478
## 137 7227.FBpp0070871 7227.FBpp0300338
## 138 7227.FBpp0071794 7227.FBpp0300338
## 139 7227.FBpp0073010 7227.FBpp0300338
## 140 7227.FBpp0076520 7227.FBpp0300338
## 141 7227.FBpp0079772 7227.FBpp0300338
## 142 7227.FBpp0085117 7227.FBpp0300338
## 143 7227.FBpp0085489 7227.FBpp0300338
## 144 7227.FBpp0085736 7227.FBpp0300338
## 145 7227.FBpp0271918 7227.FBpp0300338
## 146 7227.FBpp0070873 7227.FBpp0302814
## 147 7227.FBpp0075820 7227.FBpp0302814
## 148 7227.FBpp0071593 7227.FBpp0303832
## 149 7227.FBpp0073606 7227.FBpp0303832
## 150 7227.FBpp0073762 7227.FBpp0303832
## 151 7227.FBpp0081947 7227.FBpp0303832
## 152 7227.FBpp0082412 7227.FBpp0303832
## 153 7227.FBpp0070871 7227.FBpp0305828
## 154 7227.FBpp0071794 7227.FBpp0305828
## 155 7227.FBpp0072072 7227.FBpp0305828
## 156 7227.FBpp0073010 7227.FBpp0305828
## 157 7227.FBpp0073290 7227.FBpp0305828
## 158 7227.FBpp0079041 7227.FBpp0305828
## 159 7227.FBpp0079772 7227.FBpp0305828
## 160 7227.FBpp0081947 7227.FBpp0305828
## 161 7227.FBpp0085117 7227.FBpp0305828
## 162 7227.FBpp0085489 7227.FBpp0305828
## 163 7227.FBpp0085736 7227.FBpp0305828
## 164 7227.FBpp0086226 7227.FBpp0305828
## 165 7227.FBpp0100177 7227.FBpp0305828
## 166 7227.FBpp0300338 7227.FBpp0305828
## 167 7227.FBpp0073568 7227.FBpp0298344
## 168 7227.FBpp0081347 7227.FBpp0298344
output$Networks[[1]]
##                 from                to
## 1     6239.C03G5.1.2    6239.C05G5.4.1
## 2       6239.B0250.5  6239.C16A3.10a.1
## 3     6239.C06G3.11a      6239.C18E9.6
## 4       6239.C18E9.6    6239.C29E4.8.1
## 5     6239.C29E4.8.1    6239.C34B2.6.1
## 6       6239.B0250.5   6239.C34C12.8.1
## 7       6239.C18E9.6   6239.C34C12.8.1
## 8     6239.C29E4.8.1   6239.C34C12.8.1
## 9     6239.C34B2.6.1   6239.C34C12.8.1
## 10    6239.C03G5.1.2   6239.C34E10.6.2
## 11    6239.C05G5.4.1   6239.C34E10.6.2
## 12    6239.C29E4.8.1   6239.C34E10.6.2
## 13    6239.C06G3.11a    6239.C47G2.3.1
## 14      6239.C18E9.6    6239.C47G2.3.1
## 15   6239.C34C12.8.1    6239.C47G2.3.1
## 16    6239.C06G3.11a        6239.DY3.1
## 17      6239.C18E9.6        6239.DY3.1
## 18    6239.C47G2.3.1        6239.DY3.1
## 19    6239.C06G3.11a    6239.E04A4.5.2
## 20      6239.C18E9.6    6239.E04A4.5.2
## 21   6239.C34C12.8.1    6239.E04A4.5.2
## 22    6239.C47G2.3.1    6239.E04A4.5.2
## 23        6239.DY3.1    6239.E04A4.5.2
## 24   6239.C34E10.6.2    6239.E04A4.7.3
## 25  6239.C16A3.10a.1   6239.F10D11.1.2
## 26    6239.C34B2.6.1   6239.F10D11.1.2
## 27   6239.C34C12.8.1   6239.F10D11.1.2
## 28      6239.B0250.5  6239.F13D12.4a.2
## 29    6239.C03G5.1.2  6239.F13D12.4a.2
## 30   6239.C34E10.6.2  6239.F13D12.4a.2
## 31    6239.C29E4.8.1   6239.F29C12.4.2
## 32   6239.C34C12.8.1   6239.F29C12.4.2
## 33   6239.C34E10.6.2   6239.F29C12.4.2
## 34    6239.C03G5.1.2    6239.F42A8.2.1
## 35    6239.C05G5.4.1    6239.F42A8.2.1
## 36   6239.C34E10.6.2    6239.F42A8.2.1
## 37    6239.E04A4.7.3    6239.F42A8.2.1
## 38   6239.F10D11.1.2    6239.F42A8.2.1
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## 115   6239.T20G5.2.2  6239.Y37D8A.14.2
