Changes in version 2.12.0: NEW FEATURES o Accelerated similarity searching of large small molecule data sets via new eiR add-on package NEW FEATURES o Jarvis-Patrick clustering of large small molecule data sets NEW FEATURES o SQLite support for small molecule management Changes in version 2.10.0: NEW FEATURES o Streaming functionality for SDFs enables processing of millions of molecules on a laptop NEW FEATURES o Fast and memory efficient fingerprint searches with atom pair fingerprints or PubChem fingerprints NEW FEATURES o Flexible maximum common substructure (MCS) search support provided by new fmcs.R add-on package