Population Fisher Information Matrix R package PFIM version 8.0.1 CRAN Task View: Pharmacokinetics (https://CRAN.R-project.org/view=Pharmacokinetics) Evaluate or optimize designs for nonlinear mixed effects models using the Fisher Information matrix; see <doi:10.1093/biomet/84.2.429> and <doi:10.1016/S0169-2607(00)00117-6>. Supports population, individual, and Bayesian 'FIMs', covariates, inter-occasion variability, and D-optimal search ('Fedorov-Wynn', multiplicative, simplex, 'PSO', 'PGBO'). Software Depends: R (>= 4.5.0) Imports: utils, Deriv, Rcpp, methods, deSolve, purrr, stringr, S7 (>= 0.2.0), Matrix, ggplot2 (>= 3.5.0), kableExtra, tibble, scales, stats, rmarkdown, rlang, knitr, tools, grDevices LinkingTo: Rcpp, RcppArmadillo Suggests: testthat (>= 3.2.3), withr France Mentré <pfim@inserm.fr> Comprehensive R Archive Network (CRAN) Romain Leroux [aut] (ORCID: <https://orcid.org/0009-0009-5779-5303>), France Mentré [cre] (ORCID: <https://orcid.org/0000-0002-7045-1275>), Lucie Fayette [ctb] (ORCID: <https://orcid.org/0009-0001-0048-5998>), Antoine Croxo [ctb] (ORCID: <https://orcid.org/0009-0007-4726-5259>), Jérémy Seurat [ctb] (ORCID: <https://orcid.org/0000-0002-8127-7751>) GPL-3 2026-10-16 application/tgz https://CRAN.R-project.org/package=PFIM doi:10.32614/CRAN.package.PFIM