BBMBC: Beta-Binomial Models for Vaccine-Specific Memory B Cell
Frequency and Power Calculations
Provides tools to model overdispersed vaccine-specific memory B cell frequencies using
Beta-Binomial generalized linear models, specifically designed for
analyzing vaccine-induced cellular immune responses. Includes
method-of-moments dispersion estimation, likelihood ratio testing
across experimental arms, and Monte Carlo simulation frameworks to
calculate statistical power and Type I error rates. The methodologies
are directly motivated by the analysis of immunology data in
'Vaccination with mRNA-encoded membrane-anchored HIV envelope trimers
elicited tier 2 neutralizing antibodies in a phase 1 clinical trial'
(Parks et al. 2025) <doi:10.1126/scitranslmed.ady6831>.
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