escalation 0.2.3

• Added three new vignettes on phase I/II designs, TITE-designs, and combination designs.
• Added BOIN-COMB MTD selector
• Added tests and docs
• Fixed bugs and typos

escalation 0.2.2

• Added boin12_rds() to tabulate desirability scores in a BOIN12 trial.

escalation 0.2.1

• Added unadmit_untested(), a selector to explicitly mark any untested and non-recomended dose as inadmissible via dose_admissible().

escalation 0.2.0

• Added support for treatment combinations by allowing dose to become a vector of indices rather than a scalar.
• Added BOIN COMB design for treatment combinations.

escalation 0.1.10

• Added TITE methods

escalation 0.1.9

• Fixed inheritance problems with as_tibble, summary and print dose_selector generics
• Added many tests of dose_selector consistency.

escalation 0.1.8

• Made tests faster for CRAN

escalation 0.1.7

• Added ability to import and export PatientSamples
• Split the simulation vignette

escalation 0.1.6

• Implement efficient simulation comparison method of Sweeting et al. in simulate_compare()
• Implement BOIN12 design
• Add MTD / OBD selectors for TPI, mTPI, mTPI2 and BOIN12 for final dose choice at end of a trial

escalation 0.1.5

• Add mTPI2 dose-finding method
• Fixed some bugs

escalation 0.1.4

• Added Neuenschwander, Branson & Sponer’s method for phase I.
• Added Ji et al.’s TPI & mTI methods for phase I.
• Added Thall & Cook’s EffTox method for phase I/II.
• Added Wages & Tait’s method for phase I/II.

escalation 0.1.3

• Mainly small changes to comply with dplyr v1.0.
• simulations and crystallised_dose_paths given summary method
• NOTE squash

escalation 0.1.2

• Methods for simulation and calculating dose-paths added.
• A bit more on the general selector interface.
• Everything new has tests, and more tests on old stuff.

escalation 0.1.1

• Initial release.
• dfcrm, BOIN, 3+3 models supported.
• several objects included to facilitate stopping at different events.
• class for a fixed escalation plan included, as sometimes used with CRM.