Create a Solver class object using an ensemble of solvers

EnsembleSolver(mtx.assay = matrix(), targetGene, candidateRegulators,
  solverNames = c("lasso", "lassopv", "pearson", "randomForest", "ridge",
  "spearman", "xgboost"), geneCutoff = 0.1, alpha.lasso = 0.9,
  alpha.ridge = 0, lambda.lasso = numeric(0),
  lambda.ridge = numeric(0), lambda.sqrt = numeric(0),
  nCores.sqrt = 4, nOrderings.bayes = 10, quiet = TRUE)

Arguments

mtx.assay

An assay matrix of gene expression data

targetGene

A designated target gene that should be part of the mtx.assay data

candidateRegulators

The designated set of transcription factors that could be associated with the target gene

solverNames

A character vector of strings denoting

geneCutoff

A fraction (0-1) of the supplied candidate regulators to be included in the fetaures output by the solver (default = 0.1)

alpha.lasso

A fraction (0-1) denoting the LASSO-Ridge balance of the `glmnet` solver used by the LASSO method (default = 0.9)

alpha.ridge

A fraction (0-1) denoting the LASSO-Ridge balance of the `glmnet` solver used by the Ridge method (default = 0)

lambda.lasso

The penalty parameter for LASSO, used to determine how strictly to penalize the regression coefficients. If none is supplied, this will be determined via permutation testing (default = NULL).

lambda.ridge

The penalty parameter for Ridge, used to determine how strictly to penalize the regression coefficients. If none is supplied, this will be determined via permutation testing (default = NULL).

lambda.sqrt

The penalty parameter for square root LASSO, used to determine how strictly to penalize the regression coefficients. If none is supplied, this will be determined via permutation testing (default = NULL).

nCores.sqrt

An integer denoting the number of computational cores to devote to the square root LASSO solver, which is the slowest of the solvers (default = 4)

nOrderings.bayes

An integer denoting the number of random starts to use for the Bayes Spike method (default = 10)

quiet

A logical denoting whether or not the solver should print output

Value

A Solver class object with Ensemble as the solver

See also

Examples

load(system.file(package="trena", "extdata/ampAD.154genes.mef2cTFs.278samples.RData")) target.gene <- "MEF2C" tfs <- setdiff(rownames(mtx.sub), target.gene) ensemble.solver <- EnsembleSolver(mtx.sub, target.gene, tfs)