<?xml version="1.0" encoding="UTF-8"?>
<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title>Optimal Two-Stage Designs for Ordered Categorical Outcomes</dc:title>
  <dc:title>R package OptOTrials version 1.1.0</dc:title>
  <dc:description>Functions to design and simulate optimal two-stage randomized
    controlled trials (RCTs) with ordered categorical outcomes, using
    rank-based tests and interim decision rules for futility and superiority,
    following Park (2025) &lt;doi:10.1371/journal.pone.0318211&gt;. The functions
    'rule()', 'op()' and 'design_table()' provide a single entry point for
    constructing designs, evaluating their operating characteristics, and
    tabulating several designs at once. The separate functions provided for
    each combination of test statistic and stopping rule up to version 1.0.2
    were deprecated in 1.0.3 and are removed here. Please see the package
    reference manual and the vignette for details.</dc:description>
  <dc:type>Software</dc:type>
  <dc:relation>Depends: R (&gt;= 4.0)</dc:relation>
  <dc:relation>Imports: stats</dc:relation>
  <dc:relation>Suggests: knitr, rmarkdown, testthat (&gt;= 3.0.0)</dc:relation>
  <dc:creator>Yeonhee Park &lt;yeonheepark@skku.edu&gt;</dc:creator>
  <dc:publisher>Comprehensive R Archive Network (CRAN)</dc:publisher>
  <dc:contributor>Yeonhee Park [aut, cre],
  Yudi Wang [aut],
  Zhanpeng Xu [aut]</dc:contributor>
  <dc:rights>GPL-3</dc:rights>
  <dc:date>2026-09-23</dc:date>
  <dc:format>application/tgz</dc:format>
  <dc:identifier>https://CRAN.R-project.org/package=OptOTrials</dc:identifier>
  <dc:identifier>doi:10.32614/CRAN.package.OptOTrials</dc:identifier>
</oai_dc:dc>
