Significance Analysis of Function and Expression

Bioconductor version: Release (2.12)

SAFE is a resampling-based method for testing functional categories in gene expression experiments. SAFE can be applied to 2-sample and multi-class comparisons, or simple linear regressions. Other experimental designs can also be accommodated through user-defined functions.

Author: William T. Barry

Maintainer: William T. Barry <bbarry at>

To install this package, start R and enter:


To cite this package in a publication, start R and enter:



PDF R Script SAFE manual
PDF   Reference Manual


biocViews FunctionalAnnotation, GeneExpression, Software
Version 3.0.0
In Bioconductor since BioC 1.6 (R-1.11) or earlier
License GPL (>= 2)
Depends R (>= 2.4.0), AnnotationDbi, Biobase, methods, SparseM
Suggests GO.db, KEGG.db, PFAM.db, hgu133a.db, breastCancerUPP, survival, foreach, doRNG, Rgraphviz, GOstats
System Requirements
Depends On Me
Imports Me
Suggests Me

Package Downloads

Package Source safe_3.0.0.tar.gz
Windows Binary (32- & 64-bit)
Mac OS X 10.6 (Snow Leopard) safe_3.0.0.tgz
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