A correction of the local pooled error (LPE) method to replace the asymptotic variance adjustment with an unbiased adjustment based on sample size.

Bioconductor version: 2.8

Two options are added to the LPE algorithm. The original LPE method sets all variances below the max variance in the ordered distribution of variances to the maximum variance. in LPEadj this option is turned off by default. The second option is to use a variance adjustment based on sample size rather than pi/2. By default the LPEadj uses the sample size based variance adjustment.

Author: Carl Murie <carl.murie at mcgill.ca>, Robert Nadon <robert.nadon at mcgill.ca>

Maintainer: Carl Murie <carl.murie at mcgill.ca>

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PDF R Script LPEadj test for microarray data with small number of replicates
PDF   Reference Manual


biocViews Microarray, Bioinformatics, Proteomics
Depends LPE
Imports LPE, stats
System Requirements
License LGPL
Depends On Me
Imports Me
Suggests Me
Version 1.12.0
Since Bioconductor 2.3 (R-2.8)

Package Downloads

Package Source LPEadj_1.12.0.tar.gz
Windows Binary LPEadj_1.12.0.zip (32- & 64-bit)
MacOS 10.5 (Leopard) binary LPEadj_1.12.0.tgz
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Fred Hutchinson Cancer Research Center