Supervised Normalization of Microarrays

Bioconductor version: 2.8

SNM is a modeling strategy especially designed for normalizing high-throughput genomic data. The underlying premise of our approach is that your data is a function of what we refer to as study-specific variables. These variables are either biological variables that represent the target of the statistical analysis, or adjustment variables that represent factors arising from the experimental or biological setting the data is drawn from. The SNM approach aims to simultaneously model all study-specific variables in order to more accurately characterize the biological or clinical variables of interest.

Author: Brig Mecham <brig.mecham at> and John D. Storey <jstorey at>

Maintainer: Brig Mecham <brig.mecham at>

To install this package, start R and enter:


To cite this package in a publication, start R and enter:



PDF R Script snm Tutorial
PDF   Reference Manual


biocViews Microarray, OneChannel, TwoChannel, MultiChannel, DifferentialExpression, ExonArray, GeneExpression, Transcription, MultipleComparisons, Preprocessing, QualityControl
Depends R(>= 2.12.0), lme4, splines, corpcor
System Requirements
License LGPL
Depends On Me
Imports Me
Suggests Me
Version 1.0.0
Since Bioconductor 2.8 (R-2.13)

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Package Source snm_1.0.0.tar.gz
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MacOS 10.5 (Leopard) binary snm_1.0.0.tgz
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Fred Hutchinson Cancer Research Center