## 116 6239.C16A3.10a.1   6239.Y38F1A.6.6
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## 125   6239.T08B2.8.2 6239.Y66D12A.22.2
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## 127   6239.E04A4.7.3    6239.ZK1248.14
## 128  6239.K08F11.5.2    6239.ZK1248.14
## 129   6239.R05G6.7.2    6239.ZK1248.14
## 130   6239.C03G5.1.2     6239.ZK836.2a
## 131   6239.C05G5.4.1     6239.ZK836.2a
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## 133   6239.F42A8.2.1     6239.ZK836.2a
## 134   6239.F43G9.1.2     6239.ZK836.2a
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## 137   6239.T20G5.2.2     6239.ZK836.2a
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## 139  6239.F57B9.4b.1      6239.ZK652.9
## 140     6239.R07B7.5      6239.ZK652.9
## 141 6239.C16A3.10a.1   6239.ZK1128.1.2
output$maps
## [[1]]
##    UNIPROT_AC         STRING_id
## 1      Q9XTI0      6239.B0250.5
## 2      Q22347    6239.T08G2.3.1
## 3      Q9XXK1    6239.H28O16.1a
## 4      P46561   6239.C34E10.6.2
## 5      P50140 6239.Y22D7AL.5a.2
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## 13     Q09508    6239.C03G5.1.2
## 14     Q09545    6239.F42A8.2.1
## 15     Q23629     6239.ZK836.2a
## 16     Q27257    6239.F49E8.5.1
## 17     Q9XV52   6239.F29C12.4.2
## 18     Q9N3T2     6239.Y47G6A.8
## 19     Q23424    6239.ZK1248.14
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## 21     Q9U2M4   6239.Y38F1A.6.6
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## 36     Q09422    6239.R07G3.5.2
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## 41     Q9N5N8     6239.H06I04.2
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## 
## [[2]]
##    UNIPROT_AC        STRING_id
## 1      Q9V8M5 7227.FBpp0085821
## 2      Q9VSA3 7227.FBpp0076520
## 3      P35381 7227.FBpp0071794
## 4      Q05825 7227.FBpp0305828
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## 8      Q9VYF8 7227.FBpp0073568
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## 31     Q7JQW6 7227.FBpp0288705
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## 36     Q8IMX7 7227.FBpp0302814
## 37     Q7KW39 7227.FBpp0070087
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output$maps[[2]]
##    UNIPROT_AC        STRING_id
## 1      Q9V8M5 7227.FBpp0085821
## 2      Q9VSA3 7227.FBpp0076520
## 3      P35381 7227.FBpp0071794
## 4      Q05825 7227.FBpp0305828
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## 11     Q9VVG6 7227.FBpp0298344
## 12     Q9V6U9 7227.FBpp0086748
## 13     Q7KSC4 7227.FBpp0083137
## 14     Q9VFJ2 7227.FBpp0082412
## 15     Q9V784 7227.FBpp0086555
## 16     Q9W107 7227.FBpp0072334
## 17     Q9VTM5 7227.FBpp0291478
## 18     Q9VF08 7227.FBpp0082657
## 19     Q94523 7227.FBpp0085736
## 20     P21914 7227.FBpp0085489
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## 23     Q9VM33 7227.FBpp0079041
## 24     Q7K7A9 7227.FBpp0086223
## 25     Q7YU24 7227.FBpp0070873
## 26     P48604 7227.FBpp0086795
## 27     Q9W265 7227.FBpp0071759
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